QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online March 6, 2009

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Planar cell polarity signals for bone growth

During long-bone growth, proliferative chondrocytes in the growth plate cartilage form clonal columns of discoid cells, which enlarge to form the hypertrophic chondrocytes that make bone. But what regulates column formation, and is this columnar organisation crucial for bone morphogenesis? On p.1083, Li and Dudley investigate these questions and, for the first time, implicate a planar cell polarity (PCP)-like pathway in the regulation of bone morphogenesis. They show that the plane of cell division in proliferative chondrocytes in chick long bones is orthogonal to the direction of growth and that the resultant daughter cells, which are initially displaced laterally, intercalate to form a single column of cells. Both the division plane and orientation of the chondrocytes depend on β-catenin-independent, noncanonical Wnt/frizzled signalling, and the disruption of this signalling pathway produces abnormally short and thick long bones. Thus, by regulating the cell polarity of growth plate chondrocytes, noncanonical frizzled signalling (probably via a PCP-like pathway) plays a crucial role in bone morphogenesis.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Noncanonical frizzled signaling regulates cell polarity of growth plate chondrocytes

Yuwei Li and Andrew T. Dudley
Development 2009 136: 1083-1092. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?