flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Yamaguchi, T. P.
	Articles by Rossant, J.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Yamaguchi, T. P.
	Articles by Rossant, J.

Aprelikova, O., Pajusola, K., Partanen, J., Armstrong, E., Alitalo, R., Bailey, S. K., McMahon, J., Wasmuth, J., Huebner, K. and Alitalo, K (1992). FLT4 , a novel class III receptor tyrosine kinase in chromosome 5q33-qter. Cancer Research 52, 746-748.[Abstract/Free Full Text]

Breier, G., Albrecht, U., Sterrer, S. and Risau, W (1992). Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 114, 521-532.[Abstract]

Burkert, U., von Ruden, T. and Wagner, E. F (1991). Early fetal hematopoietic development from in vitro differentiated embryonic stem cells. New Biol 3, 698-708.[Medline]

Chomczynski, P. and Sacchi, N (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem 162, 156-159.[Medline]

Coffin, J. D. and Poole, T. J (1988). Embryonic vascular development: immunohistochemical identification of the origin and subsequent morphogenesis of the major vessel primordia in quail embryos. Development 102, 735-748.[Abstract/Free Full Text]

Coffin, J. D. and Poole, T. J (1991). Endothelial cell origin and migration in embryonic heart and cranial blood vessel development. Anat. Rec 231, 383-395.[Medline]

Conlon, R. A. and Rossant, J (1992). Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo. Development 116, 357-368.[Medline]

Conn, G., Bayne, M. L., Soderman, D., Kwok, P. W., Sullivan, K. A., Palisi, T. M., Hope, D. A. and Thomas, K. A (1990). Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor. Proc. Natl. Acad. Sci. USA 87, 2628-2632.[Abstract/Free Full Text]

De Vries, C., Escobedo, J. A., Ueno, H., Houck, K., Ferrara, N. and Williams, L. T (1992). The fms -like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255, 989-991.[Abstract/Free Full Text]

Doetschman, T., Eistetter, H., Katz, M., Schmidt, W. and Kemler, R (1985). The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands, and myocardium. J. Embryol. Exp. Morph 87, 27-45.[Medline]

Dumont, D. J., Yamaguchi, T. P., Conlon, R. A., Rossant, J. and Breitman, M. L (1992). tek , a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. Oncogene 7, 1471-1480.[Medline]

Emoto, N., Gonzalez, A.-M., Walicke, P. A., Wada, E., Simmons, D. M., Shimasaki, S. and Baird, A (1989). Basic fibroblast growth factor (FGF) in the central nervous system: Identification of specific loci of basic FGF expression in the rat brain. Growth Factors 2, 21-29.[Medline]

Folkman, J. and Klagsbrun, M (1987). Angiogenic factors. Science 235, 442-447.[Abstract/Free Full Text]

Forrester, L. M., Bernstein, A., Rossant, J. and Nagy, A (1991). Long-term reconstitution of the mouse hematopoietic system by embryonic stem cell-derived fetal liver. Proc. Natl. Acad. Sci. USA 88, 7514-7517.[Abstract/Free Full Text]

Galland, F., Karamysheva, A., Mattei, M.-G., Rosnet, O., Marchetto, S. and Birnbaum, D (1992). Chromosomal localization of FLT4 , a novel receptor-type tyrosine kinase gene. Genomics 13, 475-478.[Medline]

Hanks, S. K., Quinn, A. M. and Hunter, T (1988). The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241, 42-52.[Abstract/Free Full Text]

Holmgren, L., Glaser, A., Pfeifer-Ohlsson, S. and Ohlsson, R (1991). Angiogenesis during human extraembryonic development involves the spatiotemporal control of PDGF ligand and receptor gene expression. Development 113, 749-754.[Abstract]

Keck, P. J., Hauser, S. D., Krivi, G., Sanzo, K., Warren, T., Feder, J. and Connolly, D. T (1989). Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246, 1309-1312.[Abstract/Free Full Text]

Klagsbrun, M (1989). The fibroblast growth factor family: Structural and biological properties. Progress in Growth Factor Research 1, 207-235.[Medline]

Klagsbrun, M. and D'Amore, P. A (1991). Regulators of angiogenesis. Ann. Rev. Physiol 53, 217-239.[Medline]

Lai, C. and Lemke, G (1991). An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. Neuron 6, 691-704.[Medline]

Leung, D. W., Cachianes, G., Kuang, W.-J., Goeddel, D. V. and Ferrara, N (1989). Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246, 1306-1309.[Abstract/Free Full Text]

