An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells

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Artavanis-Tsakonas, S. and Simpson, P (1991). Choosing a cell fate: a view from the Notch locus. Trends Genet 7, 403-8.[Medline]

Austin, J. and Kimble, J (1989). Transcript analysis of glp-1 and lin-12, homologous genes required for cell interactions during development of C. elegans. Cell 58, 565-571.[Medline]

Bader, D., Masaki, T. and Fischman, D (1982). Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro. J. Cell Biol 95, 763-770.[Abstract/Free Full Text]

Berg, R. W. and McBurney, M. W (1990). Cell density and cell cycle effects on retinoic acid-induced embryonal carcinoma cell differentiation. Dev. Biol 138, 123-35.[Medline]

Breeden, L. and Nasmyth, K (1987). Similarity between cell-cycle genes of budding yeast and fission yeast and the Notch gene of Drosophila. Nature 329, 651-4.[Medline]

Cagan, R. L. and Ready, D. F (1989). Notch is required for successive cell decisions in the developing Drosophila retina. Genes Dev 3, 1099-1112.[Abstract/Free Full Text]

Coffman, C., Harris, W. and Kintner, C (1990). Xotch, the Xenopus homologue of Drosophila Notch. Science 249, 1438-1441.[Abstract/Free Full Text]

Coffman, C. R., Skoglund, P., Harris, W. A. and Kintner, C. R (1993). Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos. Cell 73, 659-61.[Medline]

Corbin, V., Michelson, A. M., Abmayr, S. M., Neel, V., Alcamo, E., Maniatis, T. and Young, M. W (1991). A role for the Drosophila neurogenic genes in mesoderm differentiation. Cell 67, 311-323.[Medline]

Edwards, M. K. S., Harris, J. F. and McBurney, M. W (1983). Induced muscle differentiation in an embryonal carcinoma cell line. Mol. Cell. Biol 3, 2280-2286.[Abstract/Free Full Text]

Ellisen, L. W., Bird, J., West, D. C., Soreng, A. L., Reynolds, T. C., Smith, S. D. and Sklar, J (1991). TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66, 649-61.[Medline]

Evan, G. I., Lewis, G. K., Ramsay, G. and Bishop, J. M (1985). Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell. Biol 5, 3610-3616.[Abstract/Free Full Text]

Fortini, M. E., Rebay, I., Caron, L. A. and Artavanis-Tsakonas, S (1993). An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature 365, 555-557.[Medline]

Franco del Amo, F., Gendron-Maguire, M., Swiatek, P., Jenkins, N. A., Copeland, N. G. and Gridley, T (1993). Cloning, analysis, and chromosomal localization of Notch-1, a mouse homolog of Drosophila Notch. Genomics 15, 259-264.[Medline]

Franco del Amo, F., Smith, D. E., Swiatek, P. J., M., G.-M., Greenspan, R. J., McMahon, A. P. and Gridley, T (1992). Expression pattern of Motch , amouse homolog of Drosophila Notch , suggests an important role in early postimplantation mouse development. Development 115, 737-44.[Abstract]

Frederiksen, K. and McKay, R (1988). Proliferation and differentiation of rat neuroepithelial precurseor cells in vivo. J. Neurosci 8, 1144-1151.[Abstract]

Fujii, H. and Hamada, H (1993). A CNS specific POU transcription factor, Brn2, is required for establishing mammalian neural cell lineages. Neuron 11, 1197-1206.[Medline]

Gallileo, D. S., Gray, G. E., Owen, G. C., Majors, J. and Sanes, J. R (1990). Neurons and glia arise from common progenitor in chicken optic tectum: demonstration with two retroviruses and cell type specific antibodies. Proc. Nat. Acad. Sci. USA 87, 458-462.[Abstract/Free Full Text]

Greenwald, I (1985). Lin12, a nematode homeotic gene is homologous to a set of mammalian proteins that includes EGF. Cell 43, 583-90.[Medline]

