DEV029769 Supplementary Material

Files in this Data Supplement:

• Supplemental Table S1 -

  Table S1. Set of promoters enriched by ChIP for both Pitx3 and Nurr1 in MN9D cells. ChIP-on-chip for Pitx3 and Nurr1 in MN9D cells identified 365 promoters that are enriched by both Pitx3 and Nurr1 false discovery rate (FDR)<0.01. Promoters that are enriched by both Pitx3 and Nurr1 in E14.5 mdDA neurons as well are indicated by an asterisk (*). The relative distance of the significant peak is indicated as a positive number (downstream TSS) or negative number (5′ upstream of transcription start site (TSS).

• Supplemental Table S2 -

  Table S2. Set of promoters enriched by ChIP for both Pitx3 and Nurr1 in E14.5 ventral midbrain derived mdDA neurons. ChIP-on-chip for Pitx3 and Nurr1 in vivo identified 58 promoters that are enriched by both Pitx3 and Nurr1 false discovery rate (FDR)<0.01. Promoters that are enriched by both Pitx3 and Nurr1 in MN9D cells as well are indicated by an asterisk (*). The relative distance of the significant peak is indicated as a positive number (downstream TSS) or negative number (5′ upstream of transcription start site (TSS).

• Supplemental Figure S1 -

  Fig. S1. Nurr1 interacts with HDAC1 in vivo. Lysates of E14.5 mdDA neurons were subjected to IP for Nurr1 or pre-immune serum and immunoblotted for Nurr1 and HDAC1. I, input; IP, immunoprecipitation; Ctrl, pre-immune serum control.