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First published online December 22, 2008

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Delta endocytosis: Mind bomb minds Notch

Notch signalling is essential for many aspects of development, including the mechanism of lateral inhibition, where cells that adopt a particular fate prevent adjacent cells from doing likewise. The endocytosis of the Notch ligand Delta is important for lateral inhibition and is regulated in zebrafish by the ubiquitin ligase Mind bomb 1 (Mib1). Now, Matsuda and Chitnis reveal that the endocytosis of certain zebrafish Delta homologues, such as DeltaD, crucially depends on their interaction with Notch itself and leads to their subsequent degradation (see p. 197). The authors report that DeltaD, which normally predominantly localises to the cytoplasm, instead localises to the plasma membrane in mib1 mutants and notch morphants. This is because DeltaD endocytosis depends on Notch-DeltaD interactions, regardless of whether Notch is expressed in the same (in cis) or in adjacent cells (in trans). Interactions in cis, however, are probably inhibitory, whereas interactions in trans activate Notch signalling in the adjacent cells, suggesting a mechanism whereby this process might contribute to lateral inhibition.

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Related articles in Development:

Interaction with Notch determines endocytosis of specific Delta ligands in zebrafish neural tissue

Miho Matsuda and Ajay B. Chitnis
Development 2009 136: 197-206. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?