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First published online February 6, 2009

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Neural crest does the two-step

Neural crest (NC) cells arise at the dorsal neural tube and give rise to a wide variety of cell types, including parts of the head and the peripheral nervous system. Although NC induction has been proposed to be a multi-step process, and the signals involved in this induction, including Wnt and BMP, have been identified, the spatiotemporal relationships between these factors have remained unclear. Now, on p. 771, Roberto Mayor and colleagues propose a novel two-step model for NC induction. By fate-mapping this tissue in gastrulating Xenopus embryos, the authors show that first, signals from a region of the prospective mesoderm, the dorsolateral marginal zone (DLMZ), induce the NC during gastrulation. In a second step, signals from the intermediate mesoderm, which derives from the DLMZ, maintain NC identity during neurulation. The authors further demonstrate that the first step requires Wnt activation and BMP inhibition, whereas the second requires the activation of both pathways, thus resolving long-standing controversies regarding the roles of these two pathways in NC induction.

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Related articles in Development:

Differential requirements of BMP and Wnt signalling during gastrulation and neurulation define two steps in neural crest induction

Ben Steventon, Claudio Araya, Claudia Linker, Sei Kuriyama, and Roberto Mayor
Development 2009 136: 771-779. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?