Products, genetic linkage and limb patterning activity of a murine hedgehog gene

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Chang, D. T.
	Articles by Beachy, P. A.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Chang, D. T.
	Articles by Beachy, P. A.

Baker, N. E (1988). Embryonic and imaginal requirements for wingless , a segment polarity gene in Drosophila. Dev. Biol 125, 96-108.[Medline]

Bejsovec, A. and Martinez-Arias, A (1991). Roles of wingless in patterning the larval epidermis of Drosophila. Development 113, 471-485.[Abstract]

Bejsovec, A. and Wieschaus, E (1993). Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos. Development 119, 501-517.[Abstract]

Bishop, D. T (1985). The information content of phase-known matings for ordering genetic loci. Genet. Epidemiol 2, 349-361.[Medline]

Burnette, W. N (1981). Western blotting: electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radio-iodinated Protein A. Anal. Biochem 112, 195-203.[Medline]

Chen, C. and Okayama, H (1987). High-efficiency transformation of mammalian cells by plasmid DNA. Molecular & Cellular Biology 7, 2745-2752.[Abstract/Free Full Text]

DiNardo, S., Sher, E., Heemskerk-Jongens, J., Kassis, J. A. and O'Farrell, P. H (1988). Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis. Nature 332, 604-609.[Medline]

Dougan, S. and DiNardo, S (1992). Drosophilawingless generates cell type diversity among engrailed expressing cells. Nature 360, 347-50.[Medline]

Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A. and McMahon, A. P (1993). Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430.[Medline]

Feinberg, A. and Vogelstein, B (1983). A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem 132, 6-13.[Medline]

Ferguson, E. L. and Anderson, K. V (1992). Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo. Cell 71, 451-461.[Medline]

Forbes, A. J., Nakano, Y., Taylor, A. M. and Ingham, P. W (1993). Genetic analysis of hedgehog signalling in the Drosophila embryo. Development 1993, 115-124.

Heberlein, U., Wolff, T. and Rubin, G. M (1993). The TGF beta homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina. Cell 75, 913-926.[Medline]

Heemskerk, J. and DiNardo, S (1994). Drosophila hedgehog acts as a morphogen in cellular patterning. Cell 76, 449-460.[Medline]

Heutink, P., Zguricas, J., Oosterhout, L. v., Breedveld, G. J., Testers, L., Sandkuijl, L. A., Snijders, P. J. L. M., Weissenbach, J., Lindhout, D., Hovius, S. E. R. and Oostra, B. A (1994). The gene for triphalangeal thumb maps to the subtelomeric region of chromosome 7q. Nature Genetics 6, 287-292.[Medline]

Ingham, P. W (1993). Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo. Nature 366, 560-562.[Medline]

Ingham, P. W., Taylor, A. M. and Nakano, Y (1991). Role of the Drosophila patched gene in positional signalling. Nature 353, 184-187.[Medline]

Knudsen, T. B. and Kochhar, D. M (1981). The role of morphogenetic cell death during abnormal limb-bud outgrowth in mice heterozygous for the dominant mutation Hemimelia-extra toe ( Hmx ). J. Embryol. Exp. Morphol 65, 289-307.

Kozak, C. A. and Stephenson, D. A (1993). Mouse chromosome 5. Mammalian Genome 4, 72-87.

Krauss, S., Concordet, J.-P. and Ingham, P. W (1993). A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell 75, 1431-1444.[Medline]

Laemmli, U. K (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.[Medline]

Lee, J. J., von Kessler, D. P., Park, S. and Beachy, P. A (1992). Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell 71, 33-50.[Medline]

Lee, S. J (1990). Identification of a novel member (GDF-1) of the transforming growth factor-superfamily. Mol. Endocrinol 4, 1034-1040.[Abstract]

Lockyer, J., Cook, R. G., Milatien, S., Kaufman, S., Woo, S. L. C. and Ledley, F. D (1987). Structure and expression of human dihydropteridine reductase. Proc. Natl. Acad. Sci. USA 84, 3329-3333.[Abstract/Free Full Text]

