Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants

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Endogenous bone morphogenetic proteins regulate outgrowth and epithelial survival during avian lip fusion
Development, January 10, 2002; 129(19): 4647 - 4660.
[Abstract] [Full Text] [PDF]

A. Hatoum, M. E. El-Sabban, J. Khoury, S. H. Yuspa, and N. Darwiche
Overexpression of retinoic acid receptors alpha and gamma into neoplastic epidermal cells causes retinoic acid-induced growth arrest and apoptosis
Carcinogenesis, December 1, 2001; 22(12): 1955 - 1963.
[Abstract] [Full Text] [PDF]

Genetically Modified Animals in Endocrinology
Endocr. Rev., October 1, 2001; 22(5): 719 - 720.
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R. A. Schneider, D. Hu, J. L. R. Rubenstein, M. Maden, and J. A. Helms
Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH
Development, July 15, 2001; 128(14): 2755 - 2767.
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O. Wendling, N. B. Ghyselinck, P. Chambon, and M. Mark
Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning
Development, June 1, 2001; 128(11): 2031 - 2038.
[Abstract] [Full Text] [PDF]

M. Mori, N. B. Ghyselinck, P. Chambon, and M. Mark
Systematic Immunolocalization of Retinoid Receptors in Developing and Adult Mouse Eyes
Invest. Ophthalmol. Vis. Sci., May 1, 2001; 42(6): 1312 - 1318.
[Abstract] [Full Text]

P. Kastner, H. J. Lawrence, C. Waltzinger, N. B. Ghyselinck, P. Chambon, and S. Chan
Positive and negative regulation of granulopoiesis by endogenous RAR{alpha}
Blood, March 1, 2001; 97(5): 1314 - 1320.
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A. C.-K. Chung, D. Katz, F. A. Pereira, K. J. Jackson, F. J. DeMayo, A. J. Cooney, and B. W. O'Malley
Loss of Orphan Receptor Germ Cell Nuclear Factor Function Results in Ectopic Development of the Tail Bud and a Novel Posterior Truncation
Mol. Cell. Biol., January 15, 2001; 21(2): 663 - 677.
[Abstract] [Full Text]

S. Abu-Abed, P. Dollé, D. Metzger, B. Beckett, P. Chambon, and M. Petkovich
The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures
Genes & Dev., January 15, 2001; 15(2): 226 - 240.
[Abstract] [Full Text]

M Li, H Chiba, X Warot, N Messaddeq, C Gerard, P Chambon, and D Metzger
RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations
Development, January 3, 2001; 128(5): 675 - 688.
[Abstract] [PDF]

Z. Fu, H. Kato, K. Sugahara, and T. Kubo
Retinoic Acid Accelerates the Development of Reproductive Organs and Egg Production in Japanese Quail (Coturnix coturnix japonica)
Biol Reprod, December 1, 2000; 63(6): 1795 - 1800.
[Abstract] [Full Text]

M. Liu, F. A. Pereira, S. D. Price, M.-j. Chu, C. Shope, D. Himes, R. A. Eatock, W. E. Brownell, A. Lysakowski, and M.-J. Tsai
Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems
Genes & Dev., November 15, 2000; 14(22): 2839 - 2854.
[Abstract] [Full Text]

				P. Rantakari, L. Strauss, R. Kiviranta, H. Lagerbohm, J. Paviala, I. Holopainen, S. Vainio, P. Pakarinen, and M. Poutanen Placenta Defects and Embryonic Lethality Resulting from Disruption of Mouse Hydroxysteroid (17-{beta}) Dehydrogenase 2 Gene Mol. Endocrinol., March 1, 2008; 22(3): 665 - 675. [Abstract] [Full Text] [PDF]

				Y.-K. Kim, L. Wassef, L. Hamberger, R. Piantedosi, K. Palczewski, W. S. Blaner, and L. Quadro Retinyl Ester Formation by Lecithin:Retinol Acyltransferase Is a Key Regulator of Retinoid Homeostasis in Mouse Embryogenesis J. Biol. Chem., February 29, 2008; 283(9): 5611 - 5621. [Abstract] [Full Text] [PDF]

