Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Capdevila, J.
	Articles by Guerrero, I.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Capdevila, J.
	Articles by Guerrero, I.


Social Bookmarking

	What's this?

Baker, N. E (1987). Molecular cloning of sequences from wingless , a segmentpolarity gene in Drosophila : the spatial distribution of a transcript in embryos. EMBO J 6, 1765-1773.[Medline]

Baker, N. E (1988). Embryonic and imaginal requirements for wg , a segment polarity gene in Drosophila. Dev. Biol 125, 96-108.[Medline]

Bate, M., Rushton, E. and Currie, D. A (1991). Cells with persistent twist expression are the embryonic precursors of adult muscles in Drosophila. Development 113, 79-89.[Abstract]

Bejsovec, A. and Mart\222nez Arias, A (1991). Roles of wingless in patterning the larval epidermis of Drosophila. Development 113, 471-485.[Abstract]

Bejsovec, A. and Wieschaus, E (1993). Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos. Development 119, 501-517.[Abstract]

Bogaert, T., Brown, N. and Wilcox, M (1987). The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle attachments. Cell 51, 929-940.[Medline]

Chen, M. S., Obar, R. A., Schroeder, C. C., Austin, T. W., Poodry, C. A., Wadsworth, S. C. and Vallee, R. B (1991). Multiple forms of dynamin are encoded by shibire , a Drosophila gene involved in endocytosis. Nature 351, 583-586.[Medline]

DiNardo, S., Sher, E., Heemskerk-Jongens, J., Kasis, J. A. and O'Farrell, P. H (1988). Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis. Nature 332, 604-609.[Medline]

Dougan, S. and DiNardo, S (1992). Drosophila wingless generates cell type diversity among engrailed expressing cells. Nature 360, 347-349.[Medline]

Gallyas, F., G\232res, T. and Merchentaler, I (1982). High-grade intensification of the end product of the diaminobenzidine reaction for peroxidase histochemistry. J. Histochem. Cytochem 30, 183-184.[Abstract]

Gonz\207lez, F., Swales, L., Bejsovec, A., Skaer, H. and Mart\222nez Arias, A (1991). Secretion and movement of wingless protein in the epidermis of the Drosophila embryo. Mech. Dev 35, 43-54.[Medline]

Grigliatti, T. A., Hall, L., Rosenbluth, R. and Suzuki, D. T (1973). Temperature-sensitive mutations in Drosophila melanogaster . XIV. A selection of immobile adults. Molec. Gen. Genet 120, 107-114.[Medline]

Hidalgo, A (1991). Interactions between segment polarity genes and the generation of the segmental pattern in Drosophila. Mech. of Dev 35, 77-87.[Medline]

Hirano, S., Ui, K., Miyake, T., Uemura, T. and Takeichi, M (1991). Drosophila PS integrins recognize vertebrate vitronectin and function as cell-substratum adhesion receptors in vitro. Development 113, 1007-1016.[Abstract]

Hooper, J. E. and Scott, M. P (1989). The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell 59, 751-765.[Medline]

Hortsch, M. and Goodman, C. S (1991). Cell and substrate adhesion molecules in Drosophila. Annu. Rev. Cell Biol 7, 505-557.

Ingham, P. W (1991). Segment polarity genes and cell patterning within the Drosophila body segment. Curr. Opinion in Gen. and Dev 1, 261-267.[Medline]

Ingham, P. W., Taylor, A. M. and Nakano, Y (1991). Role of the Drosophila patched gene in positional signalling. Nature 353, 184-187.[Medline]

Ingham, P. A. and Mart\222nez Arias, A (1992). Boundaries and fields in early embryos. Cell 68, 221-235.[Medline]

Ingham, P. W. and Hidalgo, A (1993). Regulation of wingless transcription in the Drosophila embryo. Development 117, 283-291.[Abstract/Free Full Text]

Kosaka, T. and Ikeda, K (1983). Reversible blockage of membrane retrieval and endocytosis in the garland cell of the temperature sensitive mutant of Drosophilamelanogaster , shibirets1. J. Cell Biol 97, 499-507.[Abstract/Free Full Text]

Laemmli, E. K (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.[Medline]

Lawrence, P. A., Johnston, P., Macdonald, P. and Struhl, G (1987). Borders of parasegments in Drosophila embryos are delimited by the fushi tarazu and genes. Nature 328, 440-442.[Medline]

