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Fig. 6. Three different paths to X inactivation. (A) In a normal X
chromosome, all of the XCIrepress loci must be turned off
by I. (B) In a mutant X chromosome where some of the
XCIrepress loci have been removed, only a small amount of
I is required to initiate XCI. Because these chromosomes have a lower
threshold to overcome before initiating XCI, there is a higher probability
that they will inactivate. (C) In a mutant X chromosome where all of
the XCIrepress loci have been removed, XCI will initiate
without any I.