Evolutionary conservation of a cell fate specification gene: the Hydra achaete-scute homolog has proneural activity in Drosophila

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Allende, M. L. and Weinberg, E. S (1994). The expression pattern of two zebrafish achaete-scute homolog ( ash ) genes is altered in the embryonic brain of the cyclops mutant. Dev. Biol 166, 509-530.[Medline]

Alonso, M. C. and Cabrera, C. V (1988). The achaete-scute gene complex of Drosophila melanogaster comprises four homologous genes. EMBO J 7, 2585-2591.[Medline]

Bode, H. R. and David, C. N (1978). Regulation of a multipotent stem cell, the interstitial cell of Hydra. Prog. Biophys. Molec. Biol 33, 189-206.[Medline]

Bode, H. R., Gee, L. W. and Chow, M. A (1990). Neuron differentiation in hydra involves dividing intermediates. Dev. Biol 139, 231-243.[Medline]

Bode, H. R., Heimfeld, S., Chow, M. A. and Huang, L. W (1987). Gland cells arise by differentiation from interstitial cells in Hydra attenuata. Dev. Biol 122, 577-585.[Medline]

Brand, M., Jarman, A. P., Jan, L. Y. and Jan, Y. N (1993). asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation. Development 119, 1-17.[Abstract]

Burglin, T. R., Finney, M., Coulson, A. and Ruvkun, G (1989). Caenorhabditiselegans has scores of homeobox-containing genes. Nature 341, 239-243.[Medline]

Campbell, R. D. and David, C. N (1974). Cell cycle kinetics and development of Hydra attenuata . II. Interstitial cells. J. Cell Sci 16, 349-358.[Abstract/Free Full Text]

Campos-Ortega, J. A. and Jan, Y. N (1991). Genetic and molecular bases of neurogenesis in Drosophila melanogaster. Ann. Rev. Neurosci 14, 399-420.[Medline]

Campuzano, S. and Modolell, J (1992). Patterning of the Drosophila nervous system: the achaete-scute gene complex. Trends Genet 8, 202-208.[Medline]

Campuzano, S., Carramolino, L., Cabrera, C. V., Ruiz-Gomez, M., Villares, R., Boronat, A. and Modolell, J (1985). Molecular genetics of the achaete-scute gene complex of D. melanogaster. Cell 40, 327-338.[Medline]

Canfield, V. A., Xu, K. Y., D'Aquila, T., Shyjan, A. W. and Levenson, R (1992). Molecular cloning and characterization of Na, K-ATPase from Hydra vulgaris : implications for enzyme evolution and ouabain sensitivity. New Biologist 4, 339-48.[Medline]

Cronmiller, C. and Cummings, C. A (1993). The daughterless gene product in Drosophila is a nuclear protein that is broadly expressed throughout the organism during development. Mech. Dev 42, 159-169.[Medline]

David, C. N. and Campbell, R. D (1972). Cell cycle kinetics and development of Hydra attenuata . I. Epithelial cells. J. Cell Sci 11, 557-568.[Abstract/Free Full Text]

David, C. N. and Gierer, A (1974). Cell cycle kinetics and development of Hydra attenuata . III. Nerve and nematocyte differentiation. J. Cell Sci 16, 359-375.[Abstract/Free Full Text]

David, C. N. and Murphy, S (1977). Characterization of interstitial stem cells in hydra by cloning. Dev. Biol 58, 372-383.[Medline]

Davis, R. L., Cheng, P.-F., Lassar, A. B. and Weintraub, H (1990). The Myo D DNA binding domain contains a recognition code for muscle-specific gene activation. Cell 60, 733-746.[Medline]

Dominguez, M. and Campuzano, S (1993). asense , a member of the Drosophilaachaete-scute complex, is a proneural and neural differentiation gene. EMBO J 12, 2049-2060.[Medline]

Dubel, S., Hoffmeister, S. A. and Schaller, C. H (1987). Differentiation pathways of ectodermal epithelial cells in hydra. Differentiation 35, 181-189.[Medline]

Ferreiro, B., Skoglund, P., Bailey, A., Dorsky, R. and Harris, W. A (1992). XASH1 , a Xenopus homolog of achaete-scute : a proneural gene in anterior regions of the vertebrate CNS. Mech. Dev 40, 25-36.

