The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Diaz-Benjumea, F. J.
	Articles by Hafen, E.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Diaz-Benjumea, F. J.
	Articles by Hafen, E.

Ambrosio, L., Mahowald, A. P. and Perrimon, N (1989). Requirement of the Drosophila raf homologue for torso function. Nature 342, 288-291.[Medline]

Aroian, R. V., Koga, M., Mendel, J. E., Ohshima, Y. and Sternberg, P. W (1990). The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature 348, 693-699.[Medline]

Baker, N. E. and Rubin, G. M (1989). Effect on eye development of dominant mutations in Drosophila homologue of the EGF receptor. Nature 340, 150-153.[Medline]

Baker, N. E. and Rubin, G. M (1992). Ellipse mutations in the Drosophila homologue of the EGF receptor affect pattern formation, cell division, and cell death in eye imaginal discs. Dev. Biol 150, 381-396.[Medline]

Banerjee, U., Renfranz, P. J., Pollock, J. A. and Benzer, S (1987). Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eye. Cell 49, 281-291.[Medline]

Basler, K. and Hafen, E (1988). Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain. Cell 54, 299-312.[Medline]

Beitel, G. J., Clark, S. G. and Horvitz, R (1990). Caenorhabditis elegansras gene let-60 acts as a switch in the pathway of vulval induction. Nature 348, 503-509.[Medline]

Bishop III, J. G. and Corces, V (1988). Expression of an activated ras gene causes developmental abnormalities in transgenic Drosophilamelanogaster. Genes Dev 2, 567-577.[Abstract/Free Full Text]

Bowtell, D., Simon, M. A. and Rubin, G. M (1988). Nucleotide sequence and structure of the sevenless gene of Drosophila melanogaster. Genes Dev 2, 620-634.[Abstract/Free Full Text]

Carthew, R. W. and Rubin, G. M (1990). seven in absentia , a gene required for specification of R7 cell fate in the Drosophila eye. Cell 63, 561-577.[Medline]

Casanova, J. and Struhl, G (1989). Localized surface activity of torso , a receptor tyrosine kinase, specifies terminal body pattern in Drosophila. Genes Dev 3, 2025-2038.[Abstract/Free Full Text]

Chabot, B., Stephenson, D. A., Chapman, V. M., Besmer, P. and Bernstein, A (1988). The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 335, 88-89.[Medline]

Chao, M. V (1992). Growth factor signaling: Where is the specificity?. Cell 68, 995-997.[Medline]

Clark, S. G., Stern, M. J. and Horvitz, H. R (1992). C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains. Nature 356, 340-344.[Medline]

Clifford, R. and Schupbach, T (1992). The torpedo (DER) receptor tyrosine kinase is required at multiple times during Drosophila embryogenesis. Development 115, 853-872.[Abstract]

Clifford, R. J. and Schupbach, T (1989). Coordinately and differentially mutable activities of torpedo , the Drosophila melanogaster homolog of the vertebrate EGF receptor gene. Genetics 123, 771-787.[Abstract/Free Full Text]

Crews, C. M. and Erikson, R. L (1993). Extracellular signals and reversible protein phosphorylation: What to Mek of it all. Cell 74, 215-217.[Medline]

Diaz-Benjumea, F. J. and Garcia-Bellido, A (1990). Behaviour of cells mutant for an EGF receptor homologue of Drosophila in genetic mosaics. Proc. R. Soc. Lond. B 242, 36-44.[Medline]

Dickson, B., Sprenger, F., Morrison, D. and Hafen, E (1992). Raf functions downstream of Ras1 in the Sevenless signal transduction pathway. Nature 360, 600-603.[Medline]

Doyle, H. J. and Bishop, J. M (1993). Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the Sevenless and EGF-R pathways in Drosophila. Genes Dev 7, 633-646.[Abstract/Free Full Text]

Ferrus, A (1974). Parameters of mitotic recombination of Minute mutants of Drosophila melanogaster. Genetics 79, 589-599.

