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First published online February 6, 2009

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No REST in ES cell determination

The transcriptional repressor REST has been proposed to target transcription factors crucial for neuronal lineage specification or to maintain pluripotency in embryonic stem (ES) cells, but its specific role in ES cell determination remains unclear. On p. 715, Helle Jørgensen, Amanda Fisher and colleagues report that in ES cells, REST is not required for the repression of transcription factors crucial for neural lineage commitment or for maintaining ES cell potential. By analysing REST-depleted ES cells, the researchers demonstrate that neural determinants, such as MASH1 and neurogenin 1 and 2, remain appropriately repressed, and that the multi-lineage potential and dominant reprogramming capacity of ES cells do not depend on REST. However, a group of genes that is highly enriched for the REST-binding motif RE1, which is implicated in the terminal differentiation and function of neurons, is inappropriately expressed in REST-depleted cells, suggesting that REST might serve to regulate neuronal differentiation programmes rather than the initial stages of neuronal lineage commitment.

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Related articles in Development:

REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells

Helle F. Jørgensen, Anna Terry, Chiara Beretta, C. Filipe Pereira, Marion Leleu, Zhou-Feng Chen, Claire Kelly, Matthias Merkenschlager, and Amanda G. Fisher
Development 2009 136: 715-721. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?