Lee, J. J., von Kessler, D. P., Parks, S. and Beachy, P. A (1992). Secretionand localized transcription suggest a role in positional signaling for products of the segmentation gene hedhehog. Cell 71, 33-50.[Medline]

Leptin, M., Bogaert, T., Lehman, R. and Wilcox, M (1989). The function of PS integrins during Drosophila embryogenesis. Cell 56, 401-406.[Medline]

Macdonald, P. M. and Struhl, G (1986). A molecular gradient in early Drosophila embryos and its role in specifying the body pattern. Nature 324, 537-545.[Medline]

McCrea, P. D., Turck, C. W. and Gumbiner, B (1991). A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin. Science 254, 1359-1361.[Abstract/Free Full Text]

McMahon, A. P. and Bradley, A (1990). The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62, 1073-1085.[Medline]

McMahon, A. P., Joyner, A. L., Bradley, A. and McMahon, J. A (1992). The midbrain-hindbrain phenotype of Wnt-1/Wnt-1 mice results from stepwise deletion of engrailed expressing cells by 9.5 days postcoitum. Cell 69, 581-595.[Medline]

Magee, A. I. and Buxton, R. S (1991). Transmembrane molecular assemblies regulated by the greater cadherin family. Curr. Opinion in Cell Biol 3, 854-861.[Medline]

Mart\222nez Arias, A. and Lawrence, P. A (1985). Parasegments and compartments in the Drosophila embryo. Nature 313, 639-642.[Medline]

Mart\222nez Arias, A., Baker, N. and Ingham, P (1988). Role of the segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo. Development 103, 157-170.[Abstract]

Mitchison, T. J. and Sedat, J (1983). Localization of antigenic determinants in whole Drosophila embryos. Dev. Biol 99, 261-264.[Medline]

Mohler, J. and Vani, K (1992). Molecular organization and embryonic expression of the hedhehog gene involved in cell-cell communication in segmental patterning of Drosophila. Development 115, 957-971.[Abstract]

Morata, G. and Lawrence, P. A (1975). Control of compartment development by the engrailed gene in Drosophila. Nature 255, 614-617.[Medline]

Morata, G. and Lawrence, P. A (1977). The development of wingless , a homeotic mutation of Drosophila. Dev. Biol 56, 227-240.[Medline]

Nakano, Y. I., Guerrero, I., Hidalgo, A., Taylor, A., Whittle, J. and Ingham, P (1989). A protein with several possible membrane spanning domains encoded by the Drosophila segment polarity gene patched. Nature 341, 508-513.[Medline]

Narita, K., Tsuruhara, T., Koenig, J. H. and Ikeda, K (1989). Membrane pinch-off and reinsertion observed in living cells of Drosophila. J. Cell. Physiol 141, 383-391.[Medline]

Nordermeer, J., Johnston, P., Rijsewijk, F., Nusse, R. and Lawrence, P. A (1992). The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo. Development 116, 711-719.[Abstract]

Nusslein-Volhard, C. and Wieschaus, E (1980). Mutations affecting segment number and polarity in Drosophila. Nature 287, 795-801.[Medline]

Olson, D. J., Christian, J. L. and Moon, R. T (1991). Effect of Wnt-1 and related proteins on gap junctional communication in Xenopus embryos. Science 252, 1173-1176.[Free Full Text]

Patel, N. H., Schafer, B., Goodman, C. S. and Holmgren, R (1989). The role of segment polarity genes during Drosophila neurogenesis. Genes Dev 3, 890-904.[Abstract/Free Full Text]

Peifer, M (1993). The product of the Drosophila segment polarity gene armadillo is part of a multi-protein complex resembling the vertebrate adherens junction. J. Cell Sci 105, 993-1000.[Abstract]

Peifer, M. and Bejsovec, A (1992). Knowing your neighbors: Cell interactions determine intrasegmental patterning in Drosophila. Trends Genet 8, 243-248.