Ferrus, A. and Garcia-Bellido, A (1976). Morphogenetic mutants detected in mitotic recombination clones. Nature 260, 425-426.[Medline]

Fortini, M. E., Simon, M. A. and Rubin, G. M (1992). Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation. Nature 355, 559-561.[Medline]

Garcia-Bellido, A. and de Celis, J. F (1992). Developmental genetics of the venation pattern of Drosophila. Annu Rev Genet 26, 277-304.[Medline]

Gaul, U., Mardon, G. and Rubin, G. M (1992). A putative Ras GTPase activating protein acts as a negative regulator of signaling by the sevenless receptor tyrosine kinase. Cell 68, 1007-1019.[Medline]

Geissler, E. N., Ryan, M. A. and Housman, D. E (1988). The dominant white spotting ( W ) locus of the mouse encodes the c-kit proto-oncogene. Cell 55, 185-192.[Medline]

Hafen, E., Basler, K., Edstroem, J. E. and Rubin, G. M (1987). sevenless, a cell-specific homeotic gene of Drosophila , encodes a putative transmembrane receptor with a tyrosine kinase domain. Science 236, 55-63.[Abstract/Free Full Text]

Han, M., Golden, A., Han, Y. and Sternberg, P. W (1993). C. elegans lin-45 raf gene participates in let-60 ras -stimulated vulval differentiation. Nature 363, 133-140.[Medline]

Han, M. and Sternberg, P. W (1990). let-60 , a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein. Cell 63, 921-931.[Medline]

Hilliker, A. J (1976). Genetic analysis of the centromeric heterochromatin of chromosome 2 of Drosophilamelanogaster : deficiency mapping of EMS-induced lethal complementation groups. Genetics 83, 765-782.[Abstract/Free Full Text]

Howe, L. R., Leevers, S. J., Gomez, N., Nakielny, S., Cohen, P. and Marshall, C. J (1992). Activation of the MAP kinase pathway by the protein kinase raf. Cell 71, 335-342.[Medline]

Klingler, M., Erdelyi, M., Szabad, J. and Nusslein-Volhard, C (1988). Function of torso in determining the terminal anlagen of the Drosophila embryo. Nature 335, 275-277.[Medline]

Kremer, N. E., D, A. G., Thomas, S. M., DeMarco, M., Brugge, J. S. and Halegoua, S (1991). Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions. J. Cell Biol 115, 809-819.[Abstract/Free Full Text]

Lu, X., Chou, T. B., Williams, N. G., Roberts, T. and Perrimon, N (1993). Control of cell fate determination by p21ras/Ras1 , an essential component of torso signaling in Drosophila. Genes Dev 7, 621-632.[Abstract/Free Full Text]

Marais, R., Wynne, J. and Treisman, R (1993). The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73, 381-393.[Medline]

Melnick, M. B., Perkins, L. A., Lee, M., Ambrosio, L. and Perrimon, N (1993). Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase. Development 118, 127-138.[Abstract]

Mulcahy, L. S., Smith, M. R. and Stacey, D. W (1985). Requirement for ras proto-oncogene function during serum-stimulated growth of NIH3T3 cells. Nature 313, 241-243.[Medline]

Olivier, J. P., Raabe, T., Henkemeyer, M., Dickson, B., Mbamalu, G., Margolis, B., Schlessinger, J., Hafen, E. and Pawson, T (1993). A Drosophila SH2-SH3 adaptor protein implicated in coupling the Sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell 73, 179-191.[Medline]

Phillips, R. G. and Whittle, J. R. S (1993). wingless expression mediates determination of peripheral nervous system elements in late stages of Drosophila wing disc development. Development 118, 427-438.[Abstract]

Posakony, L. G., Raftery, L. A. and Gelbart, W. M (1990). Wing formation in Drosophila melanogaster requires decapentaplegic gene function along the anterior-posterior compartment boundary. Mech. Dev 33, 69-82.[Medline]

Price, J. V., Clifford, R. J. and Schupbach, T (1989). The maternal ventralizing locus torpedo is allelic to faint little ball , an embryonic lethal, and encodes the Drosophila EGF receptor homolog. Cell 56, 1085-1092.[Medline]

Rogge, R. D., Karlovich, C. A. and Banerjee, U (1991). Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases. Cell 64, 39-48.[Medline]