Ma, C., Zhou, Y., Beachy, P. A. and Moses, K (1993). The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye. Cell 75, 927-938.[Medline]

Martinez Arias, A., Baker, N. E. and Ingham, P. W (1988). Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo. Development 103, 157-170.[Abstract]

Mock, B. A., Nordan, R. P., Justice, M. J., Kozak, C., Jenkins, N. A., Copeland, N. G., Clark, S. C., Wong, G. G. and Rudlkoff, S (1989). The murine Il-6 gene maps to the proximal region of Chromosome 5. Journal of Immunology 142, 1372-1376.[Abstract]

Mohler, J (1988). Requirements for hedgehog , a segmental polarity gene, in patterning larval and adult cuticle of Drosophila. Genetics 120, 1061-1072.[Abstract/Free Full Text]

Mohler, J. and Vani, K (1992). Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning in Drosophila. Development 115, 957-971.[Abstract]

Moscovici, C., Moscovici, M. G., Jimenez, H., Lai, M. M., Hayman, M. J. and Vogt, P. K (1977). Continuous tissue culture cell lines derived from chemically induced tumors of Japanese quail. Cell 11, 95-103.[Medline]

Nusse, R. and Varmus, H. E (1992). Wnt genes. Cell 69, 1073-1087.[Medline]

Peifer, M. and Bejsovec, A (1992). Knowing your neighbors: cell interactions determine intrasegmental patterning in Drosophila. Trends in Genetics 8, 243-249.

Placzek, M., Jessell, T. M., and Dodd, J (1993). Induction of floor plate differentiation by contact-dependent homeogenetic signals. Development 117, 205-218.[Abstract]

Riddle, D. R., Johnson, R. L., Laufer, E. and Tabin, C (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.[Medline]

Rijsewijk, F., Schuermann, M., Wagenaar, E., Parren, P., Weigel, D. and Nusse, R (1987). The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell 50, 649-657.[Medline]

Riley, B. B., Savage, M. P., Simandl, B. K., Olwin, B. B. and Fallon, J. F (1993). Retroviral expression of FGF-2 (bFGF) affects patterning in chick limb bud. Development 118, 95-104.[Abstract]

Roelink, H., Augsburger, A., Heemskerk, J., Korzh, V., Norlin, S., Ruiz i Altaba, A., Tanabe, Y., Placzek, M., Edlund, T., Jessell, T. M. and Dodd, J (1994). Floor plate and motor neuron induction by vhh-1 , a vertebrate homolg of hedgehog expressed by the notochord. Cell 76, 761-775.[Medline]

Rubin, G. M. and Spradling, A. C (1982). Genetic transformation of Drosophila with transposable element vectors. Science 218, 348-353.[Abstract/Free Full Text]

Sanger, F., Nicklen, S. and Coulson, A. R (1977). DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74, 5463-5467.[Abstract/Free Full Text]

Saunders, A. M. and Seldin, M. F (1990). A molecular genetic linkage map of mouse chromosome 7. Genomics 8, 524-535.

Schimmang, T., Lemaistre, M., Vortkamp, A. and Ruther, U (1992). Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes ( Xt ). Development 116, 799-804.[Abstract]

Schubert, F. R., Nieselt-Struwe, K. and Gruss, P (1993). The Antennapedia-type homeobox genes have evolved from three precursors separated early in metazoan evolution. Proc. Natl. Acad. Sci. USA 90, 143-147.[Abstract/Free Full Text]

Seldin, M. F., Morse, H. C., Reeves, J. P., Scribner, J. P., LeBoeuf, R. C. and Steinber, A. D (1988). Genetic analysis of autoimmune gld mice I. Identification of a restriction fragment length polymorphism closely linked to the gld mutation within a conserved linkage group. J. Exp. Med 167, 688-693.[Abstract/Free Full Text]

Tabata, T., Eaton, S. and Kornberg, T (1992). The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. Genes Dev 6, 2635-2645.[Abstract/Free Full Text]

