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Figure 4


Fig. 4. FGF signaling is required for membrane localization of the PCP pathway proteins Dsh and PKC-{delta} in Xenopus dorsal mesoderm. Dsh-GFP and PKC-{delta}-YFP proteins are membrane-localized in wild-type Xenopus dorsal marginal zone (DMZ) (A-B') and cytoplasmically localized in the animal cap (AC) (E-F'). Treatment with the FGFR inhibitor SU5402 between stages 10.5 and 12 causes Dsh and PKC-{delta} to delocalize from the membrane in DMZ (C-D'); compare with DMSO-treated controls (A-B'). All embryos are co-injected with membrane RFP (mRFP, red) to label the cell membrane.





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