Matthews, W., Jordan, C. T., Gavin, M., Jenkins, N. A., Copeland, N. G. and Lemischka, I. R (1991). A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proc. Natl. Acad. Sci. USA 88, 9026-9030.[Abstract/Free Full Text]

Muslin, A. J. and Williams, L. T (1991). Well-defined growth factors promote cardiac development in axolotl mesodermal explants. Development 112, 1095-1101.[Abstract]

Nagy, A., Gocza, E., Merentes Diaz, E., Prideaux, V. P., Ivanyi, E., Markkula, M. and Rossant, J (1990). Embryonic stem cells alone are able to support fetal development in the mouse. Development 110, 815-821.[Abstract/Free Full Text]

Noden, D. M (1989). Embryonic origins and assembly of blood vessels. Am. Rev. Respir. Dis 140, 1097-1103.[Medline]

Noden, D. M (1990). Origins and assembly of avian embryonic blood vessels. Ann. N.Y. Acad. Sci 558, 236-249.

Orr-Urtreger, A., Givol, D., Yayon, A., Yarden, Y. and Lonai, P (1991). Developmental expression of two murine fibroblast growth factor receptors, flg and bek. Development 113, 1419-1434.[Abstract]

Pardanaud, L., Yassine, F. and Dieterlen-Lievre, F (1989). Relationship between vasculogenesis, angiogenesis and haemopoiesis during avian ontogeny. Development 105, 473-485.[Abstract/Free Full Text]

Partanen, J., Armstrong, E., Makela, T. P., Korhonen, J., Sandberg, M., Renkonen, R., Knuutila, S., Huebner, K. and Alitalo, K (1992). A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. Mol. Cell. Biol 12, 1698-1707.[Abstract/Free Full Text]

Partanen, J., Makela, T. P., Alitalo, R., Lehvaslaiho, H. and Alitalo, K (1990). Putative tyrosine kinases expressed in K-562 human leukemia cells. Proc. Natl. Acad. Sci. USA 87, 8913-8917.[Abstract/Free Full Text]

Peters, K. G., Werner, S., Chen, G. and Williams, L. T (1992). Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse. Development 114, 233-243.[Abstract]

Risau, W., Sariola, H., Zerwes, H.-G., Sasse, J., Ekblom, P., Kemler, R. and Doetschman, T (1988). Vasculogenesis and angiogenesis in embryonic stem-cell-derived embryoid bodies. Development 102, 471-478.[Abstract]

Sater, A. K. and Jacobson, A. G (1990). The role of the dorsal lip in the induction of heart mesoderm in Xenopus laevis. Development 108, 461-470.[Abstract]

Schmitt, R. M., Bruyns, E. and Snodgrass, H. R (1991). Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression. Genes Dev 5, 728-740.[Abstract/Free Full Text]

Schnurch, H. and Risau, W (1991). Differentiating and adult neurons express the acidic fibroblast growth factor gene during chick neural development. Development 111, 1143-1154.[Abstract/Free Full Text]

Shibuya, M., Yamaguchi, S., Yamane, A., Ikeda, T., Tojo, A., Matsushime, H. and Sato, M (1990). Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene ( flt ) closely related to the fms family. Oncogene 5, 519-524.[Medline]

Stark, K. L., McMahon, J. A. and McMahon, A. P (1991). FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse. Development 113, 641-651.[Abstract]

Stewart, P. A. and Wiley, M. J (1981). Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: a study using quail-chick transplantation chimeras. Dev. Biol 84, 183-192.[Medline]

Tam, P. P. L. and Beddington, R. S. P (1992). Establishment and organization of germ layers in the gastrulating mouse embryo. In Postimplantation Development in the Mouse. Ciba Foundation Symposium 165, 27-41.[Medline]

Terman, B. I., Carrion, M. E., Kovacs, E., Rasmussen, B. A., Eddy, R. L. and Shows, T. B (1991). Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 6, 1677-1683.[Medline]

Tischer, E., Gospodarowicz, D., Mitchell, R., Silva, M., Schilling, J., Lau, K., Crisp, T., Fiddes, J. C. and Abraham, J. A (1989). Vascular endothelial growth factor: a new member of the platelet-derived growth factor gene family. Biochem. Biophys. Res. Comm 165, 1198-1206.[Medline]

Wanaka, A., Milbrandt, J. and Johnson, E. M., Jr (1991). Expression of FGF receptor gene in rat development. Development 111, 455-468.[Abstract]

