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Figure 2


Fig. 2. Loss of expression of parvalbumin in Runx3-/- DRGs during development. (A-F) Photomicrographs indicate parvalbumin (PV) immunoreactivity (brown) at E14.5 (A,D), E18.5 (B,E) and P0 (C,F) in wild-type (A-C) and Runx3-/- (D-F) DRGs at the level of Th12. (G) Quantification of PV+ DRG neurons from E14.5 to P0. The number of PV+ neurons in wild-type (white squares) and Runx3-/- (black squares) mice are shown, and virtually no neurons express PV in Runx3-/- DRGs through these developmental stages. SC, spinal cord. Data are shown as mean±s.e.m.; *P<0.001. Scale bar: 100 µm.





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