Tabata, T. and Kornberg, T. B (1994). Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 76, 89-102.[Medline]

Tashiro, S., Michiue, T., Higashijima, S., Zenno, S., Ishimaru, S., Takahashi, F., Orihara, M., Kojima, T. and Saigo, K (1993). Structure and expression of hedgehog , a Drosophila segment polarity gene required for cell-cell communication. Gene 124, 183-189.[Medline]

Tautz, D. and Pfeifle, C (1989). A non-radioactive in situ hybridization method for the localization of specific RNAs in the Drosophila embryo reveals translational control of the segmentation gene hunchback. Chromosoma 98, 81-85.[Medline]

Taylor, A. M., Nakano, Y., Mohler, J. and Ingham, P. W (1993). Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo. Mech. Dev 42, 89-96.[Medline]

Thummel, C. S., Boulet, A. M. and Lipshitz, H. D (1988). Vectors for Drosophila P-element-mediated transformation and tissue culture transfection. Gene 74, 445-456.[Medline]

Tickle, C., Shellswell, G., Crawley, A. and Wolpert, L (1976). Positional signalling by mouse limb polarising region in the chick wing bud. Nature 259, 396-397.[Medline]

Tsukurov, O., Boehmer, A., Flynn, J., Nicolai, J.-P., Hamel, B. C. J., Traill,S., Zaleske, D., Mankin, H. J., Yeon, H., Ho, C., Tabin, C., Seidman, J. G. and Seidman, C (1994). A complex bilateral polysyndactyly disease locus maps to chromosome 7q36. Nature Genetics 6, 282-286.[Medline]

von Heijne, G (1986). A new method for predicting signal sequence cleavage sites. Nucl. Acids Res 14, 4683-4690.[Abstract/Free Full Text]

Wagner, M., Thaller, C., Jessell, T. and Eichele, G (1990). Polarizing activity and retinoid synthesis in the floor plate of the neural tube. Nature 345, 819-822.[Medline]

Watson, M. L., D'Eustachio, P. D., Mock, B. A., Steinberg, A. D., Morse, H. C. I., Oakey, R. J., Howard, T. A., Rochelle, J. M. and Seldin, M. F (1992). A linkage map of mouse chromosome 1 using an interspecific cross segregating for the gld autoimmunity mutation. Mammalian Genome 2, 158-171.[Medline]

Wolpert, L (1969). Positional information and the spatial pattern of cellular differentiation. Journal of Theoretical Biology 25, 1-47.[Medline]

Yamada, T., Pfaff, S. L., Edlund, T., and Jessell, T. M (1993). Control of cell pattern in the neural tube: motor neuron induction by diffusible factors from notochord and floor plate. Cell 73, 673-686.[Medline]

This article has been cited by other articles:

J. G. M. Thewissen, M. J. Cohn, L. S. Stevens, S. Bajpai, J. Heyning, and W. E. Horton Jr.
Developmental basis for hind-limb loss in dolphins and origin of the cetacean bodyplan
PNAS, May 30, 2006; 103(22): 8414 - 8418.
[Abstract] [Full Text] [PDF]

C. H. Evans and R. N. Rosier
Molecular Biology in Orthopaedics: The Advent of Molecular Orthopaedics
J. Bone Joint Surg. Am., November 1, 2005; 87(11): 2550 - 2564.
[Abstract] [Full Text] [PDF]

M. T. Cobourne, I. Miletich, and P. T. Sharpe
Restriction of sonic hedgehog signalling during early tooth development
Development, June 15, 2004; 131(12): 2875 - 2885.
[Abstract] [Full Text] [PDF]

D. O. Walterhouse, M. L.G. Lamm, E. Villavicencio, and P. M. Iannaccone
Emerging Roles for Hedgehog-Patched-Gli Signal Transduction in Reproduction
Biol Reprod, July 1, 2003; 69(1): 8 - 14.
[Abstract] [Full Text] [PDF]