Wang, R., Clark, R. and Bautch, V. L (1992). Embryonic stem cell-derived cystic embryoid bodies form vascular channels: an in vitro model of blood vessel development. Development 114, 303-316.[Abstract]

Wiles, M. V. and Keller, G (1991). Multiple hematopoietic lineages develop from embryonic stem (ES) cells in culture. Development 111, 259-267.[Abstract]

Wilks, A. F (1989). Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction. Proc. Natl. Acad. Sci. USA 86, 1603-1607.[Abstract/Free Full Text]

Wilks, A. F., Harpur, A. G., Kurban, R. R., Ralph, S. J., Zurcher, G. and Ziemiecki, A (1991). Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol. Cell. Biol 11, 2057-2065.[Abstract/Free Full Text]

Williams, R. L., Hilton, D. J., Pease, S., Wilson, T. A., Stewart, C. L., Gearing, D. P., Wagner, E. F., Metcalf, D., Nicola, N. A. and Gough, N. M (1988). Myeloid leukemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 336, 684-687.[Medline]

Wilt, F. H (1965). Erythropoiesis in the chick embryo: the role of endoderm. Science 147, 1588-1590.[Abstract/Free Full Text]

Yamaguchi, T. P., Conlon, R. A. and Rossant, J (1992). Expression of the fibroblast growth factor receptor FGFR-1/flg during gastrulation and segmentation in the mouse embryo. Dev. Biol 152, 75-88.[Medline]

This article has been cited by other articles:

K. Ahlbrecht, J. Schmitz, U. Seay, C. Schwarz, R. Mittnacht-Kraus, A. Gaumann, R. V. Haberberger, S. Herold, G. Breier, F. Grimminger, et al.
Spatiotemporal Expression of flk-1 in Pulmonary Epithelial Cells during Lung Development
Am. J. Respir. Cell Mol. Biol., August 1, 2008; 39(2): 163 - 170.
[Abstract] [Full Text] [PDF]

G. Narazaki, H. Uosaki, M. Teranishi, K. Okita, B. Kim, S. Matsuoka, S. Yamanaka, and J. K. Yamashita
Directed and Systematic Differentiation of Cardiovascular Cells From Mouse Induced Pluripotent Stem Cells
Circulation, July 29, 2008; 118(5): 498 - 506.
[Abstract] [Full Text] [PDF]

T. J. Nelson, R. S. Faustino, A. Chiriac, R. Crespo-Diaz, A. Behfar, and A. Terzic
CXCR4+/FLK-1+ Biomarkers Select a Cardiopoietic Lineage from Embryonic Stem Cells
Stem Cells, June 1, 2008; 26(6): 1464 - 1473.
[Abstract] [Full Text] [PDF]

K. Yanagi, M. Takano, G. Narazaki, H. Uosaki, T. Hoshino, T. Ishii, T. Misaki, and J. K. Yamashita
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels and T-Type Calcium Channels Confer Automaticity of Embryonic Stem Cell-Derived Cardiomyocytes
Stem Cells, November 1, 2007; 25(11): 2712 - 2719.
[Abstract] [Full Text] [PDF]

M. M. Bakre, A. Hoi, J. C. Y. Mong, Y. Y. Koh, K. Y. Wong, and L. W. Stanton
Generation of Multipotential Mesendodermal Progenitors from Mouse Embryonic Stem Cells via Sustained Wnt Pathway Activation
J. Biol. Chem., October 26, 2007; 282(43): 31703 - 31712.
[Abstract] [Full Text] [PDF]

R. C. R. Perlingeiro
Endoglin is required for hemangioblast and early hematopoietic development
Development, August 15, 2007; 134(16): 3041 - 3048.
[Abstract] [Full Text] [PDF]

M. Kennedy, S. L. D'Souza, M. Lynch-Kattman, S. Schwantz, and G. Keller
Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures
Blood, April 1, 2007; 109(7): 2679 - 2687.
[Abstract] [Full Text] [PDF]

P. McGannon, Y. Miyazaki, P. C. Gupta, E. I. Traboulsi, and C. Colmenares
Ocular Abnormalities in Mice Lacking the Ski Proto-oncogene.
Invest. Ophthalmol. Vis. Sci., October 1, 2006; 47(10): 4231 - 4237.
[Abstract] [Full Text] [PDF]

A. Ishimura, J. K. Ng, M. Taira, S. G. Young, and S.-I. Osada
Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor {beta} signaling
Development, October 1, 2006; 133(19): 3919 - 3928.
[Abstract] [Full Text] [PDF]

