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Fig. 3. Transient loss of TrkC expression in
Runx3-/- DRGs during
development. (A-J) Photomicrographs showing TrkC immunoreactivity
(brown) at E11.5 (A,F), E13.5 (B,G), E14.5 (C,H), E18.5 (D,I) and P0 (E,J) in
wild-type (A-E) and Runx3-/- (F-J) DRGs at the level of
Th10. (K) Quantification of TrkC+ DRG neurons from E13.5 to
P0. The number of TrkC+ DRG neurons was consistently smaller in
Runx3-/- (black circles) than in wild type (white circles)
mice between E13.5 and P0. (L-O) Immunoreactivity of TrkC in
Runx3+/+; Bax-/- (L,M) and in
Runx3-/-; Bax-/- (N,O) DRGs at the level of
Th10. The DRGs of L and N are shown at higher magnification in M and O,
respectively. TrkC was expressed in Runx3+/+;
Bax-/- DRG neurons but not in Runx3-/-;
Bax-/- DRG neurons. Data are shown as mean ±s.e.m.;
*P<0.05, **P<0.01,
***P<0.001. Scale bars: 100 µm in J and in N for
L,N; 50 µm in O for M,O.
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