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Fig. 2. Tbx18 expression indicates early compartmentalization of otic
mesenchyme. (A-R) Comparative analysis of Tbx18, Sox9 and
Pou3f4 expression during cochlea development by RNA in situ
hybridization on adjacent sagittal sections of wild-type heads. Probes and
developmental stages are as indicated in the figure. (A,D,G,J,M,P)
Tbx18 expression is confined to the inner zone of periotic mesenchyme
representing prospective otic fibrocytes during all developmental stages.
(B,E,H,K,N,Q) Mesenchymal Sox9 expression is found in regions of high
cell condensation, like the early periotic mesenchyme, the prospective otic
capsule, the condensing spiral limbus and the condensing mesenchyme underlying
the future stria vascularis. (C,F,I,L,O,R) Developmental expression of
Pou3f4 in the inner ear is initially pan-mesenchymal but becomes
restricted to prospective otic fibrocytes after E13.5. CD, cochlear duct; OE,
otic epithelium; OtC, otic capsule; PM, periotic mesenchyme; RM, Reissner's
membrane; SE, sensory epithelium; SG, spiral ganglion; SL, spiral ligament;
SLB, spiral limbus; SM, scala media; ST, scala tympani; StV, stria vascularis;
SV, scala vestibuli.
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