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Figure 8


Fig. 8. Absence of Gdf5 expression in the distal phalangeal interzone of Ror2W749FLAG/W749FLAG mutants. Gdf5 expression was analyzed by in situ hybridization in limbs from wild-type (WT, A,C,E) and Ror2W749FLAG/W749FLAG (B,D,F) embryos. (A,B) Whole-mount in situ hybridization of forelimbs from E12.5 embryos, showing identical patterns of Gdf5 expression in the mutant. (C,D) Sections of E13.5 forelimbs, revealing reduced expression of Gdf5 in the proximal phalangeal interzone of Ror2W749FLAG/W749FLAG digits (D, 1/2). (E,F) Sections from E15.5 digits, showing normal Gdf5 expression levels in the proximal phalangeal interzone of the Ror2W749FLAG/W749FLAG digit (F, 1/2), but absence of signal in the presumptive distal interzone (2/3). MC, metacarpal; P1, phalanx 1; P2, phalanx 2.





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