Schejter, E. D. and Shilo, B. Z (1989). The Drosophila EGF receptor homolog (DER) gene is allelic to faint little ball , a locus essential for embryonic development. Cell 56, 1093-1104.[Medline]

Schupbach, T (1987). Germ line and soma cooperate during oogenesis to establish the dorsoventral pattern of egg shell and embryo in Drosophila melanogaster. Cell 49, 699-707.[Medline]

Segal, D. and Gelbart, W. M (1985). shortvein , a new component of the decapentaplegic gene complex in Drosophila melanogaster. Genetics 109, 119-143.[Abstract/Free Full Text]

Simon, M. A., Bowtell, D., Dodson, G. S., Laverty, T. R. and Rubin, G. M (1991). Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell 67, 701-716.[Medline]

Simon, M. A., Dodson, G. S. and Rubin, G. M (1993). An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro. Cell 73, 169-177.[Medline]

Sprenger, F., Stevens, L. M. and Nusslein-Volhard, C (1989). The Drosophila gene torso encodes a putative receptor tyrosine kinase. Nature 338, 478-483.[Medline]

Sturtevant, M. A., Roark, M. and Bier, E (1993). The Drosophilarhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. Genes Dev 7, 961-973.[Abstract/Free Full Text]

Thomas, S. M., DeMarco, M., D'Arcangelo, G., Halegoua, S. and Brugge, J. S (1992). Ras is essential for nerve growth factor-and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Cell 68, 1031-1040.[Medline]

Traverse, S., Gomez, N., Paterson, H., Marshall, C. and Cohen, P (1992). Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem. J 288, 351-355.

Wood, K. W., Sarnecki, C., Roberts, T. M. and Blenis, J (1992). ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell 68, 1041-1050.[Medline]

Xu, T. and Rubin, G. M (1993). Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117, 1223-1237.[Abstract]

This article has been cited by other articles:

A. Martin-Pena, A. Acebes, J.-R. Rodriguez, A. Sorribes, G. G. de Polavieja, P. Fernandez-Funez, and A. Ferrus
Age-Independent Synaptogenesis by Phosphoinositide 3 Kinase
J. Neurosci., October 4, 2006; 26(40): 10199 - 10208.
[Abstract] [Full Text] [PDF]

C. M. A. Coelho, B. Kolevski, C. D. Walker, I. Lavagi, T. Shaw, A. Ebert, S. J. Leevers, and S. J. Marygold
A Genetic Screen for Dominant Modifiers of a Small-Wing Phenotype in Drosophila melanogaster Identifies Proteins Involved in Splicing and Translation
Genetics, October 1, 2005; 171(2): 597 - 614.
[Abstract] [Full Text] [PDF]

M. Cully, A. Elia, S.-H. Ong, V. Stambolic, T. Pawson, M.-S. Tsao, and T. W. Mak
grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice
PNAS, October 26, 2004; 101(43): 15358 - 15363.
[Abstract] [Full Text] [PDF]

M. Angulo, M. Corominas, and F. Serras
Activation and repression activities of ash2 in Drosophila wing imaginal discs
Development, October 15, 2004; 131(20): 4943 - 4953.
[Abstract] [Full Text] [PDF]

H. Yoshida, E. Kwon, F. Hirose, K. Otsuki, M. Yamada, and M. Yamaguchi
DREF is required for EGFR signalling during Drosophila wing vein development
Genes Cells, October 1, 2004; 9(10): 935 - 944.
[Abstract] [Full Text] [PDF]

M. Kim, G.-H. Cha, S. Kim, J. H. Lee, J. Park, H. Koh, K.-Y. Choi, and J. Chung
MKP-3 Has Essential Roles as a Negative Regulator of the Ras/Mitogen-Activated Protein Kinase Pathway during Drosophila Development
Mol. Cell. Biol., January 15, 2004; 24(2): 573 - 583.
[Abstract] [Full Text] [PDF]