Peifer, M. and Wieschaus, E (1990). The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin. Cell 63, 1167-1178.[Medline]

Peifer, M., McCrea, P. D., Green, K. J., Wieschaus, E. and Gumbiner, B. M (1992). The vertebrate adhesive junction proteins-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties. J. Cell Biol 118, 681-691.[Abstract/Free Full Text]

Peifer, M., Orsulic, S., Sweeton, D. and Wieschaus, E (1993). A role for the Drosophila segment polarity gene armadillo in cell adhesion and cytoskeletal integrity during oogenesis. Development 118, 1191-1207.[Abstract]

Peifer, M., Rauskolb, C., Williams, M., Riggleman, B. and Wieschaus, E (1991). The segment polarity gene armadillo interacts with the wingless signaling pathway in both embryonic and adult pattern formation. Development 111, 1029-1043.[Abstract/Free Full Text]

Riggleman, B., Schedl, P. and Wieschaus, E (1990). Spatial expression of the Drosophila segment polarity gene armadillo is post-transcriptionally regulated by wingless. Cell 63, 549-560.[Medline]

Rijsewijk, F., Schuermann, M., Wagenaar, E., Parren, P., Weigel, D. and Nusse, R (1987). The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell 50, 647-657.

Rothman., J. H., Raymond, C. K., Gilbert, T., O'Hara, P. J. and Stevens, T. H (1990). A putative GTP binding protein homologous to interferon-inducible Mx proteins performs an essential function in yeast protein sorting. Cell 61, 1063-1074.[Medline]

Ruther, U. and Muller-Hill, B (1983). Easy identification of cDNA clones. EMBO J 2, 1791-1794.[Medline]

Sampedro, J. and Guerrero, I (1991). Unrestricted expression of the Drosophila gene patched allows a normal segment polarity. Nature 353, 187-190.[Medline]

Sampedro, J., Johnston, P. and Lawrence, P. A (1993). A role for wingless in the segmental gradient of Drosophila ?. Development 117, 677-687.[Abstract]

Smith, D. B. and Johnson, K. S (1988). Single-step purification of polypeptides expressed in E. coli as fusions with glutathione S-transferase. Gene 67, 31-40.[Medline]

Tabata, T., Eaton, S. and Kornberg, T. B (1992). The Drosophilahedhehog gene is expressed specifically in posterior compartment cells and it is a target of engrailed regulation. Genes Dev 6, 2635-2645.[Abstract/Free Full Text]

Tashiro, S., Michiue, T., Higashijima, S., Zenno, S., Ishimaru, S., Takahashi, F., Orihara, M., Kojima, T. and Saigo, K (1993). Structure and expression of hedhehog , a Drosophila segment-polarity gene required for cell-cell communication. Gene 124, 183-189.[Medline]

Thisse, B., Stoetzel, C., El Messal, M. and Perrin-Schmitt, F (1987). Genes of the Drosophila maternal dorsal group control the specific expression of the zygotic gene twist in presumptive mesodermal cells. Genes Dev 1, 709-715.[Abstract/Free Full Text]

Thomas, K. R. and Capecchi, M. R (1990). Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346, 847-850.[Medline]

Tsukita, S., Tsukita, S., Nagafuchi, A. and Yonemura, S (1992). Molecular linkage between cadherins and actin filaments in cell-cell adherens junctions. Curr. Op. Cell Biol 4, 834-839.[Medline]

van den Heuvel, M., Nusse, R., Johnston, P. and Lawrence, P. A (1989). Distribution of the wingless gene product in Drosophila embryos: a protein involved in cell-cell communication. Cell 59, 739-749.[Medline]

van der Blieck, A. M. and Meyerowitz, E. M (1991). Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic. Nature 351, 411-414.[Medline]

Vincent, J.-P. and O'Farrell, P. H (1992). The state of engrailed expression is not clonally transmitted during early Drosophila development. Cell 68, 923-931.[Medline]

Wieschaus, E. and Riggleman, B (1987). Autonomous requirements for the segment polarity gene armadillo during Drosophila embryogenesis. Cell 49, 177-184.[Medline]

Woods, D. F. and Bryant, P. J (1992). Genetic control of cell interactions in developing Drosophila epithelia. Annu. Rev. Genet._Fb_26 , 305-350.While this paper was undergoing revision, another paper by Taylor, A. M. et al. (1993) appeared, describing the distribu-tion of ptc protein in Drosophila embryos (. Mech. Dev 42, 89-96.

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

Technorati

Twitter What's this?