F. Gofflot, C. Hars, F. Illien, F. Chevy, C. Wolf, J. J. Picard, and C. Roux
Molecular mechanisms underlying limb anomalies associated with cholesterol deficiency during gestation: implications of Hedgehog signaling
Hum. Mol. Genet., May 15, 2003; 12(10): 1187 - 1198.
[Abstract] [Full Text] [PDF]

E. C. Bailey, L. Milenkovic, M. P. Scott, J. F. Collawn, and R. L. Johnson
Several PATCHED1 Missense Mutations Display Activity in patched1-Deficient Fibroblasts
J. Biol. Chem., September 6, 2002; 277(37): 33632 - 33640.
[Abstract] [Full Text] [PDF]

R. M. Clark, P. C. Marker, E. Roessler, A. Dutra, J. C. Schimenti, M. Muenke, and D. M. Kingsley
Reciprocal Mouse and Human Limb Phenotypes Caused by Gain- and Loss-of-Function Mutations Affecting Lmbr1
Genetics, October 1, 2001; 159(2): 715 - 726.
[Abstract] [Full Text] [PDF]

M. Dundar, T. M Gordon, I. Ozyazgan, F. Oguzkaya, Y. Ozkul, A. Cooke, A G. Wilkinson, S. Holloway, F. R Goodman, and J. L Tolmie
A novel acropectoral syndrome maps to chromosome 7q36
J. Med. Genet., May 1, 2001; 38(5): 304 - 309.
[Abstract] [Full Text]

M. Fernandez-Teran, M. E. Piedra, I. S. Kathiriya, D. Srivastava, J. C. Rodriguez-Rey, and M. A. Ros
Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway
Development, May 15, 2000; 127(10): 2133 - 2142.
[Abstract] [PDF]

L. Sarkar, M. Cobourne, S. Naylor, M. Smalley, T. Dale, and P. T. Sharpe
Special Feature: Wnt/Shh interactions regulate ectodermal boundary formation during mammalian tooth development
PNAS, April 25, 2000; 97(9): 4520 - 4524.
[Abstract] [Full Text] [PDF]

J. Sanz-Ezquerro and C Tickle
Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development
Development, January 11, 2000; 127(22): 4811 - 4823.
[Abstract] [PDF]

S. C. Tucker and R. Wisdom
Site-specific Heterodimerization by Paired Class Homeodomain Proteins Mediates Selective Transcriptional Responses
J. Biol. Chem., November 5, 1999; 274(45): 32325 - 32332.
[Abstract] [Full Text] [PDF]

N. Fuse, T. Maiti, B. Wang, J. A. Porter, T. M. T. Hall, D. J. Leahy, and P. A. Beachy
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched
PNAS, September 28, 1999; 96(20): 10992 - 10999.
[Abstract] [Full Text] [PDF]

L Lettice, J Hecksher-Sorensen, and R. Hill
The dominant hemimelia mutation uncouples epithelial-mesenchymal interactions and disrupts anterior mesenchyme formation in mouse hindlimbs
Development, January 11, 1999; 126(21): 4729 - 4736.
[Abstract] [PDF]

C. Neumann, H Grandel, W Gaffield, S Schulte-Merker, and C Nusslein-Volhard
Transient establishment of anteroposterior polarity in the zebrafish pectoral fin bud in the absence of sonic hedgehog activity
Development, January 11, 1999; 126(21): 4817 - 4826.
[Abstract] [PDF]

D. Epstein, A. McMahon, and A. Joyner
Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms
Development, January 1, 1999; 126(2): 281 - 292.
[Abstract] [PDF]

I Munoz-Sanjuan, B. Simandl, J. Fallon, and J Nathans
Expression of chicken fibroblast growth factor homologous factor (FHF)-1 and of differentially spliced isoforms of FHF-2 during development and involvement of FHF-2 in chicken limb development
Development, January 1, 1999; 126(2): 409 - 421.
[Abstract] [PDF]