Y. Chen, I. Amende, T. G. Hampton, Y. Yang, Q. Ke, J.-Y. Min, Y.-F. Xiao, and J. P. Morgan
Vascular endothelial growth factor promotes cardiomyocyte differentiation of embryonic stem cells
Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1653 - H1658.
[Abstract] [Full Text] [PDF]

C. Park, K. Lavine, Y. Mishina, C.-X. Deng, D. M. Ornitz, and K. Choi
Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation
Development, September 1, 2006; 133(17): 3473 - 3484.
[Abstract] [Full Text] [PDF]

M. Abe and Y. Sato
Puromycin insensitive leucyl-specific aminopeptidase (PILSAP) is required for the development of vascular as well as hematopoietic system in embryoid bodies.
Genes Cells, July 1, 2006; 11(7): 719 - 729.
[Abstract] [Full Text] [PDF]

D. Mehta and A. B. Malik
Signaling Mechanisms Regulating Endothelial Permeability
Physiol Rev, January 1, 2006; 86(1): 279 - 367.
[Abstract] [Full Text] [PDF]

M. Ema, S. Takahashi, and J. Rossant
Deletion of the selection cassette, but not cis-acting elements, in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors
Blood, January 1, 2006; 107(1): 111 - 117.
[Abstract] [Full Text] [PDF]

S. Taoudi, A. M. Morrison, H. Inoue, R. Gribi, J. Ure, and A. Medvinsky
Progressive divergence of definitive haematopoietic stem cells from the endothelial compartment does not depend on contact with the foetal liver
Development, September 15, 2005; 132(18): 4179 - 4191.
[Abstract] [Full Text] [PDF]

K. Hamada, T. Sasaki, P. A. Koni, M. Natsui, H. Kishimoto, J. Sasaki, N. Yajima, Y. Horie, G. Hasegawa, M. Naito, et al.
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
Genes & Dev., September 1, 2005; 19(17): 2054 - 2065.
[Abstract] [Full Text] [PDF]

L. Campagnolo, A. Leahy, S. Chitnis, S. Koschnick, M. J. Fitch, J. T. Fallon, D. Loskutoff, M. B. Taubman, and H. Stuhlmann
EGFL7 Is a Chemoattractant for Endothelial Cells and Is Up-Regulated in Angiogenesis and Arterial Injury
Am. J. Pathol., July 1, 2005; 167(1): 275 - 284.
[Abstract] [Full Text] [PDF]

G. Keller
Embryonic stem cell differentiation: emergence of a new era in biology and medicine
Genes & Dev., May 15, 2005; 19(10): 1129 - 1155.
[Abstract] [Full Text] [PDF]

S. L. D'Souza, A. G. Elefanty, and G. Keller
SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development
Blood, May 15, 2005; 105(10): 3862 - 3870.
[Abstract] [Full Text] [PDF]

L.-J. Duan, Y. Zhang-Benoit, and G.-H. Fong
Endothelium-Intrinsic Requirement for Hif-2{alpha} During Vascular Development
Circulation, May 3, 2005; 111(17): 2227 - 2232.
[Abstract] [Full Text] [PDF]

M. Iida, T. Heike, M. Yoshimoto, S. Baba, H. Doi, and T. Nakahata
Identification of cardiac stem cells with FLK1, CD31, and VE-cadherin expression during embryonic stem cell differentiation
FASEB J, March 1, 2005; 19(3): 371 - 378.
[Abstract] [Full Text] [PDF]

M. Eguchi, M. Eguchi-Ishimae, A. Green, T. Enver, and M. Greaves
Directing oncogenic fusion genes into stem cells via an SCL enhancer
PNAS, January 25, 2005; 102(4): 1133 - 1138.
[Abstract] [Full Text] [PDF]

H. T. Ku, N. Zhang, A. Kubo, R. O'Connor, M. Mao, G. Keller, and J. S. Bromberg
Committing Embryonic Stem Cells to Early Endocrine Pancreas In Vitro
Stem Cells, December 1, 2004; 22(7): 1205 - 1217.
[Abstract] [Full Text] [PDF]

I. NILSSON, C. ROLNY, Y. WU, B. PYTOWSKI, D. HICKLIN, K. ALITALO, L. CLAESSON-WELSH, and S. WENNSTROM
Vascular endothelial growth factor receptor-3 in hypoxia-induced vascular development
FASEB J, October 1, 2004; 18(13): 1507 - 1515.
[Abstract] [Full Text] [PDF]