Greenwald, I. and Rubin, G. M (1992). Making a difference: the role of cell-cell interactions in establishing separate identities for equivalent cells. Cell 68, 271-281.[Medline]

Hartenstein, V. and Posakony, J (1990). A dual functio of the Notch gene in Drosophila sensillum development. Dev. Biol 142, 13-30.[Medline]

Heitzler, P. and Simpson, P (1991). The choice of cell fate in the epidermis of Drosophila. Cell 64, 1083-92.[Medline]

Heitzler, P. and Simpson, P (1993). Altered epidermal growth factor-like sequences provide evidence for a role of Notch as receptor for epidermal development. Development 117, 1113-1123.[Abstract]

Hockfield, S. and McKay, R. D. G (1985). Identification of major cell classes in the developing mammalian nervous system. J. Neurosc 5, 3310-3328.[Abstract]

Hoppe, P. E. and Greenspan, R. J (1990). The Notch locus of Drosophila is required in epidermal cells for epidermal development. Development 109, 875-85.[Abstract/Free Full Text]

Jhappan, C., Gallahan, D., Stahle, C., Chu, E., Smith, G. H., Merlino, G. and Callahan, R (1992). Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev 6, 345-55.[Abstract/Free Full Text]

Jones-Villeneuve, E. M. V., McBurney, M. W., Rogers, K. A. and Kalnins, V. I (1982). Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells. J. Cell Biol 94, 253-262.[Abstract/Free Full Text]

Jones-Villeneuve, E. M. V., Rudnicki, M. A., Harris, J. F. and McBurney, M. W (1983). Retinoic acid-induced neural differentiation of embryonal carcinoma cells. Mol. Cell. Biol 3, 2271-2279.[Abstract/Free Full Text]

Kidd, S., Kelley, M. R. and Young., M. W (1986). Sequence of the Notch locus of Drosophila: relationship of the encoded protein to mamalian clotting and growth factors. Mol. Cell. Biol 6, 3094-3108.[Abstract/Free Full Text]

Kopan, R., Nye, J. S. and Weintraub, H (1994). The intracellular domain of mouse Notch : a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development_Fb_120 Kopan, R. and Weintraub, H. (1993). Mouse Notch: expression in hair follicles correlates with cell fate determination. J. Cell Biol 121, 631-641.

Kopczynski, C. C., Alton, A. K., Fechtel, K., Kooh, P. J. and Muskavitch, M. A. T (1988). Delta, a Drosophila neurogenic gene is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates. Genes Dev 2, 1723-1735.[Abstract/Free Full Text]

Lardelli, M. and Lendahl, U (1993). MotchA and MotchB-Two mouse Notc homologues coexpressed in a wide variety of tissues. Exp. Cell Res 204, 364-372.[Medline]

Lendahl, U., Zimmerman, L. B. and McKay, R. D. G (1990). CNS Stem cells express a new class of intermediate filament protein. Cell 60, 585-595.[Medline]

Levine, J. M. and Flynn, P (1986). Cell surface changes accompanying the neural differentiation of an embryonal carcinoma cell line. J. Neurosci 6, 3374-3384.[Abstract]

Lieber, T., Kidd, S., Alcamo, E., Corbin, V. and Young, M. W (1993). Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes Dev 7, 1949-1965.[Abstract/Free Full Text]

Littman, D. R., Thomas, Y., Maddon, P. J., Chess, L. and Axel, R (1985). The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes. Cell 40, 237-246.[Medline]

Lux, S. E., John, K. M. and Bennett, V (1990). Analysis of cDNA for human erythrocyte andyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins. Nature 344, 36-42.[Medline]

McBurney, M. W., Reuhl, K. R., Ally, A. I., Naisipuri, S., Bell, J. C. and Craig, J (1988). Differentiation and maturation of embryonal carcinoma derived neurons in cell culture. J. Neurosci 8, 1063-73.[Abstract]

