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Fig. 6. Wnt7b signals to the adjacent interstitium through the
canonical Wnt signaling pathway. (A) Hematoxylin and Eosin staining
of E18.5 kidney sections following the removal of β-catenin activity from
the renal interstitial mesenchyme. Mutant kidneys lack a renal medulla. Scale
bar: 400 µm. (B) In situ hybridization (Axin2) and
immunostaining (Lef1) on sections of E15.5 kidneys. A marked reduction was
observed in Axin2 mRNA and Lef1 protein expression within the
interstitial mesenchyme positioned adjacent to the nascent medullary
collecting ducts (arrows) following removal of β-catenin activity from
this cell population. By contrast, their expression was not altered in other
renal tissues. Cyto, cytokeratin. Scale bars: 200 µm in top four panels;
100 µm in all other panels.
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