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Fig. 3. The craniofacial defects in Ror2^{W749FLAG/W749FLAG} mutants are due to changes in the nasal bones and orbital width. (A) Facial phenotype of Ror2^{W749FLAG/W749FLAG} mice (right), showing shorter snout, increased intercanthal distance and entropion eyes. (B-D) Comparison of crania from heterozyogous control (left) and homozygous mutant (right) Ror2^W749FLAG mice (9-month-old males), viewed from dorsal (B) and lateral (C,D) aspects. The double arrows indicate the craniometric linear measurements that showed significant differences: (1) nasal length, (2) intermaxillar width, (3) intraorbital width and (4) mandible anterior length. (E-H) Average lengths and widths (mm) of craniometric parameters that were significantly different between Ror2^{W749FLAG/W749FLAG} mice and control littermates. Values represent the mean±s.e.m. of triplicate measurements from five heterozyogous (HET) and five homozyogous (KI) mice. Significantly different from controls: ^**P<0.01; ^*P<0.05.

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