Developing inner ear sensory neurons require TrkB and TrkC receptors for innervation of their peripheral targets

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Avila, M. A., Varela-Nieto, I., Romero, G., Mato, J. M. Giraldez, F., Van De Water, T. R. and Represa, J (1993). Brain-derived neurotrophic factor and neurotrophin-3 support the survival and neuritogenesis response of developing cochleovestibular ganglion neurons. Dev. Biol 159, 266-275.[Medline]

Barbacid, M (1994). The Trk family of neurotrophin receptors. J. Neurobiol 25, 1386-1403.[Medline]

Berkemeier, L. R., Winslow, J. W., Kaplan, D. R., Nikolics, K., Goeddel, D. V. and Rosenthal, A (1991). Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron 7, 857-866.[Medline]

Bolender, R. P (1983). Methods for decreasing the statistical variance of stereological estimates. Anatomical Record 207, 89-106.[Medline]

Davies, A. M. and Lumsden, A. G. S (1984). Relation of target encounter and neuronal death to nerve growth factor responsiveness in the mouse developing mouse trigeminal ganglion. J. Comp. Neurol 223, 124-137.[Medline]

Davies, A. M., Thoenen, H. and Barde, Y.-A (1986). The response of chicksensory neurons to brain-derived neurotrophic factor. J. Neurosci 6, 1897-1904.[Abstract]

Davies, A. M (1987). Molecular and cellular aspects of patterning sensory neurone connections in the vertebrate nervous system. Development 101, 185-208.[Free Full Text]

Davies, A. M (1994). The role of neurotrophins in the developing nervous system. J. Neurobiol 25, 1334-1348.[Medline]

Davies, A. M., Lee, K.-F. and Jaenisch, R (1994). p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins. Neuron 11, 565-574.

Dechesne, C. J., Desmandryl, G. and Dememes, D (1987). Myelination of the mouse vestibular ganglion. Acta Otolaryngol. (Stockh.) 101, 11-18.

Ernfors, P., Merlio, J.-P. and Persson, H (1992). Cells expressing mRNA for neurotrophins and their receptors during embryonic rat development. Eur. J. Neurosci 4, 1140-1158.[Medline]

Ernfors, P. Lee, K.-F. and Jaenisch, R (1994). Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature 368, 147-150.[Medline]

Ernfors, P., Lee, K.-F., Kucera, J. and Jaenisch, R (1994). Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell 77, 503-512.[Medline]

Fari\226as, I. Jones, K. R., Backus, C., Wang, X.-Y. and Reichardt, L. F (1994). Severe sensory and sympathetic deficits in mice lacking neurotrophin-3. Nature 369, 658-661.[Medline]

Ghosh, A., Carnahan, J. and Greenberg, M. E (1994). Requirement for BDNF in activity-dependent survival of cortical neurons. Science 263, 1618-1623.[Abstract/Free Full Text]

Guth, L (1969). Trophic effects of vertebrate neurons. Neurosci. Res. Prog. Bull 7, 1-73.

Hantzopoulos, P. A., Suri, C., Glass, D. J., Goldfarb, M. P. and Yancopoulos, G. D (1994). The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins. Neuron 13, 187-201.[Medline]

Ip, N. Y., Ib\207\226ez, C. F., Nye, S. H., McClain, J., Jones, P. F., Gies, D. R., Belluscio, L., LeBeau, M. M., Espinosa, R., Squinto, S. P., Persson, H. and Yancopoulos, G. D (1992). Mammalian neurotrophin-4: structure, chromosomal location, tissue distribution, and receptor specificity. Proc. Natl. Acad. Sci. USA 89, 3060-3064.[Abstract/Free Full Text]

Ip, Y. I., Stitt, T. N., Tapley, P., Klein, R., Glass, D. J., Fandl, J., Greene, L. A., Barbacid, M. and Yancopoulos, D (1993). Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. Neuron 10, 137-149.[Medline]

Jones, K. R., Fari\226as, I., Backus, C. and Reichardt, L. F (1994). Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell 76, 989-999.[Medline]

Kaplan, D. R., Martin-Zanca, D. and Parada, L. F (1991). Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product by NGF,. Nature 350, 158-160.[Medline]

Kiang, N. Y. S., Rho, J. M., Northrop, C. C., Liebermann, M. C. and Ryngo, D. R (1982). Hair cell innervation by spiral ganglion cells in adult cats. Science 217, 175-177.[Abstract/Free Full Text]

Klein, R., Conway, D., Parada, L.F., and Barbacid, M (1990). The trkB tyrosine kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell 61, 647-656.[Medline]

