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First published online December 22, 2008

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A fly's tup-thumping heart

The transcription factor (TF) Islet1 (Isl1) is important for the development of a cardiac cell lineage in mouse called the second heart field, which contributes to certain heart structures. However, the precise role of Isl1 in the early regulatory network that specifies cardiac progenitors from mesoderm remains unresolved. Now, Petra Pandur and co-workers report that tailup (tup), the Drosophila homolog of Isl1, is required for early cardiogenesis in flies (see p. 317). They show that Tup protein is expressed during cardiogenesis, and that tup is required for cardiac progenitor specification. In tup mutants, the expression of three conserved TFs (tinman/Nkx2.5, pannier/Gata4 and Dorsocross/Tbx5/6) that are part of the early cardiac regulatory network is downregulated. Conversely, Tup expression depends on each of these TFs. All four TFs interact genetically, and tup functions in both the ectoderm and mesoderm to regulate heart development. From their findings, the authors propose that tup is a crucial component of the early cardiac specification network, a role that might be conserved in vertebrates.

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Related articles in Development:

The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis

Tabea Mann, Rolf Bodmer, and Petra Pandur
Development 2009 136: 317-326. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?