Desmin sequence elements regulating skeletal muscle-specific expression in transgenic mice

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Babai, F., Musevi-Aghdam, J., Schurch, W., Royal, A. and Gabbiani, G (1990). Coexpression of-sarcomeric actin, -smooth muscle actin and desmin during myogenesis in rat and mouse embryos I. Skeletal muscle. Differentiation 44, 132-142.[Medline]

Baldwin, T. J. and Burden, S. J (1989). Muscle-specific gene expression controlled by a regulatory element lacking a MyoD1-binding site. Nature 341, 716-720.[Medline]

Bober, E., Lyons, G. E., Braun, T., Cossu, G., Buckingham, M. and Arnold, H. H (1991). The muscle regulatory gene, myf-6 has a biphasic pattern of expression during early mouse development. J. Cell Biol 133, 1255-1265.

Brennan, T. J. and Olson, E. N (1990). Myogenin resides in the nucleus958and acquires high affinity for a conserved enhancer element on heterodimerization. Genes Dev 4, 582-595.[Abstract/Free Full Text]

Brinster, R. L., Chen, H. Y., Trumbauer, M. E., Yagle, M. K. and Palmiter, R. D (1985). Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc. Natl. Acad. Sci. USA 82, 4438-4442.[Abstract/Free Full Text]

Buskin, J. N. and Hauschka, S. D (1989). Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene. Mol. Cell. Biol 9, 2627-2640.[Abstract/Free Full Text]

Caravatti, M., Minty, A., Robert, B., Montarras, D., Weydert, A., Cohen, A., Daubas, P. and Buckingham, M (1982). Regulation of muscle gene expression. The accumulation of messenger RNAs coding for muscle-specific proteins during myogenesis in a mouse cell line. J. Mol. Biol 160, 59-76.[Medline]

Chevallier, A., Kieny, M. and Mauger, A (1977). Limb-somite relationship: origin of the limb musculature. J. Embryol. Exp. Morph 41, 245-258.[Medline]

Christ, B., Jacob, H. J. and Jacob, M (1977). Experimental analysis of the origin of the wing musculature in avian embryos. Anat. Embryol 150, 171-186.[Medline]

Couly, G. F., Coltey, P. M. and Le Douarin, N. M (1992). The developmental fate of the cephalic mesoderm in quail-chick chimeras. Development 114, 1-15.[Abstract]

Cusella-De-Anjelis, M. G., Lyons, G., Sonnino, C., De Angelis, L., Vivarelli, E., Farmer, K., Wright, W. E., Molinaro, M., Bouche, M., Buckingham, M. and Cossu, G (1992). MyoD, myogenin independent differenciation of primordial myoblasts in mouse somites. J. Cell. Biol 116, 1243-1255.[Abstract/Free Full Text]

Dingwall, C. and Laskey, R. A (1986). Protein import into the cell nucleus. Ann. Rev. Cell. Biol 2, 367-390.

Donoghue, M., Ernst, H., Wentworth, B., Nadal-Ginard, B. and Rosenthal, N (1988). A muscle-specific enhancer is located at the 3end of the myosin light-chain 1/3 gene locus. Genes Dev 2, 1779-1790.[Abstract/Free Full Text]

Furst, D. O., Osborn, M. and Weber, K (1989). Myogenesis in the mouse embryo: differential onset of expression of myogenic proteins and the involvement of titin in myofibril assembly. J. Cell. Biol 109, 517-527.[Abstract/Free Full Text]

Geisler, N. and Weber, K (1982). The amino acid sequence of chiken muscle desmin provides a common structural model for intermediate filament proteins. EMBO J 1, 1649-1656.[Medline]

Gorza, L., Sartore, S., Thornell, L. E. and Schiaffino, S (1986). Myosin type and fiber types in cardiac muscle. III. Nodal conduction tissue. J. Cell Biol 102, 1758-1766.[Abstract/Free Full Text]

Gorza, L., Schiaffino, S. and Vitadello, M (1987). Heart conduction system: a neural crest derivative?. Brain Res 457, 360-366.