Klein, R., Jing, S., Nanduri, V., O'Rourke, E. and Barbacid, M (1991). The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65, 189-197.[Medline]

Klein, R., Jing, S., Nanduri, V., Jing, S., Lamballe, F., Tapley, P., Bryant, S., Cordon-Cardo, C., Jones, K. R., Reichardt, L. F. and Barbacid, M (1991). The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell 66, 395-403.[Medline]

Klein, R., Lamballe, F., Bryant, S. and Barbacid, M (1992). The trkB tyrosine kinase is a receptor for neurotrophin-4. Neuron 8, 947-956.[Medline]

Klein, R., Smeyne, R. J., Wurst, W., Long, L. K., Auerbach, B. A. Joyner, A. L. and Barbacid, M (1993). Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell 75, 113-122.[Medline]

Klein, R (1994). Role of neurotrophins in mouse neural development. FASEB J 8, 738-744.[Abstract]

Klein, R., Silos-Santiago, I. Smeyne, R. J., Lira, S. A., Brambilla, R., Bryant, S., Zhang, L., Snider, W. D. and Barbacid M (1994). Disruption of the neurotrophin-3 receptor gene trkC eliminates Ia muscle afferents and results in abnormal movements. Nature 368, 249-251.[Medline]

Laird, P. W., Zijderweld, A., Linders, K., Rudnicki, M. A., Jaenisch, R. and Berns, A (1991). Simplified mammalian DNA isolation procedure. Nucl. Acids Res 19, 4293-.[Free Full Text]

Lamballe, F., Klein, R. and Barbacid, M (1991). trkC, a new member of the trk family of tyrosine protein kinases is a receptor for neurotrophin-3. Cell 66, 967-979.[Medline]

Lefebvre, P. P., Leprince, P., Weber, T., Rigo, J.-M., Delree and Moonen, G (1990). Neuronotrophic effect of developing otic vesicle on cochleo-vestibular neurons: evidence for nerve growth factor involvement. Brain Res 507, 254-260.[Medline]

Lefebvre, P. P., Van De Water, T. R., Represa, J., Liu, W., Bernd, P., Modlin, S., Moonen, G. and Mayer, M. B (1991). Temporal pattern of nerve growth factor (NGF) binding in vivo and the in vitro effects of NGF on cultures of developing auditory and vestibular neurons. Acta Otolaryngol. (Stockh.) 111, 304-311.[Medline]

Meakin, S. O. and Shooter, E. M (1992). The nerve growth factor family of receptors. Trends Neurosci 15, 323-331.[Medline]

Middlemas, D.S., Lindberg, R.A., and Hunter, T (1991). trkB , a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. Mol. Cell. Biol 11, 143-153.[Abstract/Free Full Text]

Pirvola, U., Ylikoski, J., Palgi, J., Lehtonen, E., Arum\212e, U. and Saarma, M (1992). Brain-derived neurotrophic and neurotrophin-3 mRNAs in the peripheral target fields of developing inner ear ganglia. Proc. Natl. Acad. Sci. USA 89, 9915-9919.[Abstract/Free Full Text]

Pirvola, U., Arum\212e, U., Moshynakov, M., Palgi, J., Saarma, M. and Ylikoski, J (1994). Coordinated expression and function of neurotrophins and their receptors in the rat inner ear during target innervation. Hearing Res 75, 131-144.[Medline]

Represa, J., Van De Water, T. R. and Bernd, P (1991). Temporal pattern of nerve growth factor receptor expression in developing cochlear and vestibular ganglia in quail and mouse. Anat. Embryol 184, 421-432.[Medline]

Schecterson, L. C. and Bothwell, M (1994). Neurotrophin and neurotrophin receptor mRNA expression in developing inner ear. Hearing Res 73, 92-100.[Medline]

Snider, W. D (1994). Functions of the neurotrophins during nervous system development: What the knockouts are teaching us. Cell 77, 627-638.[Medline]

Soppet, D., Escandon, E., Maragos, J., Middlemas, D. S., Reid, S. W., Blair, J., Burton, L. E., Stanton, B. R., Kaplan, D. R., Hunter, T., Nikolics, K. and Parada, L. F (1991). The neurotrophic factors brain-derived neurotrophic factor and neurotropin-3 are ligands for the trk B tyrosine kinase receptor. Cell 65, 895-903.[Medline]

Speidel, C. C (1947). Correlated studies of sense organs and nerves of the lateral line in living frog tadpoles. I. Regeneration of denervated organs. J. Comp. Neurol 87, 29-55.