L. K. MacDougall, M. E. Gagou, S. J. Leevers, E. Hafen, and M. D. Waterfield
Targeted Expression of the Class II Phosphoinositide 3-Kinase in Drosophila melanogaster Reveals Lipid Kinase-Dependent Effects on Patterning and Interactions with Receptor Signaling Pathways
Mol. Cell. Biol., January 15, 2004; 24(2): 796 - 808.
[Abstract] [Full Text] [PDF]

M. Morey, M. Corominas, and F. Serras
DIAP1 suppresses ROS-induced apoptosis caused by impairment of the selD/sps1 homolog in Drosophila
J. Cell Sci., November 15, 2003; 116(22): 4597 - 4604.
[Abstract] [Full Text] [PDF]

S. K. Pallavi and L. S. Shashidhara
Egfr/Ras pathway mediates interactions between peripodial and disc proper cells in Drosophila wing discs
Development, October 15, 2003; 130(20): 4931 - 4941.
[Abstract] [Full Text] [PDF]

S. Szuplewski, B. Kottler, and R. Terracol
The Drosophila bZIP transcription factor Vrille is involved in hair and cell growth
Development, August 15, 2003; 130(16): 3651 - 3662.
[Abstract] [Full Text] [PDF]

H. Araujo, E. Negreiros, and E. Bier
Integrins modulate Sog activity in the Drosophila wing
Development, August 15, 2003; 130(16): 3851 - 3864.
[Abstract] [Full Text] [PDF]

H. V. Lin, D. B. Doroquez, S. Cho, F. Chen, I. Rebay, and K. M. Cadigan
Splits ends is a tissue/promoter specific regulator of Wingless signaling
Development, July 15, 2003; 130(14): 3125 - 3135.
[Abstract] [Full Text] [PDF]

R. Mankidy, J. Hastings, and J. R. Thackeray
Distinct Phospholipase C-{gamma}-Dependent Signaling Pathways in the Drosophila Eye and Wing Are Revealed by a New small wing Allele
Genetics, June 1, 2003; 164(2): 553 - 563.
[Abstract] [Full Text] [PDF]

D. del Alamo, J. Terriente, and F. J. Diaz-Benjumea
Spitz/EGFr signalling via the Ras/MAPK pathway mediates the induction of bract cells in Drosophila legs
Development, March 6, 2003; 129(8): 1975 - 1982.
[Abstract] [Full Text] [PDF]

M. Zecca and G. Struhl
Subdivision of the Drosophila wing imaginal disc by EGFR-mediated signaling
Development, March 5, 2003; 129(6): 1357 - 1368.
[Abstract] [Full Text] [PDF]

M. Zecca and G. Struhl
Control of growth and patterning of the Drosophila wing imaginal disc by EGFR-mediated signaling
Development, March 5, 2003; 129(6): 1369 - 1376.
[Abstract] [Full Text] [PDF]

F. Roch, G. Jimenez, and J. Casanova
EGFR signalling inhibits Capicua-dependent repression during specification of Drosophila wing veins
Development, March 4, 2003; 129(4): 993 - 1002.
[Abstract] [Full Text] [PDF]

S. E. Baker, J. A. Lorenzen, S. W. Miller, T. A. Bunch, A. L. Jannuzi, M. H. Ginsberg, L. A. Perkins, and D. L. Brower
Genetic Interaction Between Integrins and moleskin, a Gene Encoding a Drosophila Homolog of Importin-7
Genetics, September 1, 2002; 162(1): 285 - 296.
[Abstract] [Full Text] [PDF]

D. A. Prober and B. A. Edgar
Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing
Genes & Dev., September 1, 2002; 16(17): 2286 - 2299.
[Abstract] [Full Text] [PDF]

H.-B. Kwon, S.-H. Kim, S.-E. Kim, I.-H. Jang, Y. Ahn, W.-J. Lee, and K.-Y. Choi
Drosophila Extracellular Signal-regulated Kinase Involves the Insulin-mediated Proliferation of Schneider Cells
J. Biol. Chem., April 19, 2002; 277(17): 14853 - 14858.
[Abstract] [Full Text] [PDF]

A. Guichard, S. Srinivasan, G. Zimm, and E. Bier
A screen for dominant mutations applied to components in the Drosophila EGF-R pathway
PNAS, March 19, 2002; 99(6): 3752 - 3757.
[Abstract] [Full Text] [PDF]