E.A.V. Jones, M.H. Baron, S.E. Fraser, and M.E. Dickinson
Measuring hemodynamic changes during mammalian development
Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1561 - H1569.
[Abstract] [Full Text] [PDF]

A. Zippo, A. De Robertis, M. Bardelli, F. Galvagni, and S. Oliviero
Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro
Blood, June 15, 2004; 103(12): 4536 - 4544.
[Abstract] [Full Text] [PDF]

T. Chan-Ling, D. S. McLeod, S. Hughes, L. Baxter, Y. Chu, T. Hasegawa, and G. A. Lutty
Astrocyte-Endothelial Cell Relationships during Human Retinal Vascular Development
Invest. Ophthalmol. Vis. Sci., June 1, 2004; 45(6): 2020 - 2032.
[Abstract] [Full Text] [PDF]

C. Park, I. Afrikanova, Y. S. Chung, W. J. Zhang, E. Arentson, G. h. Fong, A. Rosendahl, and K. Choi
A hierarchical order of factors in the generation of FLK1- and SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells
Development, June 1, 2004; 131(11): 2749 - 2762.
[Abstract] [Full Text] [PDF]

Y. Sassa, Y. Hata, L. P. Aiello, Y. Taniguchi, K. Kohno, and T. Ishibashi
Bifunctional Properties of Peroxisome Proliferator-Activated Receptor {gamma}1 in KDR Gene Regulation Mediated via Interaction With Both Sp1 and Sp3
Diabetes, May 1, 2004; 53(5): 1222 - 1229.
[Abstract] [Full Text] [PDF]

C.-H. Chung, W.-B. Wu, and T.-F. Huang
Aggretin, a snake venom-derived endothelial integrin {alpha}2{beta}1 agonist, induces angiogenesis via expression of vascular endothelial growth factor
Blood, March 15, 2004; 103(6): 2105 - 2113.
[Abstract] [Full Text] [PDF]

H. Yoshitomi and K. S. Zaret
Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a
Development, February 15, 2004; 131(4): 807 - 817.
[Abstract] [Full Text] [PDF]

R. Martin, R. Lahlil, A. Damert, L. Miquerol, A. Nagy, G. Keller, and T. Hoang
SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis
Development, February 1, 2004; 131(3): 693 - 702.
[Abstract] [Full Text] [PDF]

D. Okamura, T. Kimura, T. Nakano, and Y. Matsui
Cadherin-mediated cell interaction regulates germ cell determination in mice
Development, December 29, 2003; 130(26): 6423 - 6430.
[Abstract] [Full Text] [PDF]

M. Hirashima, Y. Lu, L. Byers, and J. Rossant
Trophoblast expression of fms-like tyrosine kinase 1 is not required for the establishment of the maternal-fetal interface in the mouse placenta
PNAS, December 23, 2003; 100(26): 15637 - 15642.
[Abstract] [Full Text] [PDF]

L.-J. Duan, A. Nagy, and G.-H. Fong
Gastrulation and Angiogenesis, Not Endothelial Specification, Is Sensitive to Partial Deficiency in Vascular Endothelial Growth Factor-A in Mice
Biol Reprod, December 1, 2003; 69(6): 1852 - 1858.
[Abstract] [Full Text] [PDF]

D. P. Griese, A. Ehsan, L. G. Melo, D. Kong, L. Zhang, M. J. Mann, R. E. Pratt, R. C. Mulligan, and V. J. Dzau
Isolation and Transplantation of Autologous Circulating Endothelial Cells Into Denuded Vessels and Prosthetic Grafts: Implications for Cell-Based Vascular Therapy
Circulation, November 25, 2003; 108(21): 2710 - 2715.
[Abstract] [Full Text] [PDF]

J. S. Beebe, J. P. Jani, E. Knauth, P. Goodwin, C. Higdon, A. M. Rossi, E. Emerson, M. Finkelstein, E. Floyd, S. Harriman, et al.
Pharmacological Characterization of CP-547,632, a Novel Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor for Cancer Therapy
Cancer Res., November 1, 2003; 63(21): 7301 - 7309.
[Abstract] [Full Text] [PDF]

H. J. Fehling, G. Lacaud, A. Kubo, M. Kennedy, S. Robertson, G. Keller, and V. Kouskoff
Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation
Development, September 1, 2003; 130(17): 4217 - 4227.
[Abstract] [Full Text] [PDF]

