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As reflected in this Minifocus, studies of the complex transforming growth factor β (TGFβ) signalling pathway are yielding new insights into this pathway's functions and regulation in development and disease at a rapid pace. This pace of progress is reflected in Kristi Wharton and Rik Derynck's review of a recent FASEB meeting on TGFβ signalling. For an appraisal of our current understanding of how Tgfβ signal transduction is regulated, see the review by Aristides Moustakas and Carl‑Henrik Heldin. David Umulis and colleagues discuss the molecules and processes that regulate the pathway extracellularly, often in a context-specific manner. Finally, Pascal Kahlem and Stuart Newfeld illustrate how phylogenetics and mathematical modeling can reveal the molecular mechanisms that underlie Tgfβ pathway regulation and activity.
The extracellular regulation of Bone Morphogenetic Protein signaling
by David Umulis, Michael B. O'Connor and Seth S. Blair (2009)
Development 2009 136: 3715-3728.
by Aristidis Moustakas and Carl‑Henrik Heldin (2009)
Development 2009 136: 3699-3714.
by Pascal Kahlem and Stuart J. Newfeld (2009)
Development 2009 136: 3729-3740.
TGFβ family signaling: novel insights in development and disease
by Kristi Wharton and Rik Derynck (2009)
Development 2009 136: 3691-3697.
Tao, S. et al
The Integrator subunits function in hematopoiesis by modulating Smad/BMP signaling
Development 2009 136: 2757-2765.
Rab5-mediated endocytosis of activin is not required for gene activation or long-range signalling in Xenopus
Development 2009 136: 2803-2813.
Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue
Development 2009 136:2187-2197.
Freeman-Anderson, N. E. et al
Expression of the Arf tumor suppressor gene is controlled by Tgfβ2 during development
Development 2009 136:2081-2089.
Jaramillo, M. S. et al
Crossveinless and the TGFβ pathway regulate fiber number in the Drosophila adult jump muscle
Development 2009 136: 1105-1113.
Roussigné, M. et al
Nodal signalling imposes left-right asymmetry upon neurogenesis in the habenular nuclei
Development 2009 136: 1549-1557.
Vallier, L. et al
Activin/Nodal signalling maintains pluripotency by controlling Nanog expression
Development 2009 136: 1339-1349.
Ng, J
TGFβ signals regulate axonal development through distinct Smad-independent mechanisms
Development 2008 135: 4025-4035.
Batut, J. et al
Two highly related regulatory subunits of PP2A exert opposite effects on TGF-β/Activin/Nodal signalling
Development 2008 135: 2927-2937.
Tian, J. et al
The pro-domain of the zebrafish Nodal-related protein Cyclops regulates its signaling activities
Development 2008 135: 2649-2658.
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