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Fig. 5. The bip2⁴ mutant genetically interacts with Antp^Ctx. (A) Head of an Antp^Ctx/+; ci^D/+ fly with an ectopic wing (W) on the dorsal head. The wing shows the characteristic wing margin bristles. (B) Head of an Antp^Ctx/+; bip2⁴/+ fly with the head capsule transformed into dorsal thorax (Th). One eye is missing and one eye is strongly reduced. Flies showing an ectopic wing on the dorsal head regularly show a normal or mildly reduced eye and no head capsule-to-thorax transformation. Flies with a head capsule-to-thorax transformation mostly show severely reduced or lost eyes. The eye reduction was therefore used as a measure of the two phenotypes shown above. (C) Analysis of eye-to-wing transformation and the strength of eye reduction in the progeny of Antp^Ctx females crossed to yw; bip2⁴/ci^D males. The number of F1 flies counted were: Antp^Ctx;+; ci^D/+, 233; Antp^Ctx/+; bip2⁴/+, 234. Only 4% of the flies with a single bip2 gene copy (Antp^Ctx;+; ci^D/+) show ectopic wings on their dorsal head, compared with 14% with two wild-type bip2 gene copies (Antp^Ctx/+; bip2⁺/bip2⁺; see Table 2). Normal (slightly reduced) sized eyes, reduced (strongly reduced) and missing eyes were counted. Flies with a single bip2 gene copy show a stronger eye reduction phenotype than do flies harbouring two gene copies.

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