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First published online April 10, 2009

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Insulin signals for control of germline stem cell divisions

The cell cycle of stem cells is tightly controlled so that they can divide throughout life and respond to challenges such as injury and starvation. Defects in this control could result in abnormal tissue maintenance or cancer. Now, Hannele Ruohola-Baker and co-workers analyse cell division in Drosophila germline stem cells (GSCs) and reveal that the cell cycle regulator Dacapo is suppressed by microRNAs (miRNAs); in turn, the miRNAs might be controlled by insulin (p. 1497). This group has previously shown that the miRNA pathway regulates Dacapo in GSCs. Here, the authors demonstrate that several miRNAs can target the dacapo 3' UTR directly, and that mutations in these miRNAs lead to abnormal GSC divisions. The dacapo 3' UTR also responds to insulin receptor (InR), but not to TGF-β, signalling (two pathways known to regulate GCS divisions), and InR-deficient GSCs display defects resembling those of miRNA pathway mutants. Based on these and other findings, the authors propose that insulin regulates the division of GSCs through miRNAs and Dacapo.

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Related articles in Development:

Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells

Jenn-Yah Yu, Steven H. Reynolds, Steve D. Hatfield, Halyna R. Shcherbata, Karin A. Fischer, Ellen J. Ward, Dang Long, Ye Ding, and Hannele Ruohola-Baker
Development 2009 136: 1497-1507. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?