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Fig. 1. Deletion of mouse Wnt7b results in hypoplastic lungs.
(A) Strategy to remove Wnt7b from only the embryo proper.
(B) Mutant lungs are 50% smaller than wild-type at E18.5. The overall
mass of the embryo is unchanged. (C) Mutant lungs are 75% smaller than
wild-type at E14.5. The overall mass of the embryo is unchanged. (D)
Control and mutant lungs at E12.5. E-cadherin staining shows grossly normal
lobulation in mutant lungs. However, the right medial lobe bronchus
(*) of the Wnt7b mutant lung emanates from the cephalic
lobe bronchus.