R. F. de Pooter, S. K. Cho, J. R. Carlyle, and J. C. Zuniga-Pflucker
In vitro generation of T lymphocytes from embryonic stem cell-derived prehematopoietic progenitors
Blood, September 1, 2003; 102(5): 1649 - 1653.
[Abstract] [Full Text] [PDF]

M. Moser, O. Binder, Y. Wu, J. Aitsebaomo, R. Ren, C. Bode, V. L. Bautch, F. L. Conlon, and C. Patterson
BMPER, a Novel Endothelial Cell Precursor-Derived Protein, Antagonizes Bone Morphogenetic Protein Signaling and Endothelial Cell Differentiation
Mol. Cell. Biol., August 15, 2003; 23(16): 5664 - 5679.
[Abstract] [Full Text] [PDF]

Y. Wu, M. Moser, V. L. Bautch, and C. Patterson
HoxB5 Is an Upstream Transcriptional Switch for Differentiation of the Vascular Endothelium from Precursor Cells
Mol. Cell. Biol., August 15, 2003; 23(16): 5680 - 5691.
[Abstract] [Full Text] [PDF]

N. Nakayama, D. Duryea, R. Manoukian, G. Chow, and C.-y. E. Han
Macroscopic cartilage formation with embryonic stem-cell-derived mesodermal progenitor cells
J. Cell Sci., May 15, 2003; 116(10): 2015 - 2028.
[Abstract] [Full Text] [PDF]

R. C.R. Perlingeiro, M. Kyba, S. Bodie, and G. Q. Daley
A Role for Thrombopoietin in Hemangioblast Development
Stem Cells, May 1, 2003; 21(3): 272 - 280.
[Abstract] [Full Text] [PDF]

S. G. Nir, R. David, M. Zaruba, W.-M. Franz, and J. Itskovitz-Eldor
Human embryonic stem cells for cardiovascular repair
Cardiovasc Res, May 1, 2003; 58(2): 313 - 323.
[Abstract] [Full Text] [PDF]

M. Hirashima, M. Ogawa, S. Nishikawa, K. Matsumura, K. Kawasaki, M. Shibuya, and S.-I. Nishikawa
A chemically defined culture of VEGFR2+ cells derived from embryonic stem cells reveals the role of VEGFR1 in tuning the threshold for VEGF in developing endothelial cells
Blood, March 15, 2003; 101(6): 2261 - 2267.
[Abstract] [Full Text] [PDF]

A. Damert, L. Miquerol, M. Gertsenstein, W. Risau, and A. Nagy
Insufficient VEGFA activity in yolk sac endoderm compromises haematopoietic and endothelial differentiation
Development, March 6, 2003; 129(8): 1881 - 1892.
[Abstract] [Full Text] [PDF]

M. L. Kalev-Zylinska, J. A. Horsfield, M. V. C. Flores, J. H. Postlethwait, M. R. Vitas, A. M. Baas, P. S. Crosier, and K. E. Crosier
Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis
Development, March 6, 2003; 129(8): 2015 - 2030.
[Abstract] [Full Text] [PDF]

G. Elvert, A. Kappel, R. Heidenreich, U. Englmeier, S. Lanz, T. Acker, M. Rauter, K. Plate, M. Sieweke, G. Breier, et al.
Cooperative Interaction of Hypoxia-inducible Factor-2alpha (HIF-2alpha ) and Ets-1 in the Transcriptional Activation of Vascular Endothelial Growth Factor Receptor-2 (Flk-1)
J. Biol. Chem., February 21, 2003; 278(9): 7520 - 7530.
[Abstract] [Full Text] [PDF]

H. Hirai, M. Ogawa, N. Suzuki, M. Yamamoto, G. Breier, O. Mazda, J. Imanishi, and S.-I. Nishikawa
Hemogenic and nonhemogenic endothelium can be distinguished by the activity of fetal liver kinase (Flk)-1 promoter/enhancer during mouse embryogenesis
Blood, February 1, 2003; 101(3): 886 - 893.
[Abstract] [Full Text] [PDF]

M. Jackson, J. W. Baird, N. Cambray, J. D. Ansell, L. M. Forrester, and G. J. Graham
Cloning and Characterization of Ehox, a Novel Homeobox Gene Essential for Embryonic Stem Cell Differentiation
J. Biol. Chem., October 4, 2002; 277(41): 38683 - 38692.
[Abstract] [Full Text] [PDF]

F. A. Scappaticci
Mechanisms and Future Directions for Angiogenesis-Based Cancer Therapies
J. Clin. Oncol., September 15, 2002; 20(18): 3906 - 3927.
[Abstract] [Full Text] [PDF]

