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First published online December 22, 2008

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Armadillo positively stabilised by Hip(k)s

The conserved Wnt/wingless (Wg) signalling pathway controls many essential developmental processes. Consequently, it must be tightly regulated to ensure that development proceeds smoothly. On p. 241, Lee and colleagues reveal for the first time that homeodomain-interacting protein kinases (Hipks) positively regulate Wnt/Wg signalling. They report that the expression of hipk in developing Drosophila wings rescues the effects of Wg signal loss, while its overexpression in Drosophila cells promotes Wg signalling by stabilizing Armadillo, the Drosophila β-catenin homolog, which interacts with the transcription factor Tcf to promote target gene expression (in vertebrate cells, β-catenin interacts with Lef1 to achieve the same outcome). Furthermore, in Wg transcriptional assays, Hipk enhances Tcf/Armadillo-mediated gene expression in a kinase-dependent manner. Finally, the researchers show that, in vertebrate cells, Hipk2 promotes both β-catenin stabilization and Lef1/β-catenin-mediated gene expression. Together, these results suggest that the Hipks have a conserved role in promoting Wnt signalling that, somewhat surprisingly, involves Hipks acting in both the cytosol and the nucleus.

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Related articles in Development:

Homeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling through stabilization of β-catenin/Arm and stimulation of target gene expression

Wendy Lee, Sharan Swarup, Joanna Chen, Tohru Ishitani, and Esther M. Verheyen
Development 2009 136: 241-251. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?