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Fig. 5. The feedback model of X chromosome inactivation. (A) A
description of the components required for the model. (B,a) The active
X chromosomes produce a trans-acting signal, A, that saturates specific sites
on the autosomes. (b) Once saturated, the autosomes produce a swarm of
inactivation signals, I. These signals bind to each other and to XCI
inhibitors on the X chromosomes. Once all of the XCI inhibitors on an X
chromosome are sufficiently bound by I, the XCI initiator induces
inactivation. (c) With only one active X chromosome producing A, the
autosomes are no longer saturated with A and stop producing I.
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