spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 7


Fig. 7. The role of endogenous glucocorticoids in cranial bone development. Proposed model of relevant molecular mechanisms and signaling pathways. Glucocorticoids (GC) stimulate differentiated osteoblasts to produce Wnt proteins, which activate the Wnt/β-catenin signaling cascade in: (A) cranial mesenchymal progenitor cells, promoting osteoblastogenesis and inhibiting chondrogenesis through up-regulation of Runx2 and downregulation of Sox9 expression; (B) cranial osteoblasts, through upregulation of Mmp14 to initiate the remodeling of the collagenous matrix surrounding the osteoblast; and (C) cranial chondrocytes, through up-regulation of Mmp14 to initiate the cranial cartilage degradation.





Right arrow Return to article