tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman

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What's this?

				E. N. Olson and M. D. Schneider Sizing up the heart: development redux in disease Genes & Dev., August 15, 2003; 17(16): 1937 - 1956. [Full Text] [PDF]

				J. F. Ryan and J. R. Finnerty CnidBase: The Cnidarian Evolutionary Genomics Database Nucleic Acids Res., January 1, 2003; 31(1): 159 - 163. [Abstract] [Full Text] [PDF]

				R. Schwartz and E. Olson Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription Development, January 10, 1999; 126(19): 4187 - 4192. [Abstract] [PDF]

				J. Reecy, X Li, M Yamada, F. DeMayo, C. Newman, R. Harvey, and R. Schwartz Identification of upstream regulatory regions in the heart-expressed homeobox gene Nkx2-5 Development, January 2, 1999; 126(4): 839 - 849. [Abstract] [PDF]

				C. Lien, C Wu, B Mercer, R Webb, J. Richardson, and E. Olson Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer Development, January 1, 1999; 126(1): 75 - 84. [Abstract] [PDF]

				M. Park, C. Lewis, D. Turbay, A. Chung, J.-N. Chen, S. Evans, R. E. Breitbart, M. C. Fishman, S. Izumo, and R. Bodmer Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes PNAS, August 4, 1998; 95(16): 9366 - 9371. [Abstract] [Full Text] [PDF]

				Y. Lee, T. Shioi, H. Kasahara, S. M. Jobe, R. J. Wiese, B. E. Markham, and S. Izumo The Cardiac Tissue-Restricted Homeobox Protein Csx/Nkx2.5 Physically Associates with the Zinc Finger Protein GATA4 and Cooperatively Activates Atrial Natriuretic Factor Gene Expression Mol. Cell. Biol., June 1, 1998; 18(6): 3120 - 3129. [Abstract] [Full Text]

				H. Kasahara, S. Bartunkova, M. Schinke, M. Tanaka, and S. Izumo Cardiac and Extracardiac Expression of Csx/Nkx2.5 Homeodomain Protein Circ. Res., May 19, 1998; 82(9): 936 - 946. [Abstract] [Full Text] [PDF]

				J. T. Thompson, M. S. Rackley, and T. X. O'Brien Upregulation of the cardiac homeobox gene Nkx2-5 (CSX) in feline right ventricular pressure overload Am J Physiol Heart Circ Physiol, May 1, 1998; 274(5): H1569 - H1573. [Abstract] [Full Text] [PDF]

				P. A. Doevendans, P. Ruiz-Lozano, and M. van Bilsen Hunting down nucleic acid binding factors in the cardiovascular system Cardiovasc Res, May 1, 1998; 38(2): 301 - 315. [Abstract] [Full Text] [PDF]

				G. A. Apergis, N. Crawford, D. Ghosh, C. M. Steppan, W. R. Vorachek, P. Wen, and J. Locker A Novel nk-2-related Transcription Factor Associated with Human Fetal Liver and Hepatocellular Carcinoma J. Biol. Chem., January 30, 1998; 273(5): 2917 - 2925. [Abstract] [Full Text] [PDF]

				Y Fu, W Yan, T. Mohun, and S. Evans Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner Development, January 11, 1998; 125(22): 4439 - 4449. [Abstract] [PDF]

				G Ranganayakulu, D. Elliott, R. Harvey, and E. Olson Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice Development, January 8, 1998; 125(16): 3037 - 3048. [Abstract] [PDF]

				G. Serbedzija, J. Chen, and M. Fishman Regulation in the heart field of zebrafish Development, January 3, 1998; 125(6): 1095 - 1101. [Abstract] [PDF]

				Y. M. Lee, T. Park, R. A. Schulz, and Y. Kim Twist-mediated Activation of the NK-4 Homeobox Gene in the Visceral Mesoderm of Drosophila Requires Two Distinct Clusters of E-box Regulatory Elements J. Biol. Chem., July 11, 1997; 272(28): 17531 - 17541. [Abstract] [Full Text] [PDF]

				C Biben and R P Harvey Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development. Genes & Dev., June 1, 1997; 11(11): 1357 - 1369. [Abstract] [PDF]

				Z Yin, X. Xu, and M Frasch Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development Development, January 12, 1997; 124(24): 4971 - 4982. [Abstract] [PDF]

				S. Fisher, E Siwik, D Branellec, K Walsh, and M Watanabe Forced expression of the homeodomain protein Gax inhibits cardiomyocyte proliferation and perturbs heart morphogenesis Development, January 11, 1997; 124(21): 4405 - 4413. [Abstract] [PDF]

				M. Fishman and K. Chien Fashioning the vertebrate heart: earliest embryonic decisions Development, January 6, 1997; 124(11): 2099 - 2117. [Abstract] [PDF]

				Y Zou, S Evans, J Chen, H. Kuo, R. Harvey, and K. Chien CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway Development, January 2, 1997; 124(4): 793 - 804. [Abstract] [PDF]

				I. Shiojima, I. Komuro, T. Mizuno, R. Aikawa, H. Akazawa, T. Oka, T. Yamazaki, and Y. Yazaki Molecular Cloning and Characterization of Human Cardiac Homeobox Gene CSX1 Circ. Res., November 1, 1996; 79(5): 920 - 929. [Abstract] [Full Text]

				J. Chen and M. Fishman Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation Development, January 12, 1996; 122(12): 3809 - 3816. [Abstract] [PDF]

				O. Cleaver, K. Patterson, and P. Krieg Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia Development, January 11, 1996; 122(11): 3549 - 3556. [Abstract] [PDF]

				H. Kasahara, A. Usheva, T. Ueyama, H. Aoki, N. Horikoshi, and S. Izumo Characterization of Homo- and Heterodimerization of Cardiac Csx/Nkx2.5 Homeoprotein J. Biol. Chem., February 9, 2001; 276(7): 4570 - 4580. [Abstract] [Full Text] [PDF]

				C. J. Phiel, V. Gabbeta, L. M. Parsons, D. Rothblat, R. P. Harvey, and K. M. McHugh Differential Binding of an SRF/NK-2/MEF2 Transcription Factor Complex in Normal Versus Neoplastic Smooth Muscle Tissues J. Biol. Chem., September 7, 2001; 276(37): 34637 - 34650. [Abstract] [Full Text] [PDF]