A. L. Knox and N. H. Brown
Rap1 GTPase Regulation of Adherens Junction Positioning and Cell Adhesion
Science, February 15, 2002; 295(5558): 1285 - 1288.
[Abstract] [Full Text] [PDF]

K. Radke, K. Johnson, R. Guo, A. Davidson, and L. Ambrosio
Drosophila-Raf Acts to Elaborate Dorsoventral Pattern in the Ectoderm of Developing Embryos
Genetics, November 1, 2001; 159(3): 1031 - 1044.
[Abstract] [Full Text] [PDF]

S. Talapatra and C. B. Thompson
Growth Factor Signaling in Cell Survival: Implications for Cancer Treatment
J. Pharmacol. Exp. Ther., September 1, 2001; 298(3): 873 - 878.
[Abstract] [Full Text]

L. Ciapponi, D. B. Jackson, M. Mlodzik, and D. Bohmann
Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites
Genes & Dev., June 15, 2001; 15(12): 1540 - 1553.
[Abstract] [Full Text] [PDF]

K Halfar, C Rommel, H Stocker, and E Hafen
Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity
Development, January 5, 2001; 128(9): 1687 - 1696.
[Abstract] [PDF]

F Wittwer, A van der Straten, K Keleman, B. Dickson, and E Hafen
Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth
Development, January 3, 2001; 128(5): 791 - 800.
[Abstract] [PDF]

J Culi, E Martin-Blanco, and J Modolell
The EGF receptor and N signalling pathways act antagonistically in Drosophila mesothorax bristle patterning
Development, January 1, 2001; 128(2): 299 - 308.
[Abstract] [PDF]

B. Yun, K. Lee, R. Farka, C. Hitte, and L. Rabinow
The LAMMER Protein Kinase Encoded by the Doa Locus of Drosophila Is Required in Both Somatic and Germline Cells and Is Expressed as Both Nuclear and Cytoplasmic Isoforms Throughout Development
Genetics, October 1, 2000; 156(2): 749 - 761.
[Abstract] [Full Text]

W. Li, E. Noll, and N. Perrimon
Identification of Autosomal Regions Involved in Drosophila Raf Function
Genetics, October 1, 2000; 156(2): 763 - 774.
[Abstract] [Full Text]

S Sotillos and S Campuzano
DRacGAP, a novel Drosophila gene, inhibits EGFR/Ras signalling in the developing imaginal wing disc
Development, January 12, 2000; 127(24): 5427 - 5438.
[Abstract] [PDF]

A Baonza, J. de Celis, and A Garcia-Bellido
Relationships between extramacrochaetae and Notch signalling in Drosophila wing development
Development, January 6, 2000; 127(11): 2383 - 2393.
[Abstract] [PDF]

C Pazman, C. Mayes, M Fanto, S. Haynes, and M Mlodzik
Rasputin, the Drosophila homologue of the RasGAP SH3 binding protein, functions in ras- and Rho-mediated signaling
Development, January 4, 2000; 127(8): 1715 - 1725.
[Abstract] [PDF]

P. Feldmann, E. N. Eicher, S. J. Leevers, E. Hafen, and D. A. Hughes
Control of Growth and Differentiation by Drosophila RasGAP, a Homolog of p120 Ras-GTPase-Activating Protein
Mol. Cell. Biol., March 1, 1999; 19(3): 1928 - 1937.
[Abstract] [Full Text] [PDF]

Q. Zhang, Q. Zheng, and X. Lu
A Genetic Screen for Modifiers of Drosophila Src42A Identifies Mutations in Egfr, rolled and a Novel Signaling Gene
Genetics, February 1, 1999; 151(2): 697 - 711.
[Abstract] [Full Text]

H Matakatsu, R Tadokoro, S Gamo, and S Hayashi
Repression of the wing vein development in Drosophila by the nuclear matrix protein plexus
Development, January 12, 1999; 126(23): 5207 - 5216.
[Abstract] [PDF]

