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First published online December 7, 2008

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Novel neuronal migration mode branches out

Many migrating neurons and growing axons reach their correct targets during brain development by adjusting the growth of their leading process in response to guidance cues. Now, though, Martini and co-workers propose that the dynamic regulation of leading process branching may represent a novel guidance mechanism for migrating neurons (see p. 41). The researchers use time-lapse videomicroscopy to analyse the dynamic behaviour of individual neurons migrating tangentially in mouse telencephalic slices. Cortical interneurons (and other populations of GABAergic neurons) consistently form branched processes during their migration, they report, and respond to chemoattractant signals by generating branches that are better aligned with the source of the signal rather than by re-orientating existing branches. In addition, guidance cues influence the angle at which new branches emerge, and inhibition of branching with a ROCK inhibitor (Rho/ROCK signalling regulates the actin cytoskeleton) blocks chemotaxis. Thus, the researchers suggest, the directional migration of neurons that have branched leading processes may be achieved by stabilising the most suitable branch.

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Biased selection of leading process branches mediates chemotaxis during tangential neuronal migration

Francisco J. Martini, Manuel Valiente, Guillermina López Bendito, Gábor Szabó, Fernando Moya, Miguel Valdeolmillos, and Oscar Marín
Development 2009 136: 41-50. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?