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First published online February 6, 2009

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Where integrins, growth factors and Wnts meet

Integrin-growth factor receptor interactions often serve to integrate the local signals from the extracellular matrix (ECM) with those provided by growth factors. Now, on p. 843, Jordan Kreidberg and co-workers show that such an interaction regulates Wnt expression in kidney morphogenesis. The authors report that in mice carrying mutations in either the integrin 3β1 subunit or in laminin, its main ECM ligand, the formation of the papilla, a collection of densely packed epithelial tubules in the kidney, is disrupted, and Wnt7b and Wnt4 expression is downregulated. Moreover, they demonstrate that signalling through c-Met - the receptor for Hgf, a growth factor involved in kidney morphogenesis - depends on 3β1 integrin and that an anti-Hgf antibody also downregulates Wnt7b levels. Finally, they show that Wnt signalling promotes cell survival in the papilla, allowing epithelial tubule elongation and papilla maturation. From their findings, they propose that coordinated integrin-c-Met signalling regulates Wnt expression during kidney development, highlighting the complexity of the input that controls morphogenetic events.

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Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis

Yingjie Liu, Nibedita Chattopadhyay, Shan Qin, Charles Szekeres, Tetyana Vasylyeva, Zhen X. Mahoney, Mary Taglienti, Carlton M. Bates, Harold A. Chapman, Jeffrey H. Miner, and Jordan A. Kreidberg
Development 2009 136: 843-853. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?