Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death

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A. Forrai, K. Boyle, A. H. Hart, L. Hartley, S. Rakar, T. A. Willson, K. M. Simpson, A. W. Roberts, W. S. Alexander, A. K. Voss, et al.
Absence of Suppressor of Cytokine Signalling 3 Reduces Self-Renewal and Promotes Differentiation in Murine Embryonic Stem Cells
Stem Cells, March 1, 2006; 24(3): 604 - 614.
[Abstract] [Full Text] [PDF]

S. Oberle, A. Schober, V. Meyer, B. Holtmann, C. Henderson, M. Sendtner, and K. Unsicker
Loss of Leukemia Inhibitory Factor Receptor beta or Cardiotrophin-1 Causes Similar Deficits in Preganglionic Sympathetic Neurons and Adrenal Medulla
J. Neurosci., February 8, 2006; 26(6): 1823 - 1832.
[Abstract] [Full Text] [PDF]

E. Dimitriadis, C.A. White, R.L. Jones, and L.A. Salamonsen
Cytokines, chemokines and growth factors in endometrium related to implantation
Hum. Reprod. Update, November 1, 2005; 11(6): 613 - 630.
[Abstract] [Full Text] [PDF]

S. J Kimber
Leukaemia inhibitory factor in implantation and uterine biology
Reproduction, August 1, 2005; 130(2): 131 - 145.
[Abstract] [Full Text] [PDF]

E. D. Watson and J. C. Cross
Development of Structures and Transport Functions in the Mouse Placenta
Physiology, June 1, 2005; 20(3): 180 - 193.
[Abstract] [Full Text] [PDF]

B. J. Jenkins, A. W. Roberts, M. Najdovska, D. Grail, and M. Ernst
The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis
Blood, May 1, 2005; 105(9): 3512 - 3520.
[Abstract] [Full Text] [PDF]

T. Kuroda, M. Tada, H. Kubota, H. Kimura, S.-y. Hatano, H. Suemori, N. Nakatsuji, and T. Tada
Octamer and Sox Elements Are Required for Transcriptional cis Regulation of Nanog Gene Expression
Mol. Cell. Biol., March 15, 2005; 25(6): 2475 - 2485.
[Abstract] [Full Text] [PDF]

I. Dorval-Coiffec, J.-G. Delcros, H. Hakovirta, J. Toppari, B. Jegou, and C. Piquet-Pellorce
Identification of the Leukemia Inhibitory Factor Cell Targets Within the Rat Testis
Biol Reprod, March 1, 2005; 72(3): 602 - 611.
[Abstract] [Full Text] [PDF]

L. AGHAJANOVA
Leukemia Inhibitory Factor and Human Embryo Implantation
Ann. N.Y. Acad. Sci., December 1, 2004; 1034(1): 176 - 183.
[Abstract] [Full Text] [PDF]

F. L Lopes, J. A Desmarais, and B. D Murphy
Embryonic diapause and its regulation
Reproduction, December 1, 2004; 128(6): 669 - 678.
[Abstract] [Full Text] [PDF]

M. C. Horowitz, Y. Xi, D. L. Pflugh, D. G. T. Hesslein, D. G. Schatz, J. A. Lorenzo, and A. L. M. Bothwell
Pax5-Deficient Mice Exhibit Early Onset Osteopenia with Increased Osteoclast Progenitors
J. Immunol., December 1, 2004; 173(11): 6583 - 6591.
[Abstract] [Full Text] [PDF]

T. Sumi, Y. Fujimoto, N. Nakatsuji, and H. Suemori
STAT3 Is Dispensable for Maintenance of Self-Renewal in Nonhuman Primate Embryonic Stem Cells
Stem Cells, September 1, 2004; 22(5): 861 - 872.
[Abstract] [Full Text] [PDF]

V. P. Eswarakumar, M. C. Horowitz, R. Locklin, G. M. Morriss-Kay, and P. Lonai
A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis
PNAS, August 24, 2004; 101(34): 12555 - 12560.
[Abstract] [Full Text] [PDF]

R. R. Gonzalez, B. R. Rueda, M. P. Ramos, R. D. Littell, S. Glasser, and P. C. Leavis
Leptin-Induced Increase in Leukemia Inhibitory Factor and Its Receptor by Human Endometrium Is Partially Mediated by Interleukin 1 Receptor Signaling
Endocrinology, August 1, 2004; 145(8): 3850 - 3857.
[Abstract] [Full Text] [PDF]

R. K. Humphrey, G. M. Beattie, A. D. Lopez, N. Bucay, C. C. King, M. T. Firpo, S. Rose-John, and A. Hayek
Maintenance of Pluripotency in Human Embryonic Stem Cells Is STAT3 Independent
Stem Cells, July 1, 2004; 22(4): 522 - 530.
[Abstract] [Full Text] [PDF]

I. Classen-Linke, G. Muller-Newen, P.C. Heinrich, H.M. Beier, and U. von Rango
The cytokine receptor gp130 and its soluble form are under hormonal control in human endometrium and decidua
Mol. Hum. Reprod., July 1, 2004; 10(7): 495 - 504.
[Abstract] [Full Text] [PDF]

S. K. Dey, H. Lim, S. K. Das, J. Reese, B. C. Paria, T. Daikoku, and H. Wang
Molecular Cues to Implantation
Endocr. Rev., June 1, 2004; 25(3): 341 - 373.
[Abstract] [Full Text] [PDF]

