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Figure 5


Fig. 5. Oligodendrocytes from mice lacking netrin 1 or Dcc exhibit defects in process branching and in myelin-like membrane sheet formation. (A) Representative examples of the morphology of oligodendrocytes derived from wild-type and netrin-1-deficient or Dcc-deficient mice. 40x0.75 n.a. objective. Scale bar: 20 µm. (B) Application of netrin 1 increased branching by oligodendrocytes from Dcc+/+ and Dcc+/-, but not from Dcc-/-, mice. (C) Oligodendrocytes from Dcc-/- or Ntn1-/- mice exhibit no difference in branching complexity compared with cells from wild-type and heterozygous littermates. (D) Ntn1-/- oligodendrocytes exhibit a significant decrease in myelin-like membrane sheet area compared with cells derived from wild-type and heterozygote littermates. (E) Dcc-/- oligodendrocytes elaborate smaller myelin-like membrane sheets than wild-type and heterozygous littermates. A.U., arbitrary units. ***P<0.0001 versus control. Error bars indicate s.e.m.





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