				N. Wiper-Bergeron, C. St-Louis, and J. M. Lee CCAAT/Enhancer Binding Protein {beta} Abrogates Retinoic Acid-Induced Osteoblast Differentiation via Repression of Runx2 Transcription Mol. Endocrinol., September 1, 2007; 21(9): 2124 - 2135. [Abstract] [Full Text] [PDF]

				S. Zhongyi, P. Rantakari, T. Lamminen, J. Toppari, and M. Poutanen Transgenic Male Mice Expressing Human Hydroxysteroid Dehydrogenase 2 Indicate a Role for the Enzyme Independent of Its Action on Sex Steroids Endocrinology, August 1, 2007; 148(8): 3827 - 3836. [Abstract] [Full Text] [PDF]

				C. Roberts, S. Ivins, A. C. Cook, A. Baldini, and P. J. Scambler Cyp26 genes a1, b1 and c1 are down-regulated in Tbx1 null mice and inhibition of Cyp26 enzyme function produces a phenocopy of DiGeorge Syndrome in the chick Hum. Mol. Genet., December 1, 2006; 15(23): 3394 - 3410. [Abstract] [Full Text] [PDF]

				P. McGannon, Y. Miyazaki, P. C. Gupta, E. I. Traboulsi, and C. Colmenares Ocular Abnormalities in Mice Lacking the Ski Proto-oncogene. Invest. Ophthalmol. Vis. Sci., October 1, 2006; 47(10): 4231 - 4237. [Abstract] [Full Text] [PDF]

				L. M. Hoffman, K. Garcha, K. Karamboulas, M. F. Cowan, L. M. Drysdale, W. A. Horton, and T. M. Underhill BMP action in skeletogenesis involves attenuation of retinoid signaling J. Cell Biol., July 3, 2006; 174(1): 101 - 113. [Abstract] [Full Text] [PDF]

				G. S. Daftary and H. S. Taylor Endocrine Regulation of HOX Genes Endocr. Rev., June 1, 2006; 27(4): 331 - 355. [Abstract] [Full Text] [PDF]

				A. Molotkov, N. Molotkova, and G. Duester Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterning Development, May 15, 2006; 133(10): 1901 - 1910. [Abstract] [Full Text] [PDF]

				V. Ribes, Z. Wang, P. Dolle, and K. Niederreither Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling Development, January 15, 2006; 133(2): 351 - 361. [Abstract] [Full Text] [PDF]

				Y. Wang, E. Vachon, J. Zhang, V. Cherepanov, J. Kruger, J. Li, K. Saito, P. Shannon, N. Bottini, H. Huynh, et al. Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function J. Exp. Med., December 5, 2005; 202(11): 1587 - 1597. [Abstract] [Full Text] [PDF]

				Genetically Modified Animals in Endocrinology Endocr. Rev., December 1, 2005; 26(7): 985 - 993. [Abstract] [Full Text] [PDF]

				N. Matt, V. Dupe, J.-M. Garnier, C. Dennefeld, P. Chambon, M. Mark, and N. B. Ghyselinck Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells Development, November 1, 2005; 132(21): 4789 - 4800. [Abstract] [Full Text] [PDF]

				L. Quadro, L. Hamberger, M. E. Gottesman, F. Wang, V. Colantuoni, W. S. Blaner, and C. L. Mendelsohn Pathways of Vitamin A Delivery to the Embryo: Insights from a New Tunable Model of Embryonic Vitamin A Deficiency Endocrinology, October 1, 2005; 146(10): 4479 - 4490. [Abstract] [Full Text] [PDF]

				A. P. Brogan, T. J. Dickerson, G. E. Boldt, and K. D. Janda Altered retinoid homeostasis catalyzed by a nicotine metabolite: Implications in macular degeneration and normal development PNAS, July 26, 2005; 102(30): 10433 - 10438. [Abstract] [Full Text] [PDF]

				A. Szanto and L. Nagy Retinoids Potentiate Peroxisome Proliferator-Activated Receptor {gamma} Action in Differentiation, Gene Expression, and Lipid Metabolic Processes in Developing Myeloid Cells Mol. Pharmacol., June 1, 2005; 67(6): 1935 - 1943. [Abstract] [Full Text] [PDF]