Ferreiro, B., Kintner, C., Zimmerman, K., Anderson, D. and Harris, W. A (1994). XASH genes promote neurogenesis in Xenopus embryos. Development 120, 3649-3655.[Abstract]

Fisher, D. A. and Bode, H. R (1989). Nucleotide sequence of an actin-encoding gene from Hydra attenuata : structural characteristics and evolutionary implications. Gene 84, 55-64.[Medline]

Ghysen, A. and Dambly-Chaudiere, C (1989). Genesis of the Drosophila peripheral nervous system. Trends Genet 5, 251-255.[Medline]

Gonzalez, F., Romain, S., Cubas, P., Modolell, J. and Campuzano, S (1989). Molecular analysis of the asense gene, a member of the achaete-scute complex of Drosophila melanogaster , and its novel role in optic lobe development. EMBO J 8, 3553-3562.[Medline]

Gonzalez-Crespo, S. and Levine, M (1993). Interactions between dorsal and helix-loop-helix proteins initiate the differentiation of the embryonic mesoderm and neuroectoderm in Drosophila. Genes Dev 7, 1703-1713.[Abstract/Free Full Text]

Guillemot, F. and Joyner, A. L (1993). Dynamic expression of the murine achaete-scute homologue Mash-1 in the developing nervous system. Mech. Dev 42, 171-185.[Medline]

Guillemot, F., Lo, L.-C., Johnson, J. E., Auerbach, A., Anderson, D. J. andJoyner, A. L (1993). Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell 75, 463-476.[Medline]

Guillemot, F., Nagy, A., Auerbach, A., Rossant, J., and Joyner, A. L (1994). Essential role of MASH-2 in extraembryonic development. Nature 371, 333-336.[Medline]

Hinz, U., Giebel, B. and Campos-Ortega, J. A (1994). The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes. Cell 76, 77-87.[Medline]

Jarman, A. P., Brand, M., Jan, L. Y. and Jan, Y. N (1993). The regulation and function of the helix-loop-helix gene, asense , in Drosophila neural precursors. Development 119, 19-29.[Abstract]

Jasoni, C. L., Walker, M. B., Morris, M. D. and Reh, T. A (1994). A chicken achaete-scute homolog (CASH-1) is expressed in a temporally and spatially discrete manner in the developing nervous system. Development 120, 769-783.[Abstract]

Johnson, J. E., Birren, S. J. and Anderson, D. J (1990). Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors. Nature 346, 858-861.[Medline]

Johnson, J. E., Birren, S. J., Saito, T. and Anderson, D. J (1992). DNA binding and transcriptional regulatory activity of mammalian achaete-scute homologous (MASH) proteins revealed by interaction with a muscle-specific enhancer. Proc. Natl. Acad. Sci. USA 89, 3596-3600.[Abstract/Free Full Text]

Kurz, E. M., Holstein, T.W., Petri, B. M., Engel, J. and David, C. N (1991). Mini-collagens in hydra nematocytes. J. Cell Biol 115, 1159-1169.[Abstract/Free Full Text]

Lo, L.-C., Johnson, J. E., Wuenschell, C. W., Saito, T. and Anderson, D. J (1991). Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells. Genes Dev 5, 1524-1537.[Abstract/Free Full Text]

Martinez, C. and Modolell, J (1991). Cross-regulatory interactions between the proneural achaete and scute genes of Drosophila. Science 251, 1485-1487.[Abstract/Free Full Text]

McGinnis, N., Kuziora, M. A. and McGinnis, W (1990). Human Hox-4.2 and DrosophilaDeformed encode similar regulatory specificities in Drosophila embryos and larvae. Cell 63, 969-976.[Medline]

Murre, C., McCaw, P. S. and Baltimore, D (1989). A new DNA binding and dimerization motif in immunoglobin enhancer binding, daughterless , Myo D and myc proteins. Cell 56, 777-783.[Medline]