Mullen, R. J., Buck, C. R. and Smith, A. M (1992). NeuN, a neuronal specific nuclear protein in invertebrates. Development 116, 201-211.[Abstract]

Munro, S. and Pelham, H. R. B (1986). An hsp70-like protein in the ER: identity with the 78kd glucose regulated protein and immunoglobin heavy chain binding protein. Cell 46, 291-300.[Medline]

Oudega, M., Arani, E. and Thomeer, R. T. W. M (1992). Transient expression of stage specific embryonic antigen (CD15) in the developing dorsal rat spinal cord. Histochem. J 24, 869-977.[Medline]

Poulson, D. F (1940). The effects of certain X-chromosome deficiencies on the embryonic development of Drosophila melanogaster. J. Exp. Zool 83, 271-325.

Reaume, A. G., Conlon, R. A., Zirngibl, R., Yamaguchi, T. P. and Rossant, J (1992). Expression analysis of a Notch homologue in the mouse embryo. Dev. Biol 154, 377-387.[Medline]

Rebay, I., Fehon, R. G. and Artavanis-Tsakonas, S (1993). Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell 74, 319-329.[Medline]

Robbins, J., Blondel, B. J., Gallahan, D. and Callahan, R (1992). Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells. J. Virol 66, 2594-9.[Abstract/Free Full Text]

Roehl, H. and Kimble, J (1993). Control of cell fate in C. elegans by a GLP-1 peptide consisting primarily of ankyrin repeats. Nature 364, 632-4.[Medline]

Shellenbarger, D. L. and Mohler, J. D (1978). Temperature sensitive periods and autonomy of pleiotropc effects of I (1)Nts1, a conditional lethal Notch in Drosophila. Dev. Biol 62, 432-446.[Medline]

Solter, D. and Knowles, B. B (1978). Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1). Proc. Nat. Acad. Sci. USA 75, 5565-5569.[Abstract/Free Full Text]

Struhl, G., Fitzgerald, K. and Greenwald, I (1993). Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo. Cell 74, 331-345.[Medline]

Swiatek, P. J., Lindsell, C. E., Franco del Amo, F., Weinmaster, G. and Gridley, T (1994). Notch1 is essential for postimplantation development in mice. Genes Dev 8, 707-719.[Abstract/Free Full Text]

Temple, S (1989). Division and differentiation of isolated CNS blast cells in microculture. Nature 340, 471-473.[Medline]

Turner, D. L. and Cepko, C (1987). A common progenitor for neurons and glia persists in rat retina late in development. Nature 328, 131-6.[Medline]

Vaessin, H., Bremer, K. A., Knust, E. and Campos-Ortega, J. A (1987). The neurogenic gene Delta of D. melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats. EMBO J 6, 3431-3440.[Medline]

Weinmaster, G., Roberts, V. J. and Lemke, G (1991). A homolog of Drosophila Notch expressed during mammalian development. Development 113, 199-205.[Abstract]

Weinmaster, G., Roberts, V. J. and Lemke, G (1992). Notch2 : a second mammalian Notch gene. Development 116, 931-41.[Abstract]

Wharton, K. A., Yedvobnick, B., Finnerty, V. G. and Artavanis-Tsakonas, S (1985). Nucleotide sequence from the neurogenic locus Notch inplies a gene product that shares homology with proteins containing EGF-like repeats. Cell 43, 567-581.[Medline]

Wigler, M., Sweet, R., Sim, G. K., Wold, B., Lacy, E., Maniatis, T., Silverstein, S. and Axel, R (1979). Transformation of mammalian cells with genes from procaryotes and eukaryotes. Cell 16, 777-785.[Medline]

Yamada, T., Placzek, M., Tanaka, H., Dodd, J. and Jessell, T. M (1991). Control of cell pattern in the developing nervous system: polarizing activity of the floor plate and notochord. Cell 64, 635-47.[Medline]

