QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online April 24, 2009

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Sonic hedgehog enhanced from a distance

Sonic hedgehog (Shh) signalling is a key player in vertebrate development, patterning structures ranging from the nervous system to the limb. It is also crucial for the morphogenesis of the epithelial lining of the mouth and of the respiratory and gut tubes in mice. Here, on p. 1665, Toshihiko Shiroishi and co-workers identify long-range enhancers that regulate regional Shh expression in the epithelial lining and demonstrate their developmental function. By comparing genomic sequences across mammals and teleost fish, the authors identify three conserved non-coding sequences (CNCSs) upstream of the Shh coding region, which together recapitulate Shh expression in the epithelial lining of the oral cavity, pharynx, lung and gut. To examine the function of CNCSs in vivo, the researchers deleted the one that drives pharyngeal Shh expression and report that this results in the severe underdevelopment of pharyngeal structures, such as the soft palate. These results indicate that the three long-range Shh enhancers partition the epithelial lining into three domains and are required for proper epithelial morphogenesis.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

A cluster of three long-range enhancers directs regional Shh expression in the epithelial linings

Tomoko Sagai, Takanori Amano, Masaru Tamura, Yoichi Mizushina, Kenta Sumiyama, and Toshihiko Shiroishi
Development 2009 136: 1665-1674. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?