Gossett, L. A., Kelvin, D. J., Sternberg, E. A. and Olson, E. N (1989). A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes. Mol. Cell. Biol 9, 5022-5033.[Abstract/Free Full Text]

Gunning, P., Hardeman, E., Wade, R., Ponte, P., Bains, W., Blau, H. M. and Kedes, L (1987). Differential patterns of transcript accumulation during human myogenesis. Mol. Cell. Biol 7, 4100-4114.[Abstract/Free Full Text]

Hannon, K., Smith II, C. K., Bales, K. R. and Santerre, R. F (1992). Temporal quantitative analysis of myogenic regulatory and growth factor gene expression in the developing mouse embryo. Dev. Biol 151, 137-144.[Medline]

Hill, C. S., Duran, S., Lin, Z., Weber, K. and Holtzer, H (1986). Titin and myosin, but not desmin, are linked during myofibrillogenesis in postmitotic mononucleated myoblasts. J. Cell. Biol 103, 2185-2196.[Abstract/Free Full Text]

Horlick, R. A. and Benfield, P. A (1989). The upstream muscle-specific enhancer of the rat muscle creatine kinase gene is composed of multiple elements. Mol. Cell. Biol 9, 2396-2413.[Abstract/Free Full Text]

Jacob, M., Christ, B. and Jacob, H. J (1979). The migration of myogenic cells from the somites into the leg region of avian embryos. Anat. Embryol 157, 291-309.[Medline]

Jaynes, J. B., Johnson, J. E., Buskin, J. N., Gartside, C. L. and Hauschka, S. D (1988). The muscle creatine kinase gene is regulated by multiple upstream elements, including a muscle-specific enhancer. Mol. Cell. Biol 8, 62-70.[Abstract/Free Full Text]

Johnson, J. E., Wold, B. J. and Hauschka, S. D (1989). Muscle creatine kinase sequence elements regulating skeletal and cardiac muscle expression in transgenic mice. Mol. Cell. Biol 9, 3393-3399.[Abstract/Free Full Text]

Jostes, B., Walther, C. and Gruss, P (1991). The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system. Mech. Dev 33, 27-38.

Kalderon, D., Roberts, B. L., William.D. R. and Smith, A. E (1984). A short amino acid sequence able to specify nuclear location. Cell 39, 499-509.[Medline]

Kaufman, S. J. and Foster, R. F (1988). Replicating myoblasts express a muscle-specific phenotype. Proc. Natl. Acad. Sci. USA 85, 9606-9610.[Abstract/Free Full Text]

Klasfeld, A., Bessereau, J. L., Salmon, A. M., Triller, A., Babinet, C. and Changeux, J. P (1991). An acetylcholine receptor-subunit promoter confering preferential synaptic expression in muscle of transgenic mice. EMBO J 10, 625-632.[Medline]

Kozak, M (1987). An analysis of 5-noncoding sequences from 699 vertebrate messenger RNAs. Nucl. Acids Res 15, 8125-8131.[Abstract/Free Full Text]

Lassar, A. B., Buskin, J. N., Lockshon, D., Davis, L., Apone, S., Hauschka, D. and Weintraub, H (1989). MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer. Cell 58, 823-831.[Medline]

Le Douarin, N. M (1984). Cell migrations in embryos. Cell 38, 353-360.[Medline]

Lee, K. J., Ross, R. S., Rockman, H. A., Harris, A., O'Brien, T., Van Bilsen, M., Shubeita, H. E., Kandolf, R., Brem, G., Price, J., Evans, S. M., Zhu, H., Franz, W. M. and Chien, K. R (1992). Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene. J. Biol. Chem 267, 15875-15885.[Abstract/Free Full Text]

Lennon, V. A., Peterson, S. and Shubert, D (1979). Neurectoderm markers retained in phenotypical skeletal muscle cells arising from a glial cell line. Nature 281, 586-588.[Medline]

Li, Z., Lilienbaum, A., Butler-Browne, G. and Paulin, D (1989). Human desmin coding gene : complete nucleotide sequence, characterization and regulation of expression during myogenesis and development. Gene 78, 243-254.[Medline]

Li, Z. and Paulin, D (1991). High level desmin expression depends on a muscle-specific enhancer. J. Biol. Chem 266, 6562-6570.[Abstract/Free Full Text]

Mayo, M., Brinbas, M., Santos, V., Shum, L. and Slavkin, H. C (1992). Desmin expression during early mouse tongue morphogenesis. J. Dev. Biol 36, 255-263.