Speidel, C. C (1948). Correlated studies of sense organs and nerves of the lateral line in living frog tadpoles. II. The trophic influence of specific nerve supply as revealed by prolonged observations of denervated and reinnervated organs. Am. J. Anat 82, 227-320.

Spoendlin, H (1969). Hair cell innervation in adult cats. Acta Otolaryngol. (Stockh.) 67, 239-243.[Medline]

Squinto, S. P., Stitt, T. N., Aldrich, T. H., Davis, S., Bianco, S. M., Radziejewski, C., Glass, D. J., Masiakowski, P., Firth, M. E., Valenzuela, D. M., DiStefano, P. S. and Yancopoulos, G. D (1991). trk B encodes a functional receptor for brain-derived neurotrophic factor and neuotrophin-3 but not nerve growth factor. Cell 65, 885-893.[Medline]

Tessarollo, L., Tsoulfas, P., Martin-Zanca, D., Gilbert, D. J., Jenkins, N. A., Copeland, N. G., and Parada, L. F (1993). trkC , a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. Development 118, 463-475.[Abstract]

Tsoulfas, P., Soppet, D., Escandon, E., Tessarollo, L., Mendoza, R. J., Rosenthal, A., Nikolics, K., and Parada, L. F (1993). The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotophin-3 in PC12 cells. Neuron 10, 975-990.[Medline]

Valenzuela, D., Maisonpierre, P., Glass, D., Rojas, E., Nunez, L., Kong, Y., Gies, D., Stitt, T., Ip, N., and Yancopoulos, G (1993). Alternative forms of rat trkC with different functional capabilities. Neuron 10, 963-974.[Medline]

Vazquez, E., Van De Water, T. R., Del Valle, M., Vega, J. A., Staecker, H., Giraldez, F. and Represa, J (1994). Pattern of trkB protein-like immunoreactivity in vivo and the in vitro effects of brain-derived neurotrophic factor (BDNF) on developing cochlear and vestibular neurons. Anat. Embryol 189, 157-167.[Medline]

Verdi, J. M., Birren, S. J., Iba\226ez, C. F., Persson, H., Kaplan, D. R., Benedetti, M., Chao, M. V. and Anderson, D. J (1994). p75LNGFRregulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells. Neuron 12, 733-745.[Medline]

Vogel, K. S. and Davies, A. M (1991). The duration of neurotrophic factor independence in early sensory neurons is matched to the time course of target field innervation. Neuron 7, 819-830.[Medline]

Von Bartheld, C. S., Patterson, S. L., Hener, J. G., Wheeler, E. F., Bothwell, M. and Rubel, E (1991). Expression of nerve growth factor (NGF) receptors in the developing inner ear of chicken and rat. Development 113, 455-470.[Abstract]

Wheeler, E. F., Bothwell, M., Schecterson, L. C. and Von Bartheld, C. S (1994). Expression of BDNF and NT-3 mRNA in hair cells of the organ of Corti: Quantitative analysis in developing rats. Hearing Res 73, 46-56.[Medline]

Wood, J. N. and Anderton, B. H (1981). Monoclonal antibodies to mammalian neurofilaments. Biosci. Rep 1, 263-268.[Medline]

Ylikoski, J., Pirvola, U., Moshnyakov, M., Palgi, J., Arum\212e, U. and Saarma, M (1993). Expression patterns of neurotrophin and their receptor mRNAs in the rat inner ear. Hearing Res 65, 69-78.[Medline]

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				A. Brugeaud, C. Travo, D. Dememes, M. Lenoir, J. Llorens, J.-L. Puel, and C. Chabbert Control of Hair Cell Excitability by Vestibular Primary Sensory Neurons J. Neurosci., March 28, 2007; 27(13): 3503 - 3511. [Abstract] [Full Text] [PDF]

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				T. Schimmang, J. Tan, M. Muller, U. Zimmermann, K. Rohbock, I. Kopschall, A. Limberger, L. Minichiello, and M. Knipper Lack of Bdnf and TrkB signalling in the postnatal cochlea leads to a spatial reshaping of innervation along the tonotopic axis and hearing loss Development, October 1, 2003; 130(19): 4741 - 4750. [Abstract] [Full Text] [PDF]

				K. Agerman, J. Hjerling-Leffler, M. P. Blanchard, E. Scarfone, B. Canlon, C. Nosrat, and P. Ernfors BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system development Development, April 15, 2003; 130(8): 1479 - 1491. [Abstract] [Full Text] [PDF]

