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Figure 7


Fig. 7. p57Kip2 expression in mesenchyme cells of the medullary interstitium is dependent on a Wnt7b canonical signaling pathway. (A-T) The distribution of p57Kip2 was compared in E15.5 kidney sections from wild-type (A-E,K-O), Wnt7b mutants (F-J) and mutants lacking β-catenin within the interstitial mesenchyme (P-T). p57Kip2 protein was present in a subset of medullary interstitium within wild-type kidneys (nuclear staining in C,M). The interstitial expression of p57Kip2 was lost in this population in Wnt7b mutants (H), but was retained in podocytes (asterisk in H). By contrast, Hoxa11 was present throughout the renal interstitium of wild-type (B) and Wnt7b mutant (G) kidneys. When p57Kip2 was examined in interstitial cells of β-catenin interstitium mutants (β-galactosidase-positive from genetic labeling), p57Kip2 was not expressed in interstitial mesenchyme (R), except in rare cases where cells had escaped recombination (β-galactosidase-negative cells in insets in Q-S). Scale bar: 40 µm.





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