Ordahl, C. P. and Le Douarin, M (1992). Two myogenic lineages within the developing somite. Development 114, 339-353.[Abstract]

Phillips, M. T., Kirby, M. L. and Forbes, G (1987). Analysis of cranial neural crest distribution in the developing heart using quail-chick chimeras,. Circ. Res 60, 27-30.[Abstract/Free Full Text]

Pieper, F. R., Slobbe, R. L., Ramaekers, F. C. S., Cuypers, H. T. and Bloemendal, H (1987). Upstream regions of the hamster desmin and vimentin genes regulate expression during in vitro myogenesis. EMBO J 6, 3611-3618.[Medline]

Quax, W., Broek, L. V. D., Egberts, W. V., Ramaekers, F. and Bloemendal, H (1985). Characterization of the hamster desmin gene: expression and formation of desmin filaments in nonmuscle cells after gene transfer. Cell 43, 327-338.[Medline]

Rosenthal, N., Kornhauser, J. M., Donoghue, M., Rosen, K. M. and Merlie, J. P (1989). Myosin light chain enhancer activates muscle-specific, developmentally regulated gene expression in transgenic mice. Proc. Natl. Acad. Sci.USA 86, 7780-7784.[Abstract/Free Full Text]

Sanes, J. R., Rubinstein, J. L. and Nicolas, J. F (1986). Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos. EMBO. J 5, 3133-3142.[Medline]

Sanes, J., Johnson, Y., Kotzbauer, P., Mudd, J., Hanley, T., Martinou, J. C. and Merlie, J (1991). Selective expression of an acetylcholine receptor-lacZ transgene in synaptic nuclei of adult muscle fibers. Development 113, 1181-1191.[Abstract]

Sassoon, D., Lyons, G., Wright, W. E., Lin, V., Lassar, A., Weintraub, H. and Buckingham, M (1989). Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis. Nature 341, 303-307.[Medline]

Schaart, G., Viebahn, C., Langmann, W. and Ramaekers, F (1989). Desmin and titin expression in early postimplantation mouse embryos. Development 107, 585-596.[Abstract]

Small, J. V. and Sobieszek, A (1977). Studies on the function and composition of the 10-nm (100-A) filaments of vertebrate smooth muscle. J. Cell Sci 23, 243-268.[Abstract/Free Full Text]

Sternberg, E., Spizz, G., Perry, W. M., Vizard, D., Weil, T. and Olson, E. N (1988). Identification of upstream and intragenic regulatory elements that confer cell-type-restricted and differentiation-specific expression on the muscle creatine kinase gene. Mol. Cell. Biol 8, 2896-2909.[Abstract/Free Full Text]

Tam, P. P. L. and Beddington, R. S (1987). The formation of mesodermal tissues in the mouse embryo during gastrulation and early organogenesis. Development 99, 109-126.[Abstract]

Thornell, L. E. and Eriksson, A (1981). Filament system in the Purkinje fibers of the heart. Am. J. Physiol 241, 291-305.

