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Figure 4


Fig. 4. Transient decrease in trabecular bone volume in Ror2W749FLAG/W749FLAG mutants. (A,B) Representative femur sections from a 3-week-old Ror2W749FLAG/W749FLAG mouse (B) and a wild-type littermate (A), stained with Toluidine Blue. (C) Static and dynamic histomorphometric parameters in Ror2W749FLAG/W749FLAG male mice (white bars) and control littermates (black bars) at 3, 8 and 24 weeks. Parameters analyzed were: bone volume/tissue volume (BV/TV, %); trabecular number (Tr.N,/mm); trabecular separation (Tr.Sp, µm); number of osteoblasts/tissue area (N.Ob/T.Ar,/mm2); osteoblast surface/bone surface (Ob.S/BS, %); mineralizing surface/bone surface (MS/BS, %); mineral apposition rate (MAR, µm/day); bone formation rate/bone surface (BFR/BS, µm3/µm2/day). For static histomorphometry, sections were stained with Toluidine Blue. For dynamic histomorphometry, unstained sections were analyzed by fluorescence microscopy. Values are means±s.e.m. (n=6-11). Significantly different from controls: **P<0.01; *P<0.05.





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