This article has been cited by other articles:

S. Kawamura, K. Hervold, F.-A. Ramirez-Weber, and T. B. Kornberg
Two Patched Protein Subtypes and a Conserved Domain of Group I Proteins That Regulates Turnover
J. Biol. Chem., November 7, 2008; 283(45): 30964 - 30969.
[Abstract] [Full Text] [PDF]

T. Bollenbach, P. Pantazis, A. Kicheva, C. Bokel, M. Gonzalez-Gaitan, and F. Julicher
Precision of the Dpp gradient
Development, March 15, 2008; 135(6): 1137 - 1146.
[Abstract] [Full Text] [PDF]

D. J. Casso, S. Liu, D. D. Iwaki, S. K. Ogden, and T. B. Kornberg
A Screen for Modifiers of Hedgehog Signaling in Drosophila melanogaster Identifies swm and mts
Genetics, March 1, 2008; 178(3): 1399 - 1413.
[Abstract] [Full Text] [PDF]

X. Lu, S. Liu, and T. B. Kornberg
The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover
Genes & Dev., September 15, 2006; 20(18): 2539 - 2551.
[Abstract] [Full Text] [PDF]

E. Nieuwenhuis, J. Motoyama, P. C. Barnfield, Y. Yoshikawa, X. Zhang, R. Mo, M. A. Crackower, and C.-c. Hui
Mice with a Targeted Mutation of Patched2 Are Viable but Develop Alopecia and Epidermal Hyperplasia.
Mol. Cell. Biol., September 1, 2006; 26(17): 6609 - 6622.
[Abstract] [Full Text] [PDF]

F. Wendler, X. Franch-Marro, and J.-P. Vincent
How does cholesterol affect the way Hedgehog works?
Development, August 15, 2006; 133(16): 3055 - 3061.
[Abstract] [Full Text] [PDF]

A. Callejo, C. Torroja, L. Quijada, and I. Guerrero
Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix
Development, February 1, 2006; 133(3): 471 - 483.
[Abstract] [Full Text] [PDF]

S. K. Pallavi and L. S. Shashidhara
Signaling interactions between squamous and columnar epithelia of the Drosophila wing disc
J. Cell Sci., August 1, 2005; 118(15): 3363 - 3370.
[Abstract] [Full Text] [PDF]

C. Torroja, N. Gorfinkiel, and I. Guerrero
Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction
Development, May 15, 2004; 131(10): 2395 - 2408.
[Abstract] [Full Text] [PDF]

J. E. Hooper
Smoothened translates Hedgehog levels into distinct responses
Development, September 1, 2003; 130(17): 3951 - 3963.
[Abstract] [Full Text] [PDF]

R. A. McCarthy and W. S. Argraves
Megalin and the neurodevelopmental biology of sonic hedgehog and retinol
J. Cell Sci., March 15, 2003; 116(6): 955 - 960.
[Abstract] [Full Text] [PDF]

J. D. Lee, K. Amanai, A. Shearn, and J. E. Treisman
The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms
Development, March 14, 2003; 129(24): 5697 - 5706.
[Abstract] [Full Text] [PDF]

C. Hosono, K. Takaira, R. Matsuda, and K. Saigo
Functional subdivision of trunk visceral mesoderm parasegments in Drosophila is required for gut and trachea development
Development, February 1, 2003; 130(3): 439 - 449.
[Abstract] [Full Text] [PDF]

J. K. Chen, J. Taipale, M. K. Cooper, and P. A. Beachy
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
Genes & Dev., November 1, 2002; 16(21): 2743 - 2748.
[Abstract] [Full Text] [PDF]

E. S. Seto, H. J. Bellen, and T. E. Lloyd
When cell biology meets development: endocytic regulation of signaling pathways
Genes & Dev., June 1, 2002; 16(11): 1314 - 1336.
[Full Text] [PDF]

S. Roy and P. W. Ingham
Hedgehogs tryst with the cell cycle
J. Cell Sci., January 12, 2002; 115(23): 4393 - 4397.
[Abstract] [Full Text] [PDF]

K. Williams, P Rayhorn, G Chi-Rosso, E. Garber, K. Strauch, G. Horan, J. Reilly, D. Baker, F. Taylor, V Koteliansky, et al.
Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity
J. Cell Sci., January 12, 1999; 112(23): 4405 - 4414.
[Abstract] [PDF]