Viragh, Sz. and Challice, C. E (1977). The development of the conduction system in the mouse embryo heart. Dev. Biol 56, 397-411.[Medline]

Wang, Y., H.P., X., Wang, X. M., Ballivet, M. and Schmidt, J (1988). A cell type-specific enhancer drives expression of the chick muscle acetylcholine receptor-subunit gene. Neuron 1, 527-534.[Medline]

Wang, X. M., Tsay, H. J. and Schmidt, J (1990). Expression of the acetylcholine receptor-subunit gene in differentiating chick muscle cells is activated by an element that contains two 16 bp copies of a segment of the -subunit enhancer. EMBOJ 9, 783-790.[Medline]

Wilkinson, D. G., Bhatt, S., Chavrier, P., Bravo, R. and Charnay, P (1989). Segment-specific expression of a Zinc-finger gene in the developing nervous system of the mouse. Nature 337, 461-463.[Medline]

Yutzey, K. E., Kline, R. L. and Konieczny, S. F (1989). An internal regulatory element controls troponin I gene expression. Mol. Cell. Biol 9, 1397-1405.[Abstract/Free Full Text]

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				Y. Torrente, G. Camirand, F. Pisati, M. Belicchi, B. Rossi, F. Colombo, M. El Fahime, N. J. Caron, A. C. Issekutz, G. Constantin, et al. Identification of a putative pathway for the muscle homing of stem cells in a muscular dystrophy model J. Cell Biol., August 4, 2003; 162(3): 511 - 520. [Abstract] [Full Text] [PDF]

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				A. M. Munoz-Marmol, G. Strasser, M. Isamat, P. A. Coulombe, Y. Yang, X. Roca, E. Vela, J. L. Mate, J. Coll, M. T. Fernandez-Figueras, et al. A dysfunctional desmin mutation in a patient with severe generalized myopathy PNAS, September 15, 1998; 95(19): 11312 - 11317. [Abstract] [Full Text] [PDF]

				A. F.M. Moorman, F. de Jong, M. M.F.J. Denyn, and W. H. Lamers Development of the Cardiac Conduction System Circ. Res., April 6, 1998; 82(6): 629 - 644. [Full Text] [PDF]

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				J. Gao, Z. Li, and D. Paulin A Novel Site, Mt, in the Human Desmin Enhancer Is Necessary for Maximal Expression in Skeletal Muscle J. Biol. Chem., March 13, 1998; 273(11): 6402 - 6409. [Abstract] [Full Text] [PDF]

				Z. Li, M. Mericskay, O. Agbulut, G. Butler-Browne, L. Carlsson, L.-E. Thornell, C. Babinet, and D. Paulin Desmin Is Essential for the Tensile Strength and Integrity of Myofibrils but Not for Myogenic Commitment, Differentiation, and Fusion of Skeletal Muscle J. Cell Biol., October 6, 1997; 139(1): 129 - 144. [Abstract] [Full Text] [PDF]

				T. Alyonycheva, L. Cohen-Gould, C. Siewert, D. A. Fischman, and T. Mikawa Skeletal Muscle�Specific Myosin Binding Protein-H Is Expressed in Purkinje Fibers of the Cardiac Conduction System Circ. Res., May 19, 1997; 80(5): 665 - 672. [Abstract] [Full Text]

				S. Schiaffino Protean Patterns of Gene Expression in the Heart Conduction System Circ. Res., May 19, 1997; 80(5): 749 - 750. [Full Text]

				K. Takahashi and P. A. Coulombe Defining a Region of the Human Keratin 6a Gene That Confers Inducible Expression in Stratified Epithelia of Transgenic Mice J. Biol. Chem., May 2, 1997; 272(18): 11979 - 11985. [Abstract] [Full Text] [PDF]

				J Fontaine-Perus, P Halgand, Y Cheraud, T Rouaud, M. Velasco, C Cifuentes Diaz, and F Rieger Mouse-chick chimera: a developmental model of murine neurogenic cells Development, January 8, 1997; 124(16): 3025 - 3036. [Abstract] [PDF]

				K. Takahashi and P.�A. Coulombe A transgenic mouse model with an inducible skin blistering disease�phenotype PNAS, December 10, 1996; 93(25): 14776 - 14781. [Abstract] [Full Text] [PDF]

				J Fontaine-Perus, V Jarno, C Fournier le Ray, Z Li, and D Paulin Mouse chick chimera: a new model to study the in ovo developmental potentialities of mammalian somites Development, January 6, 1995; 121(6): 1705 - 1718. [Abstract] [PDF]