				G. Narazaki, H. Uosaki, M. Teranishi, K. Okita, B. Kim, S. Matsuoka, S. Yamanaka, and J. K. Yamashita Directed and Systematic Differentiation of Cardiovascular Cells From Mouse Induced Pluripotent Stem Cells Circulation, July 29, 2008; 118(5): 498 - 506. [Abstract] [Full Text] [PDF]

				T. J. Nelson, R. S. Faustino, A. Chiriac, R. Crespo-Diaz, A. Behfar, and A. Terzic CXCR4+/FLK-1+ Biomarkers Select a Cardiopoietic Lineage from Embryonic Stem Cells Stem Cells, June 1, 2008; 26(6): 1464 - 1473. [Abstract] [Full Text] [PDF]

				K. Yanagi, M. Takano, G. Narazaki, H. Uosaki, T. Hoshino, T. Ishii, T. Misaki, and J. K. Yamashita Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels and T-Type Calcium Channels Confer Automaticity of Embryonic Stem Cell-Derived Cardiomyocytes Stem Cells, November 1, 2007; 25(11): 2712 - 2719. [Abstract] [Full Text] [PDF]

				M. M. Bakre, A. Hoi, J. C. Y. Mong, Y. Y. Koh, K. Y. Wong, and L. W. Stanton Generation of Multipotential Mesendodermal Progenitors from Mouse Embryonic Stem Cells via Sustained Wnt Pathway Activation J. Biol. Chem., October 26, 2007; 282(43): 31703 - 31712. [Abstract] [Full Text] [PDF]

				R. C. R. Perlingeiro Endoglin is required for hemangioblast and early hematopoietic development Development, August 15, 2007; 134(16): 3041 - 3048. [Abstract] [Full Text] [PDF]

				M. Kennedy, S. L. D'Souza, M. Lynch-Kattman, S. Schwantz, and G. Keller Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures Blood, April 1, 2007; 109(7): 2679 - 2687. [Abstract] [Full Text] [PDF]

				P. McGannon, Y. Miyazaki, P. C. Gupta, E. I. Traboulsi, and C. Colmenares Ocular Abnormalities in Mice Lacking the Ski Proto-oncogene. Invest. Ophthalmol. Vis. Sci., October 1, 2006; 47(10): 4231 - 4237. [Abstract] [Full Text] [PDF]

				A. Ishimura, J. K. Ng, M. Taira, S. G. Young, and S.-I. Osada Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor {beta} signaling Development, October 1, 2006; 133(19): 3919 - 3928. [Abstract] [Full Text] [PDF]

				Y. Chen, I. Amende, T. G. Hampton, Y. Yang, Q. Ke, J.-Y. Min, Y.-F. Xiao, and J. P. Morgan Vascular endothelial growth factor promotes cardiomyocyte differentiation of embryonic stem cells Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1653 - H1658. [Abstract] [Full Text] [PDF]

				C. Park, K. Lavine, Y. Mishina, C.-X. Deng, D. M. Ornitz, and K. Choi Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation Development, September 1, 2006; 133(17): 3473 - 3484. [Abstract] [Full Text] [PDF]

				M. Abe and Y. Sato Puromycin insensitive leucyl-specific aminopeptidase (PILSAP) is required for the development of vascular as well as hematopoietic system in embryoid bodies. Genes Cells, July 1, 2006; 11(7): 719 - 729. [Abstract] [Full Text] [PDF]

				D. Mehta and A. B. Malik Signaling Mechanisms Regulating Endothelial Permeability Physiol Rev, January 1, 2006; 86(1): 279 - 367. [Abstract] [Full Text] [PDF]

				M. Ema, S. Takahashi, and J. Rossant Deletion of the selection cassette, but not cis-acting elements, in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors Blood, January 1, 2006; 107(1): 111 - 117. [Abstract] [Full Text] [PDF]

				S. Taoudi, A. M. Morrison, H. Inoue, R. Gribi, J. Ure, and A. Medvinsky Progressive divergence of definitive haematopoietic stem cells from the endothelial compartment does not depend on contact with the foetal liver Development, September 15, 2005; 132(18): 4179 - 4191. [Abstract] [Full Text] [PDF]

				K. Hamada, T. Sasaki, P. A. Koni, M. Natsui, H. Kishimoto, J. Sasaki, N. Yajima, Y. Horie, G. Hasegawa, M. Naito, et al. The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis Genes & Dev., September 1, 2005; 19(17): 2054 - 2065. [Abstract] [Full Text] [PDF]

