Supplemental Figure S1
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Fig. S1. Control of the efficiency of various drug treatments in cultured mouse embryos. Whole-mount in situ hybridization of lacZ (A-D) and sprouty 2 (E,F) mRNAs on wild-type embryos harboring the RARE-lacZ reporter transgene (A-D) or non-transgenic wild-type embryos (E,F) collected at E8.0 and incubated for 6 hours (A,B) or 3 hours (C-F) in the presence of 0.1% DMSO (A,E), 0.001% ethanol (C), 50 µM BMS493 (a synthetic pan-RAR antagonist) (B), 200 nM all-trans RA (D) or 50 µM SU5402 (F).