				V. Coppola, J. Kucera, M. E. Palko, J. Martinez-De Velasco, W. E. Lyons, B. Fritzsch, and L. Tessarollo Dissection of NT3 functions in vivo by gene replacement strategy Development, November 1, 2001; 128(21): 4315 - 4327. [Abstract] [Full Text] [PDF]

				I. Farinas, K. R. Jones, L. Tessarollo, A. J. Vigers, E. Huang, M. Kirstein, D. C. de Caprona, V. Coppola, C. Backus, L. F. Reichardt, et al. Spatial Shaping of Cochlear Innervation by Temporally Regulated Neurotrophin Expression J. Neurosci., August 15, 2001; 21(16): 6170 - 6180. [Abstract] [Full Text] [PDF]

				E. J. Huang, W. Liu, B. Fritzsch, L. M. Bianchi, L. F. Reichardt, and M. Xiang Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons Development, July 1, 2001; 128(13): 2421 - 2432. [Abstract] [Full Text] [PDF]

				M. Liu, F. A. Pereira, S. D. Price, M.-j. Chu, C. Shope, D. Himes, R. A. Eatock, W. E. Brownell, A. Lysakowski, and M.-J. Tsai Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems Genes & Dev., November 15, 2000; 14(22): 2839 - 2854. [Abstract] [Full Text]

				K. AGERMAN, B. CANLON, M. DUAN, and P. ERNFORS Neurotrophins, NMDA Receptors, and Nitric Oxide in Development and Protection of the Auditory System Ann. N.Y. Acad. Sci., November 28, 1999; 884(1): 131 - 142. [Abstract] [Full Text] [PDF]

				S. Wyatt, G. Middleton, E. Doxakis, and A. M. Davies Selective Regulation of trkC Expression by NT3 in the Developing Peripheral Nervous System J. Neurosci., August 1, 1999; 19(15): 6559 - 6570. [Abstract] [Full Text] [PDF]

				S. I. Lentz, C. M. Knudson, S. J. Korsmeyer, and W. D. Snider Neurotrophins Support the Development of Diverse Sensory Axon Morphologies J. Neurosci., February 1, 1999; 19(3): 1038 - 1048. [Abstract] [Full Text] [PDF]

				B. FRITZSCH, M. BARBACID, and I. SILOS-SANTIAGO Nerve Dependency of Developing and Mature Sensory Receptor Cells Ann. N.Y. Acad. Sci., November 30, 1998; 855(1): 14 - 27. [Abstract] [Full Text] [PDF]

				B. Fritzsch, I. Farinas, and L. F. Reichardt Lack of Neurotrophin 3�Causes Losses of Both Classes of Spiral Ganglion Neurons in the Cochlea in a Region-Specific Fashion J. Neurosci., August 15, 1997; 17(16): 6213 - 6225. [Abstract] [Full Text] [PDF]

				S. Alcantara, J. Frisen, J. A. del Rio, E. Soriano, M. Barbacid, and I. Silos-Santiago TrkB Signaling Is Required for Postnatal Survival of CNS Neurons and Protects Hippocampal and Motor Neurons from Axotomy-Induced Cell Death J. Neurosci., May 15, 1997; 17(10): 3623 - 3633. [Abstract] [Full Text] [PDF]

				L Minichiello and R Klein TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons. Genes & Dev., November 15, 1996; 10(22): 2849 - 2858. [Abstract] [PDF]

				F. A. White, I. Silos-Santiago, D. C. Molliver, M. Nishimura, H. Phillips, M. Barbacid, and W. D. Snider Synchronous Onset of NGF and TrkA Survival Dependence in Developing Dorsal Root Ganglia J. Neurosci., August 1, 1996; 16(15): 4662 - 4672. [Abstract] [Full Text] [PDF]

				L. Pinon, L Minichiello, R Klein, and A. Davies Timing of neuronal death in trkA, trkB and trkC mutant embryos reveals developmental changes in sensory neuron dependence on Trk signalling Development, January 10, 1996; 122(10): 3255 - 3261. [Abstract] [PDF]

				L. Bianchi, J. Conover, B Fritzsch, T DeChiara, R. Lindsay, and G. Yancopoulos Degeneration of vestibular neurons in late embryogenesis of both heterozygous and homozygous BDNF null mutant mice Development, January 6, 1996; 122(6): 1965 - 1973. [Abstract] [PDF]

				L Minichiello, F Piehl, E Vazquez, T Schimmang, T Hokfelt, J Represa, and R Klein Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons Development, January 12, 1995; 121(12): 4067 - 4075. [Abstract] [PDF]