U Gritzan, V Hatini, and S DiNardo
Mutual antagonism between signals secreted by adjacent wingless and engrailed cells leads to specification of complementary regions of the Drosophila parasegment
Development, January 9, 1999; 126(18): 4107 - 4115.
[Abstract] [PDF]

M. K. Cooper, J. A. Porter, K. E. Young, and P. A. Beachy
Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
Science, June 5, 1998; 280(5369): 1603 - 1607.
[Abstract] [Full Text]

S Bellusci, Y Furuta, M. Rush, R Henderson, G Winnier, and B. Hogan
Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis
Development, January 1, 1997; 124(1): 53 - 63.
[Abstract] [PDF]

L V Goodrich, R L Johnson, L Milenkovic, J A McMahon, and M P Scott
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.
Genes & Dev., February 1, 1996; 10(3): 301 - 312.
[Abstract] [PDF]

R. Johnson, J. Grenier, and M. Scott
patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets
Development, January 12, 1995; 121(12): 4161 - 4170.
[Abstract] [PDF]

I Guillen, J. Mullor, J Capdevila, E Sanchez-Herrero, G Morata, and I Guerrero
The function of engrailed and the specification of Drosophila wing pattern
Development, January 10, 1995; 121(10): 3447 - 3456.
[Abstract] [PDF]

C Ma and K Moses
Wingless and patched are negative regulators of the morphogenetic furrow and can affect tissue polarity in the developing Drosophila compound eye
Development, January 8, 1995; 121(8): 2279 - 2289.
[Abstract] [PDF]

M Peifer
The two faces of hedgehog
Science, December 2, 1994; 266(5190): 1492 - 1493.
[PDF]

H. E. Karpen, J. T. Bukowski, T. Hughes, J.-P. Gratton, W. C. Sessa, and M. R. Gailani
The Sonic Hedgehog Receptor Patched Associates with Caveolin-1 in Cholesterol-rich Microdomains of the Plasma Membrane
J. Biol. Chem., June 1, 2001; 276(22): 19503 - 19511.
[Abstract] [Full Text] [PDF]

J. P. Incardona, J. H. Lee, C. P. Robertson, K. Enga, R. P. Kapur, and H. Roelink
Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1
PNAS, October 24, 2000; 97(22): 12044 - 12049.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Capdevila, J.

Articles by Guerrero, I.

Search for Related Content

PubMed

PubMed Citation

Articles by Capdevila, J.

Articles by Guerrero, I.

Social Bookmarking

What's this?

				T. Bollenbach, P. Pantazis, A. Kicheva, C. Bokel, M. Gonzalez-Gaitan, and F. Julicher Precision of the Dpp gradient Development, March 15, 2008; 135(6): 1137 - 1146. [Abstract] [Full Text] [PDF]

				D. J. Casso, S. Liu, D. D. Iwaki, S. K. Ogden, and T. B. Kornberg A Screen for Modifiers of Hedgehog Signaling in Drosophila melanogaster Identifies swm and mts Genetics, March 1, 2008; 178(3): 1399 - 1413. [Abstract] [Full Text] [PDF]

				X. Lu, S. Liu, and T. B. Kornberg The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover Genes & Dev., September 15, 2006; 20(18): 2539 - 2551. [Abstract] [Full Text] [PDF]

				E. Nieuwenhuis, J. Motoyama, P. C. Barnfield, Y. Yoshikawa, X. Zhang, R. Mo, M. A. Crackower, and C.-c. Hui Mice with a Targeted Mutation of Patched2 Are Viable but Develop Alopecia and Epidermal Hyperplasia. Mol. Cell. Biol., September 1, 2006; 26(17): 6609 - 6622. [Abstract] [Full Text] [PDF]

				F. Wendler, X. Franch-Marro, and J.-P. Vincent How does cholesterol affect the way Hedgehog works? Development, August 15, 2006; 133(16): 3055 - 3061. [Abstract] [Full Text] [PDF]

				A. Callejo, C. Torroja, L. Quijada, and I. Guerrero Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix Development, February 1, 2006; 133(3): 471 - 483. [Abstract] [Full Text] [PDF]

				S. K. Pallavi and L. S. Shashidhara Signaling interactions between squamous and columnar epithelia of the Drosophila wing disc J. Cell Sci., August 1, 2005; 118(15): 3363 - 3370. [Abstract] [Full Text] [PDF]