H. Min, D. M. Danilenko, S. A. Scully, B. Bolon, B. D. Ring, J. E. Tarpley, M. DeRose, and W. S. Simonet
Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless
Genes & Dev., October 15, 1998; 12(20): 3156 - 3161.
[Abstract] [Full Text]

G. R. Martin
The roles of FGFs in the early development of vertebrate�limbs
Genes & Dev., June 1, 1998; 12(11): 1571 - 1586.
[Full Text]

M Araujo, M. Piedra, M. Herrera, M. Ros, and M. Nieto
The expression and regulation of chick EphA7 suggests roles in limb patterning and innervation
Development, January 11, 1998; 125(21): 4195 - 4204.
[Abstract] [PDF]

H. Schauerte, F. van Eeden, C Fricke, J Odenthal, U Strahle, and P Haffter
Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish
Development, January 8, 1998; 125(15): 2983 - 2993.
[Abstract] [PDF]

J. Gibson-Brown, S. Agulnik, L. Silver, L Niswander, and V. Papaioannou
Involvement of T-box genes Tbx2-Tbx5 in vertebrate limb specification and development
Development, January 7, 1998; 125(13): 2499 - 2509.
[Abstract] [PDF]

Y. Imokawa and K. Yoshizato
Expression of Sonic hedgehog gene in regenerating newt limb blastemas recapitulates that in developing limb�buds
PNAS, August 19, 1997; 94(17): 9159 - 9164.
[Abstract] [Full Text] [PDF]

E. M. Levine, H. Roelink, J. Turner, and T. A. Reh
Sonic Hedgehog Promotes Rod Photoreceptor Differentiation in Mammalian Retinal Cells In Vitro
J. Neurosci., August 15, 1997; 17(16): 6277 - 6288.
[Abstract] [Full Text] [PDF]

S. Murakami, A. Nifuji, and M. Noda
Expression of Indian Hedgehog in Osteoblasts and Its Posttranscriptional Regulation by Transforming Growth Factor-{beta}
Endocrinology, May 1, 1997; 138(5): 1972 - 1978.
[Abstract] [Full Text] [PDF]

K. Goh, J. Yang, and R. Hynes
Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos
Development, January 11, 1997; 124(21): 4309 - 4319.
[Abstract] [PDF]

V Knezevic, R De Santo, K Schughart, U Huffstadt, C Chiang, K. Mahon, and S Mackem
Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop
Development, January 11, 1997; 124(22): 4523 - 4536.
[Abstract] [PDF]

S Qu, K. Niswender, Q Ji, R van der Meer, D Keeney, M. Magnuson, and R Wisdom
Polydactyly and ectopic ZPA formation in Alx-4 mutant mice
Development, January 10, 1997; 124(20): 3999 - 4008.
[Abstract] [PDF]

C. Peichel, B Prabhakaran, and T. Vogt
The mouse Ulnaless mutation deregulates posterior HoxD gene expression and alters appendicular patterning
Development, January 9, 1997; 124(18): 3481 - 3492.
[Abstract] [PDF]

R Koster, R Stick, F Loosli, and J Wittbrodt
Medaka spalt acts as a target gene of hedgehog signaling
Development, January 8, 1997; 124(16): 3147 - 3156.
[Abstract] [PDF]

J Lee, K. Platt, P Censullo, and A Ruiz i Altaba
Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
Development, January 7, 1997; 124(13): 2537 - 2552.
[Abstract] [PDF]

M. Ros, M Sefton, and M. Nieto
Slug, a zinc finger gene previously implicated in the early patterning of the mesoderm and the neural crest, is also involved in chick limb development
Development, January 5, 1997; 124(9): 1821 - 1829.
[Abstract] [PDF]

R Mo, A. Freer, D. Zinyk, M. Crackower, J Michaud, H. Heng, K. Chik, X. Shi, L. Tsui, S. Cheng, et al.
Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development
Development, January 1, 1997; 124(1): 113 - 123.
[Abstract] [PDF]

