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Figure 4


Fig. 4. The effect of loss of Notch receptors on surface accumulation of DeltaD. (A-C') A comparison of DeltaD distribution in wild type, notch1a and notch3 morphants, and mibm178 mutant zebrafish embryos at the tail bud stage. Areas shown here approximately correspond to rectangular areas in Fig. S1A-D (see supplementary material). Embryos are double-stained with zdD2 (grey in A-C, green in A'-C') and β-catenin (red in A'-C'). DeltaD-expressing cells are increased and DeltaD is mainly localized at cell surface in both Notch morphants (B,B') and mibm178 mutants (C,C'). (D-F') DeltaD distribution in Notch morphants with (F,F') or without (E,E') co-injection of deltaA and deltaD (deltaA&D) MOs. Though co-injection of deltaA&D MO dramatically reduces zdD2 staining (compare E with F), DeltaD is still localized at the cell surface.





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