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First published online March 6, 2009

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Mouths open with Wnt antagonists

The primary mouth - the initial opening connecting the embryonic foregut to the outside world - forms from a mesoderm-free domain at the front of deuterostome embryos (in which the mouth forms after the anus). Early in the mouth's formation, the basement membrane between the ectoderm and endoderm in this domain disappears. Dickinson and Sive now report that Wnt antagonists locally regulate this process in Xenopus embryos (see p.1071). The researchers show that frzb-1 and crescent - which encode secreted frizzled-related proteins (sFRPs), a class of Wnt antagonists - are transiently and locally expressed in the primary mouth anlage. Other experiments indicate that sFRP function is crucial for primary mouth formation and that Frzb-1 overexpression decreases the expression of the basement membrane genes fibronectin and laminin, whereas Wnt-8 overexpression increases their expression. These data, which are the first to connect Wnt signalling and basement membrane integrity during primary mouth development, suggest that the modulation of Wnt signalling might regulate basement membrane remodelling during other developmental processes.

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Related articles in Development:

The Wnt antagonists Frzb-1 and Crescent locally regulate basement membrane dissolution in the developing primary mouth

Amanda J. G. Dickinson and Hazel L. Sive
Development 2009 136: 1071-1081. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?