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Fig. 2. Reduced body mass, altered body composition and skeletal defects of Ror2^{W749FLAG/W749FLAG} mutants. (A,B) Comparison of 5-month-old control (A) and Ror2^{W749FLAG/W749FLAG} littermate (B) mice; the mutants display a smaller body and a shorter, kinked tail. (C-F) Radiographic analysis of skeletons from wild-type (C) and Ror2^{W749FLAG/W749FLAG} (D-F) adult mice. Ror2^{W749FLAG/W749FLAG} animals display reduced length of the axial skeleton due to shorter vertebrae (D) and have a missing phalange in digits II-IV (inset, arrowheads). (E) Distal tail radiography from two mutant mice showing fused vertebrae (arrowhead) and hemivertebrae with misaligned articular surfaces, causing tail kinks (arrows). (F) Right hindlimb radiography from a Ror2^{W749FLAG/W749FLAG} mouse with preaxial polydactyly (arrow). Note a missing phalanx in all the other digits (arrowhead). (G) Weight curves of heterozygous (HET) and homozygous (KI) Ror2^W749FLAG male mice from a single litter, n=3-4. (H) Measurements of lean and fat mass in Ror2^{W749FLAG/W749FLAG} mice (KI) and litter-matched wild-type controls (WT). (I) Percentage fat mass (white stacked bar) and lean mass (dotted bar) in Ror2^{W749FLAG/W749FLAG} mice (KI) and controls (WT). Eight Ror2^{W749FLAG/W749FLAG} and five wild-type littermate male mice were evaluated at 21 weeks of age (H,I). Values are means±s.e.m. Significantly different from controls: ^**P<0.01; ^*P<0.05.

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