R. Zardoya, E. Abouheif, and A. Meyer
Evolutionary analyses of hedgehog and Hoxd-10 genes in fish species closely related to the zebrafish
PNAS, November 12, 1996; 93(23): 13036 - 13041.
[Abstract] [Full Text] [PDF]

M Hammerschmidt, M J Bitgood, and A P McMahon
Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.
Genes & Dev., March 15, 1996; 10(6): 647 - 658.
[Abstract] [PDF]

L V Goodrich, R L Johnson, L Milenkovic, J A McMahon, and M P Scott
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.
Genes & Dev., February 1, 1996; 10(3): 301 - 312.
[Abstract] [PDF]

U Grieshammer, G Minowada, J. Pisenti, U. Abbott, and G. Martin
The chick limbless mutation causes abnormalities in limb bud dorsal-ventral patterning: implications for the mechanism of apical ridge formation
Development, January 12, 1996; 122(12): 3851 - 3861.
[Abstract] [PDF]

J. Concordet, K. Lewis, J. Moore, L. Goodrich, R. Johnson, M. Scott, and P. Ingham
Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning
Development, January 9, 1996; 122(9): 2835 - 2846.
[Abstract] [PDF]

D. Epstein, E Marti, M. Scott, and A. McMahon
Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway
Development, January 9, 1996; 122(9): 2885 - 2894.
[Abstract] [PDF]

M. Ros, A Lopez-Martinez, B. Simandl, C Rodriguez, J. Izpisua Belmonte, R Dahn, and J. Fallon
The limb field mesoderm determines initial limb bud anteroposterior asymmetry and budding independent of sonic hedgehog or apical ectodermal gene expressions
Development, January 8, 1996; 122(8): 2319 - 2330.
[Abstract] [PDF]

A Vogel, C Rodriguez, and J. Izpisua-Belmonte
Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb
Development, January 6, 1996; 122(6): 1737 - 1750.
[Abstract] [PDF]

T Ogura, I. Alvarez, A Vogel, C Rodriguez, R. Evans, and J. Izpisua Belmonte
Evidence that Shh cooperates with a retinoic acid inducible co-factor to establish ZPA-like activity
Development, January 2, 1996; 122(2): 537 - 542.
[Abstract] [PDF]

A E Munsterberg, J Kitajewski, D A Bumcrot, A P McMahon, and A B Lassar
Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite.
Genes & Dev., December 1, 1995; 9(23): 2911 - 2922.
[Abstract] [PDF]

H Masuya, T Sagai, S Wakana, K Moriwaki, and T Shiroishi
A duplicated zone of polarizing activity in polydactylous mouse mutants.
Genes & Dev., July 1, 1995; 9(13): 1645 - 1653.
[Abstract] [PDF]

R. Johnson, J. Grenier, and M. Scott
patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets
Development, January 12, 1995; 121(12): 4161 - 4170.
[Abstract] [PDF]

D. Chan, A Wynshaw-Boris, and P Leder
Formin isoforms are differentially expressed in the mouse embryo and are required for normal expression of fgf-4 and shh in the limb bud
Development, January 10, 1995; 121(10): 3151 - 3162.
[Abstract] [PDF]

S. Ekker, L. McGrew, C. Lai, J. Lee, D. von Kessler, R. Moon, and P. Beachy
Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis
Development, January 8, 1995; 121(8): 2337 - 2347.
[Abstract] [PDF]

C. Lai, S. Ekker, P. Beachy, and R. Moon
Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage
Development, January 8, 1995; 121(8): 2349 - 2360.
[Abstract] [PDF]

E Marti, R Takada, D. Bumcrot, H Sasaki, and A. McMahon
Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo
Development, January 8, 1995; 121(8): 2537 - 2547.
[Abstract] [PDF]

D. Chan, E Laufer, C Tabin, and P Leder
Polydactylous limbs in Strong's Luxoid mice result from ectopic polarizing activity
Development, January 7, 1995; 121(7): 1971 - 1978.
[Abstract] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