E Martin-Blanco, F Roch, E Noll, A Baonza, J. Duffy, and N Perrimon
A temporal switch in DER signaling controls the specification and differentiation of veins and interveins in the Drosophila wing
Development, January 12, 1999; 126(24): 5739 - 5747.
[Abstract] [PDF]

A Guichard, B Biehs, M. Sturtevant, L Wickline, J Chacko, K Howard, and E Bier
rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development
Development, January 6, 1999; 126(12): 2663 - 2676.
[Abstract] [PDF]

R Nagaraj, A. Pickup, R Howes, K Moses, M Freeman, and U Banerjee
Role of the EGF receptor pathway in growth and patterning of the Drosophila wing through the regulation of vestigial
Development, January 2, 1999; 126(5): 975 - 985.
[Abstract] [PDF]

E. Martín-Blanco, A. Gampel, J. Ring, K. Virdee, N. Kirov, A. M. Tolkovsky, and A. Martinez-Arias
puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in�Drosophila
Genes & Dev., February 15, 1998; 12(4): 557 - 570.
[Abstract] [Full Text]

J. Thackeray, P. Gaines, P Ebert, and J. Carlson
small wing encodes a phospholipase C-(gamma) that acts as a negative regulator of R7 development in Drosophila
Development, January 12, 1998; 125(24): 5033 - 5042.
[Abstract] [PDF]

A. Michelson, S Gisselbrecht, E Buff, and J. Skeath
Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila
Development, January 11, 1998; 125(22): 4379 - 4389.
[Abstract] [PDF]

J. Kumar, M Tio, F Hsiung, S Akopyan, L Gabay, R Seger, B. Shilo, and K Moses
Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation
Development, January 10, 1998; 125(19): 3875 - 3885.
[Abstract] [PDF]

F Roch, A Baonza, E Martin-Blanco, and A Garcia-Bellido
Genetic interactions and cell behaviour in blistered mutants during proliferation and differentiation of the Drosophila wing
Development, January 5, 1998; 125(10): 1823 - 1832.
[Abstract] [PDF]

F. Karim and G. Rubin
Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues
Development, January 1, 1998; 125(1): 1 - 9.
[Abstract] [PDF]

Q. Li, I. K. Hariharan, F. Chen, Y. Huang, and J. A. Fischer
Genetic interactions with Rap1 and Ras1 reveal a second function for the Fat facets deubiquitinating enzyme in Drosophila�eye�development
PNAS, November 11, 1997; 94(23): 12515 - 12520.
[Abstract] [Full Text] [PDF]

J. de Celis, S Bray, and A Garcia-Bellido
Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing
Development, January 5, 1997; 124(10): 1919 - 1928.
[Abstract] [PDF]

J. de Celis
Expression and function of decapentaplegic and thick veins during the differentiation of the veins in the Drosophila wing
Development, January 3, 1997; 124(5): 1007 - 1018.
[Abstract] [PDF]

M Freeman
Cell determination strategies in the Drosophila eye
Development, January 1, 1997; 124(2): 261 - 270.
[Abstract] [PDF]

S Gisselbrecht, J B Skeath, C Q Doe, and A M Michelson
heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo.
Genes & Dev., December 1, 1996; 10(23): 3003 - 3017.
[Abstract] [PDF]

N. Oellers and E. Hafen
Biochemical Characterization of RolledSem, an Activated Form of Drosophila Mitogen-activated Protein Kinase
J. Biol. Chem., October 4, 1996; 271(40): 24939 - 24944.
[Abstract] [Full Text] [PDF]

R Burke and K Basler
Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing
Development, July 1, 1996; 122(7): 2261 - 2269.
[Abstract] [PDF]

L Gabay, H Scholz, M Golembo, A Klaes, B. Shilo, and C Klambt
EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm
Development, January 11, 1996; 122(11): 3355 - 3362.
[Abstract] [PDF]

M Golembo, E Raz, and B. Shilo
The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm
Development, January 11, 1996; 122(11): 3363 - 3370.
[Abstract] [PDF]

