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First published online March 6, 2009

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CARMIL Racs down neuronal migrations

Many molecules that promote neuronal and axonal growth cone migrations during neuronal development have been identified. Now, however, Vanderzalm and colleagues report that CRML-1 (the C. elegans homologue of the mammalian actin-uncapping protein CARMIL) negatively regulates these important migrations in C. elegans by inhibiting Rac signalling (see p. 1201). Signalling through Rac GTPases is known to be involved in axonal migration because mutations in Rac GTPases and in their guanine nucleotide exchange factors (GEFs) disrupt axonal migration in Drosophila and C. elegans. The researchers identify CRML-1 as a negative regulator of neuron and axon migrations in a C. elegans genetic screen. They then show that CRML-1 inhibits the Rac GEF activity of UNC-73 (a homologue of the mammalian Rac and Rho GEF Trio) and that CRML-1 lowers the levels of the neuronal guidance receptor SAX-3; UNC-73 increases the levels of this Robo homologue. Together, these results reveal a novel role for a CARMIL homologue - the negative regulation of neuron and axon migrations through the inhibition of Rac signalling.

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Related articles in Development:

C. elegans CARMIL negatively regulates UNC-73/Trio function during neuronal development

Pamela J. Vanderzalm, Amita Pandey, Michael E. Hurwitz, Laird Bloom, H. Robert Horvitz, and Gian Garriga
Development 2009 136: 1201-1210. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?