				C. H. Evans and R. N. Rosier Molecular Biology in Orthopaedics: The Advent of Molecular Orthopaedics J. Bone Joint Surg. Am., November 1, 2005; 87(11): 2550 - 2564. [Abstract] [Full Text] [PDF]

				M. T. Cobourne, I. Miletich, and P. T. Sharpe Restriction of sonic hedgehog signalling during early tooth development Development, June 15, 2004; 131(12): 2875 - 2885. [Abstract] [Full Text] [PDF]

				D. O. Walterhouse, M. L.G. Lamm, E. Villavicencio, and P. M. Iannaccone Emerging Roles for Hedgehog-Patched-Gli Signal Transduction in Reproduction Biol Reprod, July 1, 2003; 69(1): 8 - 14. [Abstract] [Full Text] [PDF]

				F. Gofflot, C. Hars, F. Illien, F. Chevy, C. Wolf, J. J. Picard, and C. Roux Molecular mechanisms underlying limb anomalies associated with cholesterol deficiency during gestation: implications of Hedgehog signaling Hum. Mol. Genet., May 15, 2003; 12(10): 1187 - 1198. [Abstract] [Full Text] [PDF]

				E. C. Bailey, L. Milenkovic, M. P. Scott, J. F. Collawn, and R. L. Johnson Several PATCHED1 Missense Mutations Display Activity in patched1-Deficient Fibroblasts J. Biol. Chem., September 6, 2002; 277(37): 33632 - 33640. [Abstract] [Full Text] [PDF]

				R. M. Clark, P. C. Marker, E. Roessler, A. Dutra, J. C. Schimenti, M. Muenke, and D. M. Kingsley Reciprocal Mouse and Human Limb Phenotypes Caused by Gain- and Loss-of-Function Mutations Affecting Lmbr1 Genetics, October 1, 2001; 159(2): 715 - 726. [Abstract] [Full Text] [PDF]

				M. Dundar, T. M Gordon, I. Ozyazgan, F. Oguzkaya, Y. Ozkul, A. Cooke, A G. Wilkinson, S. Holloway, F. R Goodman, and J. L Tolmie A novel acropectoral syndrome maps to chromosome 7q36 J. Med. Genet., May 1, 2001; 38(5): 304 - 309. [Abstract] [Full Text]

				M. Fernandez-Teran, M. E. Piedra, I. S. Kathiriya, D. Srivastava, J. C. Rodriguez-Rey, and M. A. Ros Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway Development, May 15, 2000; 127(10): 2133 - 2142. [Abstract] [PDF]

				L. Sarkar, M. Cobourne, S. Naylor, M. Smalley, T. Dale, and P. T. Sharpe Special Feature: Wnt/Shh interactions regulate ectodermal boundary formation during mammalian tooth development PNAS, April 25, 2000; 97(9): 4520 - 4524. [Abstract] [Full Text] [PDF]

				J. Sanz-Ezquerro and C Tickle Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development Development, January 11, 2000; 127(22): 4811 - 4823. [Abstract] [PDF]

				S. C. Tucker and R. Wisdom Site-specific Heterodimerization by Paired Class Homeodomain Proteins Mediates Selective Transcriptional Responses J. Biol. Chem., November 5, 1999; 274(45): 32325 - 32332. [Abstract] [Full Text] [PDF]

				N. Fuse, T. Maiti, B. Wang, J. A. Porter, T. M. T. Hall, D. J. Leahy, and P. A. Beachy Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched PNAS, September 28, 1999; 96(20): 10992 - 10999. [Abstract] [Full Text] [PDF]

				L Lettice, J Hecksher-Sorensen, and R. Hill The dominant hemimelia mutation uncouples epithelial-mesenchymal interactions and disrupts anterior mesenchyme formation in mouse hindlimbs Development, January 11, 1999; 126(21): 4729 - 4736. [Abstract] [PDF]

				C. Neumann, H Grandel, W Gaffield, S Schulte-Merker, and C Nusslein-Volhard Transient establishment of anteroposterior polarity in the zebrafish pectoral fin bud in the absence of sonic hedgehog activity Development, January 11, 1999; 126(21): 4817 - 4826. [Abstract] [PDF]