				M. A. Meester-Smoor, M. Vermeij, M. J. L. van Helmond, A. C. Molijn, K. H. M. van Wely, A. C. P. Hekman, C. Vermey-Keers, P. H. J. Riegman, and E. C. Zwarthoff Targeted Disruption of the Mn1 Oncogene Results in Severe Defects in Development of Membranous Bones of the Cranial Skeleton Mol. Cell. Biol., May 15, 2005; 25(10): 4229 - 4236. [Abstract] [Full Text] [PDF]

				C. F. Chen and D. Lohnes Dominant-negative Retinoic Acid Receptors Elicit Epidermal Defects through a Non-canonical Pathway J. Biol. Chem., January 28, 2005; 280(4): 3012 - 3021. [Abstract] [Full Text] [PDF]

				J. Dubrulle and O. Pourquie Coupling segmentation to axis formation Development, December 1, 2004; 131(23): 5783 - 5793. [Abstract] [Full Text] [PDF]

				M. Houle, J.-R. Sylvestre, and D. Lohnes Retinoic acid regulates a subset of Cdx1 function in vivo Development, December 29, 2003; 130(26): 6555 - 6567. [Abstract] [Full Text] [PDF]

				V. Dupe, N. Matt, J.-M. Garnier, P. Chambon, M. Mark, and N. B. Ghyselinck A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment PNAS, November 25, 2003; 100(24): 14036 - 14041. [Abstract] [Full Text] [PDF]

				J. Zhang, D. Smith, M. Yamamoto, L. Ma, and P. McCaffery The Meninges Is a Source of Retinoic Acid for the Late-Developing Hindbrain J. Neurosci., August 20, 2003; 23(20): 7610 - 7620. [Abstract] [Full Text] [PDF]

				X. Fan, A. Molotkov, S.-I. Manabe, C. M. Donmoyer, L. Deltour, M. H. Foglio, A. E. Cuenca, W. S. Blaner, S. A. Lipton, and G. Duester Targeted Disruption of Aldh1a1 (Raldh1) Provides Evidence for a Complex Mechanism of Retinoic Acid Synthesis in the Developing Retina Mol. Cell. Biol., July 1, 2003; 23(13): 4637 - 4648. [Abstract] [Full Text] [PDF]

				K. Niederreither, J. Vermot, I. L. Roux, B. Schuhbaur, P. Chambon, and P. Dolle The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system Development, June 1, 2003; 130(11): 2525 - 2534. [Abstract] [Full Text] [PDF]

				A. Halilagic, M. H. Zile, and M. Studer A novel role for retinoids in patterning the avian forebrain during presomite stages Development, May 15, 2003; 130(10): 2039 - 2050. [Abstract] [Full Text] [PDF]

				J. M. Lampert, J. Holzschuh, S. Hessel, W. Driever, K. Vogt, and J. von Lintig Provitamin A conversion to retinal via the {beta},{beta}-carotene-15,15'-oxygenase (bcox) is essential for pattern formation and differentiation during zebrafish embryogenesis Development, May 15, 2003; 130(10): 2173 - 2186. [Abstract] [Full Text] [PDF]

				A. D. Weston, B. Blumberg, and T. M. Underhill Active repression by unliganded retinoid receptors in development: less is sometimes more J. Cell Biol., April 28, 2003; 161(2): 223 - 228. [Abstract] [Full Text] [PDF]

				L. M. Hoffman, A. D. Weston, and T. M. Underhill Molecular Mechanisms Regulating Chondroblast Differentiation J. Bone Joint Surg. Am., April 28, 2003; 85(90002): 124 - 132. [Abstract] [Full Text]

				D. L. Thompson, L. M. Gerlach-Bank, K. F. Barald, and R. J. Koenig Retinoic Acid Repression of Bone Morphogenetic Protein 4 in Inner Ear Development Mol. Cell. Biol., April 1, 2003; 23(7): 2277 - 2286. [Abstract] [Full Text] [PDF]

				S. Abu-Abed, P. Dolle, D. Metzger, C. Wood, G. MacLean, P. Chambon, and M. Petkovich Developing with lethal RA levels: genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1 Development, April 1, 2003; 130(7): 1449 - 1459. [Abstract] [Full Text] [PDF]