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Figure 1


Fig. 1. Disrupted GC signaling in mature osteoblasts leads to delayed cranial bone formation. (A-F) Micro-CT images of the calvaria of wild-type and Col2.3-11βHSD2 transgenic mice. All images are of the same magnification, showing growth retardation in transgenic mice relative to wild-type animals. Scale bar: 1 mm. (A) Neonatal wild type (P1). (B) Neonatal Col2.3-11βHSD2 transgenic mouse (littermate of A). (C) Three-day-old wild type (P3). (D) Col2.3-11βHSD2 transgenic mouse (littermate of C). (E) Seven-day-old wild type (P7). (F) Col2.3-11βHSD2 transgenic mouse (littermate of E). (G-L) Embryonic skeletal preparations at E16.5. (G) Wild type. (H) Col2.3-11βHSD2 transgenic (littermate of G). (I) Enlarged head region of G. (K) Enlarged head region of H. (J) Enlarged head region of G, dorsal view. (L) Enlarged head region of H, dorsal view. Cartilage was stained using Alcian Blue and bone was stained using Alizarin Red. Areas of reduced bone formation are indicated by arrows.





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