				C. Torroja, N. Gorfinkiel, and I. Guerrero Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction Development, May 15, 2004; 131(10): 2395 - 2408. [Abstract] [Full Text] [PDF]

				J. E. Hooper Smoothened translates Hedgehog levels into distinct responses Development, September 1, 2003; 130(17): 3951 - 3963. [Abstract] [Full Text] [PDF]

				R. A. McCarthy and W. S. Argraves Megalin and the neurodevelopmental biology of sonic hedgehog and retinol J. Cell Sci., March 15, 2003; 116(6): 955 - 960. [Abstract] [Full Text] [PDF]

				J. D. Lee, K. Amanai, A. Shearn, and J. E. Treisman The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms Development, March 14, 2003; 129(24): 5697 - 5706. [Abstract] [Full Text] [PDF]

				C. Hosono, K. Takaira, R. Matsuda, and K. Saigo Functional subdivision of trunk visceral mesoderm parasegments in Drosophila is required for gut and trachea development Development, February 1, 2003; 130(3): 439 - 449. [Abstract] [Full Text] [PDF]

				J. K. Chen, J. Taipale, M. K. Cooper, and P. A. Beachy Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened Genes & Dev., November 1, 2002; 16(21): 2743 - 2748. [Abstract] [Full Text] [PDF]

				E. S. Seto, H. J. Bellen, and T. E. Lloyd When cell biology meets development: endocytic regulation of signaling pathways Genes & Dev., June 1, 2002; 16(11): 1314 - 1336. [Full Text] [PDF]

				S. Roy and P. W. Ingham Hedgehogs tryst with the cell cycle J. Cell Sci., January 12, 2002; 115(23): 4393 - 4397. [Abstract] [Full Text] [PDF]

				K. Williams, P Rayhorn, G Chi-Rosso, E. Garber, K. Strauch, G. Horan, J. Reilly, D. Baker, F. Taylor, V Koteliansky, et al. Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity J. Cell Sci., January 12, 1999; 112(23): 4405 - 4414. [Abstract] [PDF]

				U Gritzan, V Hatini, and S DiNardo Mutual antagonism between signals secreted by adjacent wingless and engrailed cells leads to specification of complementary regions of the Drosophila parasegment Development, January 9, 1999; 126(18): 4107 - 4115. [Abstract] [PDF]

				M. K. Cooper, J. A. Porter, K. E. Young, and P. A. Beachy *Teratogen-Mediated Inhibition of Target Tissue Response to Shh* Signaling** Science, June 5, 1998; 280(5369): 1603 - 1607. [Abstract] [Full Text]

				S Bellusci, Y Furuta, M. Rush, R Henderson, G Winnier, and B. Hogan Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis Development, January 1, 1997; 124(1): 53 - 63. [Abstract] [PDF]

				L V Goodrich, R L Johnson, L Milenkovic, J A McMahon, and M P Scott Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes & Dev., February 1, 1996; 10(3): 301 - 312. [Abstract] [PDF]

				R. Johnson, J. Grenier, and M. Scott patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets Development, January 12, 1995; 121(12): 4161 - 4170. [Abstract] [PDF]

				I Guillen, J. Mullor, J Capdevila, E Sanchez-Herrero, G Morata, and I Guerrero The function of engrailed and the specification of Drosophila wing pattern Development, January 10, 1995; 121(10): 3447 - 3456. [Abstract] [PDF]

				C Ma and K Moses Wingless and patched are negative regulators of the morphogenetic furrow and can affect tissue polarity in the developing Drosophila compound eye Development, January 8, 1995; 121(8): 2279 - 2289. [Abstract] [PDF]

				M Peifer The two faces of hedgehog Science, December 2, 1994; 266(5190): 1492 - 1493. [PDF]

				H. E. Karpen, J. T. Bukowski, T. Hughes, J.-P. Gratton, W. C. Sessa, and M. R. Gailani The Sonic Hedgehog Receptor Patched Associates with Caveolin-1 in Cholesterol-rich Microdomains of the Plasma Membrane J. Biol. Chem., June 1, 2001; 276(22): 19503 - 19511. [Abstract] [Full Text] [PDF]

				J. P. Incardona, J. H. Lee, C. P. Robertson, K. Enga, R. P. Kapur, and H. Roelink Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1 PNAS, October 24, 2000; 97(22): 12044 - 12049. [Abstract] [Full Text] [PDF]