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Fig. 4. Histological and ultrastructural defects in the Tbx18KO
cochlea. Hematoxylin and Eosin staining (A-J) of midmodiolar
sections of the inner ear and ultastructural analysis of the stria vascularis
(K,L) of control and Tbx18KO mice at P21. Black
rectangles highlight regions of higher magnification. (A,B) Tbx18KO
cochleae are normal in shape but reduced in size. (C,D) Higher magnification
of the medial region reveals improper encapsulation of the ganglion by bone
tissue in Tbx18KO mice (white arrowheads). (E,F) Higher magnification
of the basal turn reveals hypoplasia of the lateral wall in Tbx18KO
mice. Arrow and arrowhead in F indicate the loss of suprastrial and type IV
fibrocytes, respectively. (G,H) Magnified view of the Organ of Corti does not
reveal any obvious phenotypic changes in Tbx18KO mice (I,J).
Magnification of the lateral wall shows stria vascularis malformations and
defects in otic fibrocytes in Tbx18KO mice. White arrow in J
indicates extension of the marginal cells into Reissner's membrane (RM). (K,L)
Ultrastructural analysis of the stria vascularis in the basal coil uncovers
the presence of large gaps between the cellular processes of strial cells. BC,
basal cells; IC, intermediate cells; MC, marginal cells; OC, Organ of Corti;
SP, spiral prominence; for further abbreviations, see
Fig. 2.
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