				C. M. A. Coelho, B. Kolevski, C. D. Walker, I. Lavagi, T. Shaw, A. Ebert, S. J. Leevers, and S. J. Marygold A Genetic Screen for Dominant Modifiers of a Small-Wing Phenotype in Drosophila melanogaster Identifies Proteins Involved in Splicing and Translation Genetics, October 1, 2005; 171(2): 597 - 614. [Abstract] [Full Text] [PDF]

				M. Cully, A. Elia, S.-H. Ong, V. Stambolic, T. Pawson, M.-S. Tsao, and T. W. Mak grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice PNAS, October 26, 2004; 101(43): 15358 - 15363. [Abstract] [Full Text] [PDF]

				M. Angulo, M. Corominas, and F. Serras Activation and repression activities of ash2 in Drosophila wing imaginal discs Development, October 15, 2004; 131(20): 4943 - 4953. [Abstract] [Full Text] [PDF]

				H. Yoshida, E. Kwon, F. Hirose, K. Otsuki, M. Yamada, and M. Yamaguchi DREF is required for EGFR signalling during Drosophila wing vein development Genes Cells, October 1, 2004; 9(10): 935 - 944. [Abstract] [Full Text] [PDF]

				M. Kim, G.-H. Cha, S. Kim, J. H. Lee, J. Park, H. Koh, K.-Y. Choi, and J. Chung MKP-3 Has Essential Roles as a Negative Regulator of the Ras/Mitogen-Activated Protein Kinase Pathway during Drosophila Development Mol. Cell. Biol., January 15, 2004; 24(2): 573 - 583. [Abstract] [Full Text] [PDF]

				L. K. MacDougall, M. E. Gagou, S. J. Leevers, E. Hafen, and M. D. Waterfield Targeted Expression of the Class II Phosphoinositide 3-Kinase in Drosophila melanogaster Reveals Lipid Kinase-Dependent Effects on Patterning and Interactions with Receptor Signaling Pathways Mol. Cell. Biol., January 15, 2004; 24(2): 796 - 808. [Abstract] [Full Text] [PDF]

				M. Morey, M. Corominas, and F. Serras DIAP1 suppresses ROS-induced apoptosis caused by impairment of the selD/sps1 homolog in Drosophila J. Cell Sci., November 15, 2003; 116(22): 4597 - 4604. [Abstract] [Full Text] [PDF]

				S. K. Pallavi and L. S. Shashidhara Egfr/Ras pathway mediates interactions between peripodial and disc proper cells in Drosophila wing discs Development, October 15, 2003; 130(20): 4931 - 4941. [Abstract] [Full Text] [PDF]

				S. Szuplewski, B. Kottler, and R. Terracol The Drosophila bZIP transcription factor Vrille is involved in hair and cell growth Development, August 15, 2003; 130(16): 3651 - 3662. [Abstract] [Full Text] [PDF]

				H. Araujo, E. Negreiros, and E. Bier Integrins modulate Sog activity in the Drosophila wing Development, August 15, 2003; 130(16): 3851 - 3864. [Abstract] [Full Text] [PDF]

				H. V. Lin, D. B. Doroquez, S. Cho, F. Chen, I. Rebay, and K. M. Cadigan Splits ends is a tissue/promoter specific regulator of Wingless signaling Development, July 15, 2003; 130(14): 3125 - 3135. [Abstract] [Full Text] [PDF]

				R. Mankidy, J. Hastings, and J. R. Thackeray Distinct Phospholipase C-{gamma}-Dependent Signaling Pathways in the Drosophila Eye and Wing Are Revealed by a New small wing Allele Genetics, June 1, 2003; 164(2): 553 - 563. [Abstract] [Full Text] [PDF]

				D. del Alamo, J. Terriente, and F. J. Diaz-Benjumea Spitz/EGFr signalling via the Ras/MAPK pathway mediates the induction of bract cells in Drosophila legs Development, March 6, 2003; 129(8): 1975 - 1982. [Abstract] [Full Text] [PDF]

				M. Zecca and G. Struhl Subdivision of the Drosophila wing imaginal disc by EGFR-mediated signaling Development, March 5, 2003; 129(6): 1357 - 1368. [Abstract] [Full Text] [PDF]

