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Figure 4


Fig. 4. Preserved expression of many factors affecting growth in Wnt7b mutant lungs. (A-E') E14.5 ISH of Wnt7b mutant (A'-E') and control (A-E) mouse lungs. Expression of Shh (A,A'), Gli1 (B,B'), Ptch1 (C,C') and Spry2 (E,E') are unchanged in the mutant. The epithelial tip is encircled. Fgf10 staining (D,D') is largely preserved in mutant lungs; there is a variable decrease in the most-distal expression of Fgf10 in mutant lungs (arrowhead). (F-G') E14.5 immunohistochemistry for N-myc (F,F') and fibronectin expression (G,G') showing that these are unchanged in the mutant. ISH signal (purple) is indicated by the arrowheads.





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