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First published online April 24, 2009

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PANning for AG

In flowers, the conserved transcription factor AGAMOUS (AG) is important for reproductive organ development and for terminating stem cell maintenance, but how is its own activation controlled? Now, on p. 1613, Jan Lohmann and co-workers reveal that the bZIP transcription factor PERIANTHIA (PAN) directly regulates AG in Arabidopsis. The researchers show that PAN binds to a highly conserved AG enhancer motif and is required for in vivo AG enhancer activity. AG expression levels usually do not change in pan mutants, indicating that other factors redundantly regulate AG expression, but they decrease when pan mutants are grown in shorter days, demonstrating that the regulatory circuitry of AG senses environmental influences. Conversely, in ag mutants, PAN expression continues for too long, suggesting that a negative-feedback loop exists between the two factors. A second study by Das, Meyerowitz and colleagues corroborates the role of PAN in regulating AG (see p. 1605). Based on their findings, the authors of both studies propose that PAN directly regulates AG expression as part of a redundant regulatory network.

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Related articles in Development:

Floral stem cell termination involves the direct regulation of AGAMOUS by PERIANTHIA

Pradeep Das, Toshiro Ito, Frank Wellmer, Teva Vernoux, Annick Dedieu, Jan Traas, and Elliot M. Meyerowitz
Development 2009 136: 1605-1611. [Abstract] [Full Text]  

Dual roles of the bZIP transcription factor PERIANTHIA in the control of floral architecture and homeotic gene expression

Annette T. Maier, Sandra Stehling-Sun, Heike Wollmann, Monika Demar, Ray L. Hong, Silke Haubeiß, Detlef Weigel, and Jan U. Lohmann
Development 2009 136: 1613-1620. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?