				M. Zecca and G. Struhl Control of growth and patterning of the Drosophila wing imaginal disc by EGFR-mediated signaling Development, March 5, 2003; 129(6): 1369 - 1376. [Abstract] [Full Text] [PDF]

				F. Roch, G. Jimenez, and J. Casanova EGFR signalling inhibits Capicua-dependent repression during specification of Drosophila wing veins Development, March 4, 2003; 129(4): 993 - 1002. [Abstract] [Full Text] [PDF]

				S. E. Baker, J. A. Lorenzen, S. W. Miller, T. A. Bunch, A. L. Jannuzi, M. H. Ginsberg, L. A. Perkins, and D. L. Brower Genetic Interaction Between Integrins and moleskin, a Gene Encoding a Drosophila Homolog of Importin-7 Genetics, September 1, 2002; 162(1): 285 - 296. [Abstract] [Full Text] [PDF]

				D. A. Prober and B. A. Edgar Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing Genes & Dev., September 1, 2002; 16(17): 2286 - 2299. [Abstract] [Full Text] [PDF]

				H.-B. Kwon, S.-H. Kim, S.-E. Kim, I.-H. Jang, Y. Ahn, W.-J. Lee, and K.-Y. Choi Drosophila Extracellular Signal-regulated Kinase Involves the Insulin-mediated Proliferation of Schneider Cells J. Biol. Chem., April 19, 2002; 277(17): 14853 - 14858. [Abstract] [Full Text] [PDF]

				A. Guichard, S. Srinivasan, G. Zimm, and E. Bier A screen for dominant mutations applied to components in the Drosophila EGF-R pathway PNAS, March 19, 2002; 99(6): 3752 - 3757. [Abstract] [Full Text] [PDF]

				A. L. Knox and N. H. Brown Rap1 GTPase Regulation of Adherens Junction Positioning and Cell Adhesion Science, February 15, 2002; 295(5558): 1285 - 1288. [Abstract] [Full Text] [PDF]

				K. Radke, K. Johnson, R. Guo, A. Davidson, and L. Ambrosio Drosophila-Raf Acts to Elaborate Dorsoventral Pattern in the Ectoderm of Developing Embryos Genetics, November 1, 2001; 159(3): 1031 - 1044. [Abstract] [Full Text] [PDF]

				S. Talapatra and C. B. Thompson Growth Factor Signaling in Cell Survival: Implications for Cancer Treatment J. Pharmacol. Exp. Ther., September 1, 2001; 298(3): 873 - 878. [Abstract] [Full Text]

				L. Ciapponi, D. B. Jackson, M. Mlodzik, and D. Bohmann Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites Genes & Dev., June 15, 2001; 15(12): 1540 - 1553. [Abstract] [Full Text] [PDF]

				K Halfar, C Rommel, H Stocker, and E Hafen Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity Development, January 5, 2001; 128(9): 1687 - 1696. [Abstract] [PDF]

				F Wittwer, A van der Straten, K Keleman, B. Dickson, and E Hafen Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth Development, January 3, 2001; 128(5): 791 - 800. [Abstract] [PDF]

				J Culi, E Martin-Blanco, and J Modolell The EGF receptor and N signalling pathways act antagonistically in Drosophila mesothorax bristle patterning Development, January 1, 2001; 128(2): 299 - 308. [Abstract] [PDF]

				B. Yun, K. Lee, R. Farka, C. Hitte, and L. Rabinow The LAMMER Protein Kinase Encoded by the Doa Locus of Drosophila Is Required in Both Somatic and Germline Cells and Is Expressed as Both Nuclear and Cytoplasmic Isoforms Throughout Development Genetics, October 1, 2000; 156(2): 749 - 761. [Abstract] [Full Text]

				W. Li, E. Noll, and N. Perrimon Identification of Autosomal Regions Involved in Drosophila Raf Function Genetics, October 1, 2000; 156(2): 763 - 774. [Abstract] [Full Text]

				S Sotillos and S Campuzano DRacGAP, a novel Drosophila gene, inhibits EGFR/Ras signalling in the developing imaginal wing disc Development, January 12, 2000; 127(24): 5427 - 5438. [Abstract] [PDF]