Yochem, J. and Greenwald, I (1989). glp-1 and lin-12, genes implicated in distinct cell-cell interactions in C. elegans, encode similar transmembrane proteins. Cell 58, 553-63.[Medline]

Yochem, J., Weston, K. and Greenwald, I (1988). The C. eleganslin12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch. Nature 335, 547-550.[Medline]

Zinn, K., DiMaio, D. and Maniatis, T (1983). Identification of two distinct regulatory regions adjacent ot the human beta-interferon gene. Cell 34, 865-879.[Medline]

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Physiol Rev, July 1, 1998; 78(3): 783 - 809.
[Abstract] [Full Text] [PDF]

F. Oswald, S. Liptay, G. Adler, and R. M. Schmid
NF-kappa B2 Is a Putative Target Gene of Activated Notch-1 via RBP-Jkappa
Mol. Cell. Biol., April 1, 1998; 18(4): 2077 - 2088.
[Abstract] [Full Text]

A. Bigas, D. I.�K. Martin, and L. A. Milner
Notch1 and Notch2 Inhibit Myeloid Differentiation in Response to Different Cytokines
Mol. Cell. Biol., April 1, 1998; 18(4): 2324 - 2333.
[Abstract] [Full Text]

B Appel and J. Eisen
Regulation of neuronal specification in the zebrafish spinal cord by Delta function
Development, January 2, 1998; 125(3): 371 - 380.
[Abstract] [PDF]

C. Garces, M. J. Ruiz-Hidalgo, J. F. de Mora, C. Park, L. Miele, J. Goldstein, E. Bonvini, A. Porras, and J. Laborda
Notch-1 Controls the Expression of Fatty Acid-activated Transcription Factors and Is Required for Adipogenesis
J. Biol. Chem., November 21, 1997; 272(47): 29729 - 29734.
[Abstract] [Full Text] [PDF]

				M. Hiratochi, H. Nagase, Y. Kuramochi, C.-S. Koh, T. Ohkawara, and K. Nakayama The Delta intracellular domain mediates TGF-{beta}/Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway Nucleic Acids Res., February 16, 2007; 35(3): 912 - 922. [Abstract] [Full Text] [PDF]

				M. Okochi, A. Fukumori, J. Jiang, N. Itoh, R. Kimura, H. Steiner, C. Haass, S. Tagami, and M. Takeda Secretion of the Notch-1 Abeta-like Peptide during Notch Signaling J. Biol. Chem., March 24, 2006; 281(12): 7890 - 7898. [Abstract] [Full Text] [PDF]

				V. Deregowski, E. Gazzerro, L. Priest, S. Rydziel, and E. Canalis Notch 1 Overexpression Inhibits Osteoblastogenesis by Suppressing Wnt/beta-Catenin but Not Bone Morphogenetic Protein Signaling J. Biol. Chem., March 10, 2006; 281(10): 6203 - 6210. [Abstract] [Full Text] [PDF]

				C. Hu, A. Dievart, M. Lupien, E. Calvo, G. Tremblay, and P. Jolicoeur Overexpression of Activated Murine Notch1 and Notch3 in Transgenic Mice Blocks Mammary Gland Development and Induces Mammary Tumors Am. J. Pathol., March 1, 2006; 168(3): 973 - 990. [Abstract] [Full Text] [PDF]

				M. Wines-Samuelson and J. Shen Presenilins in the Developing, Adult, and Aging Cerebral Cortex Neuroscientist, October 1, 2005; 11(5): 441 - 451. [Abstract] [PDF]

				T Haritunians, T Chow, R P J De Lange, J T Nichols, D Ghavimi, N Dorrani, D M St Clair, G Weinmaster, and C Schanen Functional analysis of a recurrent missense mutation in Notch3 in CADASIL J. Neurol. Neurosurg. Psychiatry, September 1, 2005; 76(9): 1242 - 1248. [Abstract] [Full Text] [PDF]