Murre, C., McCaw, P. S., Vassin, H., Caudy, M., Jan, L. Y., Jan, Y. N., Cabrera, C. V., Buskin, J. N., Hauschka, S. D., Lassar, A. B., Weintraub, H. and Baltimore, D (1989). Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58, 537-544.[Medline]

Nardelli-Haefliger, D. and Shankland, M (1992). Lox 2 , a putative leech segment identity gene, is expressed in the same segmental domain in different stem cell lineages. Development 116, 697-710.[Abstract]

Parkhurst, S. M., Bopp, D. and Ish-Horowitz, D (1990). X:A ratio, the primary sex-determining signal in Drosophila , is transduced by helix-loop-helix proteins. Cell 63, 1179-1191.[Medline]

Parkhurst, S., M., Lipshitz, H. D. and Ish-Horowitz, D (1993). achaete-scute feminizing activities and Drosophila sex determination. Development 117, 737-749.[Abstract]

Rodriguez, I., Hernandez, R., Modolell, J. and Ruiz-Gomez, M (1990). Competence to develop sensory organs is temporally and spatially regulated in Drosophila epidermal primordia. EMBO J 9, 3583-3592.[Medline]

Rubin, G. M. and Spradling, A. C (1982). Genetic transformation of Drosophila with transposable element vectors. Science 218, 348-353.[Abstract/Free Full Text]

Sacks, P. G. and Davis, L. E (1979). Production of nerveless Hydra attenuata by hydroxyurea treatments. J. Cell Sci 37, 189-203.[Abstract]

Sarras, M. P., Jr., Yan, L., Grens, A., Zhang, X., Agbas, A., Huff, J. K., St. John, P. L. and Abrahamson, D. R (1994). Cloning and biological function of laminin in Hydra vulgaris. Dev. Biol 164, 312-324.[Medline]

Schlaepfer, D. D., Bode, H. R. and Haigler, H. T (1992). Distinct cellular expression pattern of annexins in Hydra vulgaris. J. Cell Biol 118, 911-928.[Abstract/Free Full Text]

Shenk, M. A., Bode, H. R. and Steele, R. E (1993). Expression of Cnox-2 , a HOM/HOX homeobox gene in hydra, is correlated with axial pattern formation. Development 117, 657-667.[Abstract]

Shenk, M. A., Gee, L., Steele, R. E. and Bode, H. R (1993). Expression of Cnox-2 , a HOM/HOX gene, is suppressed during head formation in Hydra. Dev. Biol 160, 108-118.[Medline]

Turner, D. and Weintraub, H (1994). Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes & Dev 8, 1434-1447.[Abstract/Free Full Text]

Van Doren, M., Ellis, H. M. and Posakony, J. W (1991). The Drosophila extramacrochetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes. Development 113, 245-255.[Abstract]

Villares, R. and Cabrera, C. V (1987). The achaete-scute gene complex of D. melanogaster : conserved domains in a subset of the genes required for neurogenesis and their homology to myc. Cell 50, 415-424.[Medline]

Voronova, A. and Baltimore, D (1990). Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains. Proc. Natl. Acad. Sci. USA 87, 4722-4726.[Abstract/Free Full Text]

Wood, W. I., Gitschier, J., Lasky, L. A. and Lawn, R. M (1985). Base composition-independent hybridization in tetramethylammonium chloride: a method for oligonucleotide screening of highly complex gene libraries. Proc. Natl. Acad. Sci. USA 82, 1585-1588.[Abstract/Free Full Text]

Zimmerman, K., Shih, J., Bars, J., Collazo,A. and Anderson, D. J (1993). XASH-3 , a novel Xenopus achaete-scute homolog, provides an early marker of planar neural induction and position along the mediolateral axis of the neural plate. Development 119, 221-232.[Abstract]

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				S. J. Fowler, S. Jose, X. Zhang, R. Deutzmann, M. P. Sarras Jr., and R. P. Boot-Handford Characterization of Hydra Type IV Collagen. TYPE IV COLLAGEN IS ESSENTIAL FOR HEAD REGENERATION AND ITS EXPRESSION IS UP-REGULATED UPON EXPOSURE TO GLUCOSE J. Biol. Chem., December 8, 2000; 275(50): 39589 - 39599. [Abstract] [Full Text] [PDF]