Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor

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Ali-Rachedi, A., Varndell, I. M., Adrian, T. E., Gapp, D. A., Van Noorden, S., Bloom, S. R. and Polak, J. M (1984). Peptide YY (PYY) immunoreactivity is co-stored with glucagon-related immunoreactants in endocrine cells of the gut and pancreas. Histochemistry 80, 487-91.[Medline]

Alpert, S., Hanahan, D. and Teitelman, G (1988). Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons. Cell 53, 295-308.[Medline]

B\232ttcher, G., Sjolund, K., Ekblad, E., H\214kanson, R., Schwartz, T. W. and Sundler, F (1984). Coexistence of peptide YY and glicentin immunoreactivity in endocrine cells of the gut. Regul. Peptides 8, 261-6.[Medline]

B\232ttcher, G., Ahren, B., Lundquist, I. and Sundler, F (1989). Peptide YY: intrapancreatic localization and effects on insulin and glucagon secretion in the mouse. Pancreas 4, 282-8.[Medline]

B\232ttcher, G., Sjoberg, J., Ekman, R., H\214kanson, R. and Sundler, F (1993). Peptide YY in the mammalian pancreas: immunocytochemical localization and immunochemical characterization. Regul. Peptides 43, 115-130.[Medline]

Bradl, M., Larue, L. and Mintz, B (1991). Clonal coat color variation due to a transforming gene expressed in melanocytes of transgenic mice. Proc. Natl. Acad. Sci. USA 88, 6447-6451.[Abstract/Free Full Text]

Deltour, L., Leduque, P., Blume, N., Madsen, O., Dubois, P., Jami, J. and Bucchini, D (1993). Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo. Proc. Natl. Acad. Sci. USA 90, 527-531.[Abstract/Free Full Text]

Fiocca, R., Rindi, G., Capella, C., Grimelius, L., Polak, J. M., Schwartz, T. W., Yanaihara, N. and Solcia,E (1987). Glucagon, glicentin, proglucagon, PYY, PP and proPP-icosapeptide immunoreactivities of rectal carcinoid tumors and related non-tumor cells. Regul. Peptides 17, 9-29.[Medline]

Gittes, G., and Rutter, W (1992). Onset of cell-specific gene expression in the developing mouse pancreas. Proc. Natl. Acad. Sci. USA 89, 1128-1132.[Abstract/Free Full Text]

Greeley, G. H. Jr, Lluis, F., Gomez, G., Ishizuka, J., Holland, B. and Thompson, J. C (1988). Peptide YY antagonizes beta-adrenergic stimulated release of insulin in dogs. Am. J. Physiol 254, 513-.

Herrera, P., Huarte, J., Sanvito, F., Meda, P., Orci, L. and Vassalli, J (1991). Embryogenesis of the murine pancreas; early expression of pancreatic polypeptide gene. Development 113, 1257-1265.[Abstract]

Krasinski, S., Wheeler, M. and Leiter, A (1991). Isolation, characterization, and developmental expression of the rat peptide YY gene. Mol. Endocrinol 5, 433-440.[Abstract]

Leduque, P., Paulin, C. and Dubois, P (1983). Immunocytochemical evidence for a substance related to the bovine pancreatic polypeptide-peptide YY group of peptides in the human fetal gastrointestinal tract. Regul. Peptides 6, 219-230.[Medline]

Lee, Y. C., Asa, S. L. and Drucker, D. J (1992). Glucagon gene 5flanking sequences direct expression of Simian Virus 40 large T antigen to the intestine, producing carcinoma of the large bowel in transgenic mice. J. Biol. Chem 267, 10705-10708.[Abstract/Free Full Text]

Lozano, M. T., Garcia, A. A., Abad, M. E. and Agulleiro, B (1991). Pancreatic endocrine cells in sea bass (Dicentrarchus labrax L.) I. Immunocytochemical characterization of glucagon-and PP-related peptides. Gen. Comp. Endocrinol 81, 187-97.[Medline]

Mahon, K. A., Chepelinsky, A. B., Khillan, J. S., Overbeek, P. A.,Piatigorsky, J. and Westphal, J (1987). Oncogenesis of the lens in transgenic mice. Science 235, 1622-1628.[Abstract/Free Full Text]

Nilsson, O., Bilchik, A. J., Goldenring, J. R., Ballantyne, G. H., Adrian, T. E. and Modlin I. M (1991). Distribution and immunocytochemical colocalization of peptide YY and enteroglucagon in endocrine cells of the rabbit colon. Endocrinology 129, 139-48.[Abstract]

Rall, L. B., Pictet, R. L., Williams, R. H. and Rutter, W. J (1973). Early differentiation of glucagon-producing cells in embryonic pancreas: a possible developmental role for glucagon. Proc. Natl. Acad. Sci. USA 70, 3478-3482.[Abstract/Free Full Text]

Rindi, G., Grant, S. G. N., Yiangou, Y., Ghatei, M. A., Bloom, S. R., Bautch, V. L., Solcia, E. and Polak, J. M. ( (1990). Development of neuroendocrine tumors in the GI tract of transgenic mice- heterogeneity of hormone expression. Am. J. Pathol 136, 1349-1363.[Abstract]

Rombout, J., van der Grinten, C., Peeze Binkhorst, F., Taverne-Thiele, J. and Schooneveld, H (1986). Immunocytochemical identification and localization of peptide hormones in the gastro-entero-pancreatic (GEP)endocrine system of the mouse and a stomachless fish, Barbus conchonius. Histochemistry 84, 471-483.[Medline]

Sundler, F., H\214kanson, R. and Larsson, L. I (1977). Ontogeny of rat pancreatic polypeptide (PP) cells. Cell. Tissue Res 178, 303-306.[Medline]

Sundler, F., B\232ttcher, G., H\214kanson, R. and Schwartz, T. W (1984). Immunocytochemical localization of the icosapeptide fragment of the PP precursor: a marker for \324true' PP cells?. Regul. Peptides 8, 217-224.[Medline]

Tatemoto, K (1982). Neuropeptide Y: Complete amino acid sequence of the brain peptide. Proc. Natl. Acad. Sci. USA 79, 5485-5489.[Abstract/Free Full Text]

Teitelman, G., Alpert, S., Polak, J. M., Martinez, A. and Hanahan, D (1993). Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development 118, 1031-1039.[Abstract]

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				P. Gregor, Y. Feng, L. B. DeCarr, L. J. Cornfield, and M. L. McCaleb Molecular Characterization of a Second Mouse Pancreatic Polypeptide Receptor and Its Inactivated Human Homologue J. Biol. Chem., November 1, 1996; 271(44): 27776 - 27781. [Abstract] [Full Text] [PDF]

				J. Jensen, P. Serup, C. Karlsen, T. F. Nielsen, and O. D. Madsen mRNA Profiling of Rat Islet Tumors Reveals Nkx 6.1as a beta -Cell-specific Homeodomain Transcription Factor J. Biol. Chem., August 2, 1996; 271(31): 18749 - 18758. [Abstract] [Full Text] [PDF]

				B. Upchurch, B. Fung, G Rindi, A Ronco, and A. Leiter Peptide YY expression is an early event in colonic endocrine cell differentiation: evidence from normal and transgenic mice Development, January 4, 1996; 122(4): 1157 - 1163. [Abstract] [PDF]