				D. F. Fischer, R. van Dijk, J. A. Sluijs, S. M. Nair, M. Racchi, C. N. Levelt, F. W. van Leeuwen, and E. M. Hol Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP FASEB J, September 1, 2005; 19(11): 1451 - 1458. [Abstract] [Full Text] [PDF]

				P. Hayward, K. Brennan, P. Sanders, T. Balayo, R. DasGupta, N. Perrimon, and A. M. Arias Notch modulates Wnt signalling by associating with Armadillo/{beta}-catenin and regulating its transcriptional activity Development, April 15, 2005; 132(8): 1819 - 1830. [Abstract] [Full Text] [PDF]

				K.-i. Mizutani and T. Saito Progenitors resume generating neurons after temporary inhibition of neurogenesis by Notch activation in the mammalian cerebral cortex Development, March 15, 2005; 132(6): 1295 - 1304. [Abstract] [Full Text] [PDF]

				K. Yoon, S. Nery, M. L. Rutlin, F. Radtke, G. Fishell, and N. Gaiano Fibroblast Growth Factor Receptor Signaling Promotes Radial Glial Identity and Interacts with Notch1 Signaling in Telencephalic Progenitors J. Neurosci., October 27, 2004; 24(43): 9497 - 9506. [Abstract] [Full Text] [PDF]

				M. Sciaudone, E. Gazzerro, L. Priest, A. M. Delany, and E. Canalis Notch 1 Impairs Osteoblastic Cell Differentiation Endocrinology, December 1, 2003; 144(12): 5631 - 5639. [Abstract] [Full Text] [PDF]

				L. M. Johansen, C. D. Deppmann, K. D. Erickson, W. F. Coffin III, T. M. Thornton, S. E. Humphrey, J. M. Martin, and E. J. Taparowsky EBNA2 and Activated Notch Induce Expression of BATF J. Virol., May 15, 2003; 77(10): 6029 - 6040. [Abstract] [Full Text] [PDF]

				S. Shi and P. Stanley Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways PNAS, April 29, 2003; 100(9): 5234 - 5239. [Abstract] [Full Text] [PDF]

				L. Grandbarbe, J. Bouissac, M. Rand, M. Hrabe de Angelis, S. Artavanis-Tsakonas, and E. Mohier Delta-Notch signaling controls the generation of neurons/glia from neural stem cells in a stepwise process Development, April 1, 2003; 130(7): 1391 - 1402. [Abstract] [Full Text] [PDF]

				K. Sakamoto, S. Yamaguchi, R. Ando, A. Miyawaki, Y. Kabasawa, M. Takagi, C. L. Li, B. Perbal, and K.-i. Katsube The Nephroblastoma Overexpressed Gene (NOV/ccn3) Protein Associates with Notch1 Extracellular Domain and Inhibits Myoblast Differentiation via Notch Signaling Pathway J. Biol. Chem., August 9, 2002; 277(33): 29399 - 29405. [Abstract] [Full Text] [PDF]

				S. Jeffries, D. J. Robbins, and A. J. Capobianco Characterization of a High-Molecular-Weight Notch Complex in the Nucleus of Notchic-Transformed RKE Cells and in a Human T-Cell Leukemia Cell Line Mol. Cell. Biol., June 1, 2002; 22(11): 3927 - 3941. [Abstract] [Full Text] [PDF]

				S. Hitoshi, T. Alexson, V. Tropepe, D. Donoviel, A. J. Elia, J. S. Nye, R. A. Conlon, T. W. Mak, A. Bernstein, and D. van der Kooy Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells Genes & Dev., April 1, 2002; 16(7): 846 - 858. [Abstract] [Full Text] [PDF]

				S. Stier, T. Cheng, D. Dombkowski, N. Carlesso, and D. T. Scadden Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome Blood, April 1, 2002; 99(7): 2369 - 2378. [Abstract] [Full Text] [PDF]