				L. Campagnolo, A. Leahy, S. Chitnis, S. Koschnick, M. J. Fitch, J. T. Fallon, D. Loskutoff, M. B. Taubman, and H. Stuhlmann EGFL7 Is a Chemoattractant for Endothelial Cells and Is Up-Regulated in Angiogenesis and Arterial Injury Am. J. Pathol., July 1, 2005; 167(1): 275 - 284. [Abstract] [Full Text] [PDF]

				G. Keller Embryonic stem cell differentiation: emergence of a new era in biology and medicine Genes & Dev., May 15, 2005; 19(10): 1129 - 1155. [Abstract] [Full Text] [PDF]

				S. L. D'Souza, A. G. Elefanty, and G. Keller SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development Blood, May 15, 2005; 105(10): 3862 - 3870. [Abstract] [Full Text] [PDF]

				L.-J. Duan, Y. Zhang-Benoit, and G.-H. Fong Endothelium-Intrinsic Requirement for Hif-2{alpha} During Vascular Development Circulation, May 3, 2005; 111(17): 2227 - 2232. [Abstract] [Full Text] [PDF]

				M. Iida, T. Heike, M. Yoshimoto, S. Baba, H. Doi, and T. Nakahata Identification of cardiac stem cells with FLK1, CD31, and VE-cadherin expression during embryonic stem cell differentiation FASEB J, March 1, 2005; 19(3): 371 - 378. [Abstract] [Full Text] [PDF]

				M. Eguchi, M. Eguchi-Ishimae, A. Green, T. Enver, and M. Greaves Directing oncogenic fusion genes into stem cells via an SCL enhancer PNAS, January 25, 2005; 102(4): 1133 - 1138. [Abstract] [Full Text] [PDF]

				H. T. Ku, N. Zhang, A. Kubo, R. O'Connor, M. Mao, G. Keller, and J. S. Bromberg Committing Embryonic Stem Cells to Early Endocrine Pancreas In Vitro Stem Cells, December 1, 2004; 22(7): 1205 - 1217. [Abstract] [Full Text] [PDF]

				I. NILSSON, C. ROLNY, Y. WU, B. PYTOWSKI, D. HICKLIN, K. ALITALO, L. CLAESSON-WELSH, and S. WENNSTROM Vascular endothelial growth factor receptor-3 in hypoxia-induced vascular development FASEB J, October 1, 2004; 18(13): 1507 - 1515. [Abstract] [Full Text] [PDF]

				E.A.V. Jones, M.H. Baron, S.E. Fraser, and M.E. Dickinson Measuring hemodynamic changes during mammalian development Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1561 - H1569. [Abstract] [Full Text] [PDF]

				A. Zippo, A. De Robertis, M. Bardelli, F. Galvagni, and S. Oliviero Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro Blood, June 15, 2004; 103(12): 4536 - 4544. [Abstract] [Full Text] [PDF]

				T. Chan-Ling, D. S. McLeod, S. Hughes, L. Baxter, Y. Chu, T. Hasegawa, and G. A. Lutty Astrocyte-Endothelial Cell Relationships during Human Retinal Vascular Development Invest. Ophthalmol. Vis. Sci., June 1, 2004; 45(6): 2020 - 2032. [Abstract] [Full Text] [PDF]

				C. Park, I. Afrikanova, Y. S. Chung, W. J. Zhang, E. Arentson, G. h. Fong, A. Rosendahl, and K. Choi A hierarchical order of factors in the generation of FLK1- and SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells Development, June 1, 2004; 131(11): 2749 - 2762. [Abstract] [Full Text] [PDF]

				Y. Sassa, Y. Hata, L. P. Aiello, Y. Taniguchi, K. Kohno, and T. Ishibashi Bifunctional Properties of Peroxisome Proliferator-Activated Receptor {gamma}1 in KDR Gene Regulation Mediated via Interaction With Both Sp1 and Sp3 Diabetes, May 1, 2004; 53(5): 1222 - 1229. [Abstract] [Full Text] [PDF]

				C.-H. Chung, W.-B. Wu, and T.-F. Huang Aggretin, a snake venom-derived endothelial integrin {alpha}2{beta}1 agonist, induces angiogenesis via expression of vascular endothelial growth factor Blood, March 15, 2004; 103(6): 2105 - 2113. [Abstract] [Full Text] [PDF]

				H. Yoshitomi and K. S. Zaret Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a Development, February 15, 2004; 131(4): 807 - 817. [Abstract] [Full Text] [PDF]