QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online April 11, 2008

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Dicty cell cycle comes into view

Several factors have conspired against the imaging of the Dictyostelium cell cycle, not least the lack of markers to distinguish its different phases. But on p. 1647, Muramoto and Chubb announce the creation of transgenic Dictyostelium that carry a live-cell fluorescent marker for the S phase. The role of the cell cycle during Dictyostelium development is controversial - whether differentiating cells replicate their DNA during development and the cell-cycle phase that the spores are in are matters of debate. Here, the authors report that after development is initiated, differentiating cells undergo a wave of DNA synthesis. Most spores, they reveal, are in G2, which begins after DNA synthesis and before mitosis starts. Furthermore, by inducing double-strand DNA breaks, they describe the first identified Dictyostelium checkpoint - at the G2-M transition. Since Dictyostelium has vertebrate DNA repair enzymes not present in yeast or invertebrates, these findings should illuminate future studies of the cell cycle's role in developmental processes in both Dictyostelium and other organisms.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Live imaging of the Dictyostelium cell cycle reveals widespread S phase during development, a G2 bias in spore differentiation and a premitotic checkpoint

Tetsuya Muramoto and Jonathan R. Chubb
Development 2008 135: 1647-1657. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?