				B. E. Berechid, M. Kitzmann, D. R. Foltz, A. H. Roach, D. Seiffert, L. A. Thompson, R. E. Olson, A. Bernstein, D. B. Donoviel, and J. S. Nye Identification and Characterization of Presenilin-independent Notch Signaling J. Biol. Chem., March 1, 2002; 277(10): 8154 - 8165. [Abstract] [Full Text] [PDF]

				S.-i. Yamamoto, M. Nagao, M. Sugimori, H. Kosako, H. Nakatomi, N. Yamamoto, H. Takebayashi, Y.-i. Nabeshima, T. Kitamura, G. Weinmaster, et al. Transcription Factor Expression and Notch-Dependent Regulation of Neural Progenitors in the Adult Rat Spinal Cord J. Neurosci., December 15, 2001; 21(24): 9814 - 9823. [Abstract] [Full Text] [PDF]

				K. Kumano, S. Chiba, K. Shimizu, T. Yamagata, N. Hosoya, T. Saito, T. Takahashi, Y. Hamada, and H. Hirai Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression Blood, December 1, 2001; 98(12): 3283 - 3289. [Abstract] [Full Text] [PDF]

				B. Vollrath, J. Pudney, S. Asa, P. Leder, and K. Fitzgerald Isolation of a Murine Homologue of the Drosophila neuralized Gene, a Gene Required for Axonemal Integrity in Spermatozoa and Terminal Maturation of the Mammary Gland Mol. Cell. Biol., November 1, 2001; 21(21): 7481 - 7494. [Abstract] [Full Text] [PDF]

				B. Vollrath, K. J. Fitzgerald, and P. Leder A Murine Homologue of the Drosophila brainiac Gene Shows Homology to Glycosyltransferases and Is Required for Preimplantation Development of the Mouse Mol. Cell. Biol., August 15, 2001; 21(16): 5688 - 5697. [Abstract] [Full Text] [PDF]

				J. Wang, L. Shelly, L. Miele, R. Boykins, M. A. Norcross, and E. Guan Human Notch-1 Inhibits NF-{{kappa}}B Activity in the Nucleus Through a Direct Interaction Involving a Novel Domain J. Immunol., July 1, 2001; 167(1): 289 - 295. [Abstract] [Full Text] [PDF]

				S. Tani, H. Kurooka, T. Aoki, N. Hashimoto, and T. Honjo The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription Nucleic Acids Res., March 15, 2001; 29(6): 1373 - 1380. [Abstract] [Full Text] [PDF]

				C. Chambers, Y Peng, H Nguyen, N Gaiano, G Fishell, and J. Nye Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors Development, January 3, 2001; 128(5): 689 - 702. [Abstract] [PDF]

				K. Shimizu, S. Chiba, N. Hosoya, K. Kumano, T. Saito, M. Kurokawa, Y. Kanda, Y. Hamada, and H. Hirai Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2 Mol. Cell. Biol., September 15, 2000; 20(18): 6913 - 6922. [Abstract] [Full Text]

				S. Jeffries and A. J. Capobianco Neoplastic Transformation by Notch Requires Nuclear Localization Mol. Cell. Biol., June 1, 2000; 20(11): 3928 - 3941. [Abstract] [Full Text]

				R. Y. L. Tsai and R. D. G. McKay Cell Contact Regulates Fate Choice by Cortical Stem Cells J. Neurosci., May 15, 2000; 20(10): 3725 - 3735. [Abstract] [Full Text] [PDF]

				L. J. Strobl, H. Höfelmayr, G. Marschall, M. Brielmeier, G. W. Bornkamm, and U. Zimber-Strobl Activated Notch1 Modulates Gene Expression in B Cells Similarly to Epstein-Barr Viral Nuclear Antigen 2 J. Virol., February 15, 2000; 74(4): 1727 - 1735. [Abstract] [Full Text]