				D. Epstein, A. McMahon, and A. Joyner Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms Development, January 1, 1999; 126(2): 281 - 292. [Abstract] [PDF]

				I Munoz-Sanjuan, B. Simandl, J. Fallon, and J Nathans Expression of chicken fibroblast growth factor homologous factor (FHF)-1 and of differentially spliced isoforms of FHF-2 during development and involvement of FHF-2 in chicken limb development Development, January 1, 1999; 126(2): 409 - 421. [Abstract] [PDF]

				H. Min, D. M. Danilenko, S. A. Scully, B. Bolon, B. D. Ring, J. E. Tarpley, M. DeRose, and W. S. Simonet Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless Genes & Dev., October 15, 1998; 12(20): 3156 - 3161. [Abstract] [Full Text]

				G. R. Martin The roles of FGFs in the early development of vertebrate�limbs Genes & Dev., June 1, 1998; 12(11): 1571 - 1586. [Full Text]

				M Araujo, M. Piedra, M. Herrera, M. Ros, and M. Nieto The expression and regulation of chick EphA7 suggests roles in limb patterning and innervation Development, January 11, 1998; 125(21): 4195 - 4204. [Abstract] [PDF]

				H. Schauerte, F. van Eeden, C Fricke, J Odenthal, U Strahle, and P Haffter Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish Development, January 8, 1998; 125(15): 2983 - 2993. [Abstract] [PDF]

				J. Gibson-Brown, S. Agulnik, L. Silver, L Niswander, and V. Papaioannou Involvement of T-box genes Tbx2-Tbx5 in vertebrate limb specification and development Development, January 7, 1998; 125(13): 2499 - 2509. [Abstract] [PDF]

				Y. Imokawa and K. Yoshizato Expression of Sonic hedgehog gene in regenerating newt limb blastemas recapitulates that in developing limb�buds PNAS, August 19, 1997; 94(17): 9159 - 9164. [Abstract] [Full Text] [PDF]

				E. M. Levine, H. Roelink, J. Turner, and T. A. Reh Sonic Hedgehog Promotes Rod Photoreceptor Differentiation in Mammalian Retinal Cells In Vitro J. Neurosci., August 15, 1997; 17(16): 6277 - 6288. [Abstract] [Full Text] [PDF]

				S. Murakami, A. Nifuji, and M. Noda Expression of Indian Hedgehog in Osteoblasts and Its Posttranscriptional Regulation by Transforming Growth Factor-{beta} Endocrinology, May 1, 1997; 138(5): 1972 - 1978. [Abstract] [Full Text] [PDF]

				K. Goh, J. Yang, and R. Hynes Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos Development, January 11, 1997; 124(21): 4309 - 4319. [Abstract] [PDF]

				V Knezevic, R De Santo, K Schughart, U Huffstadt, C Chiang, K. Mahon, and S Mackem Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop Development, January 11, 1997; 124(22): 4523 - 4536. [Abstract] [PDF]

				S Qu, K. Niswender, Q Ji, R van der Meer, D Keeney, M. Magnuson, and R Wisdom Polydactyly and ectopic ZPA formation in Alx-4 mutant mice Development, January 10, 1997; 124(20): 3999 - 4008. [Abstract] [PDF]

				C. Peichel, B Prabhakaran, and T. Vogt The mouse Ulnaless mutation deregulates posterior HoxD gene expression and alters appendicular patterning Development, January 9, 1997; 124(18): 3481 - 3492. [Abstract] [PDF]

				R Koster, R Stick, F Loosli, and J Wittbrodt Medaka spalt acts as a target gene of hedgehog signaling Development, January 8, 1997; 124(16): 3147 - 3156. [Abstract] [PDF]

				J Lee, K. Platt, P Censullo, and A Ruiz i Altaba Gli1 is a target of Sonic hedgehog that induces ventral neural tube development Development, January 7, 1997; 124(13): 2537 - 2552. [Abstract] [PDF]