N. Mackman
Role of Tissue Factor in Hemostasis, Thrombosis, and Vascular Development
Arterioscler. Thromb. Vasc. Biol., June 1, 2004; 24(6): 1015 - 1022.
[Abstract] [Full Text] [PDF]

M. De Felici, M.L. Scaldaferri, M. Lobascio, S. Iona, V. Nazzicone, F.G. Klinger, and D. Farini
Experimental approaches to the study of primordial germ cell lineage and proliferation
Hum. Reprod. Update, May 1, 2004; 10(3): 197 - 206.
[Abstract] [Full Text] [PDF]

R. Abir, B. Fisch, S. Jin, M. Barnnet, S. Freimann, R. Van den Hurk, D. Feldberg, S. Nitke, H. Krissi, and A. Ao
Immunocytochemical detection and RT-PCR expression of leukaemia inhibitory factor and its receptor in human fetal and adult ovaries
Mol. Hum. Reprod., May 1, 2004; 10(5): 313 - 319.
[Abstract] [Full Text] [PDF]

T. A. Rodriguez, D. B. Sparrow, A. N. Scott, S. L. Withington, J. I. Preis, J. Michalicek, M. Clements, T. E. Tsang, T. Shioda, R. S. P. Beddington, et al.
Cited1 Is Required in Trophoblasts for Placental Development and for Embryo Growth and Survival
Mol. Cell. Biol., January 1, 2004; 24(1): 228 - 244.
[Abstract] [Full Text] [PDF]

P. Fedorcsak and R. Storeng
Effects of Leptin and Leukemia Inhibitory Factor on Preimplantation Development and STAT3 Signaling of Mouse Embryos In Vitro
Biol Reprod, November 1, 2003; 69(5): 1531 - 1538.
[Abstract] [Full Text] [PDF]

M. Tanaka, Y. Hirabayashi, T. Sekiguchi, T. Inoue, M. Katsuki, and A. Miyajima
Targeted disruption of oncostatin M receptor results in altered hematopoiesis
Blood, November 1, 2003; 102(9): 3154 - 3162.
[Abstract] [Full Text] [PDF]

Y. P. Ng, W. He, and N. Y. Ip
Leukemia Inhibitory Factor Receptor Signaling Negatively Modulates Nerve Growth Factor-induced Neurite Outgrowth in PC12 Cells and Sympathetic Neurons
J. Biol. Chem., October 3, 2003; 278(40): 38731 - 38739.
[Abstract] [Full Text] [PDF]

K. A. Molyneaux, K. Schaible, and C. Wylie
GP130, the shared receptor for the LIF/IL6 cytokine family in the mouse, is not required for early germ cell differentiation, but is required cell-autonomously in oocytes for ovulation
Development, September 15, 2003; 130(18): 4287 - 4294.
[Abstract] [Full Text] [PDF]

J. Wang, Q. Chen, J. Corne, Z. Zhu, C. G. Lee, V. Bhandari, R. J. Homer, and J. A. Elias
Pulmonary Expression of Leukemia Inhibitory Factor Induces B Cell Hyperplasia and Confers Protection in Hyperoxia
J. Biol. Chem., August 15, 2003; 278(33): 31226 - 31232.
[Abstract] [Full Text] [PDF]

B. Stankoff, M.-S. Aigrot, F. Noel, A. Wattilliaux, B. Zalc, and C. Lubetzki
Ciliary Neurotrophic Factor (CNTF) Enhances Myelin Formation: A Novel Role for CNTF and CNTF-Related Molecules
J. Neurosci., November 1, 2002; 22(21): 9221 - 9227.
[Abstract] [Full Text] [PDF]

P. Palmqvist, E. Persson, H. H. Conaway, and U. H. Lerner
IL-6, Leukemia Inhibitory Factor, and Oncostatin M Stimulate Bone Resorption and Regulate the Expression of Receptor A

				J. Lorenzo, M. Horowitz, and Y. Choi Osteoimmunology: Interactions of the Bone and Immune System Endocr. Rev., June 1, 2008; 29(4): 403 - 440. [Abstract] [Full Text] [PDF]

				J. S. Fitzgerald, T. G. Poehlmann, E. Schleussner, and U. R. Markert Trophoblast invasion: the role of intracellular cytokine signalling via signal transducer and activator of transcription 3 (STAT3) Hum. Reprod. Update, April 17, 2008; (2008) dmn010v1. [Abstract] [Full Text] [PDF]

				W. V. Ingman and R. L. Jones Cytokine knockouts in reproduction: the use of gene ablation to dissect roles of cytokines in reproductive biology Hum. Reprod. Update, March 1, 2008; 14(2): 179 - 192. [Abstract] [Full Text] [PDF]

				N. de la Iglesia, G. Konopka, S. V. Puram, J. A. Chan, R. M. Bachoo, M. J. You, D. E. Levy, R. A. DePinho, and A. Bonni Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway Genes & Dev., February 15, 2008; 22(4): 449 - 462. [Abstract] [Full Text] [PDF]

				J. Seita, M. Asakawa, J. Ooehara, S.-i. Takayanagi, Y. Morita, N. Watanabe, K. Fujita, M. Kudo, J. Mizuguchi, H. Ema, et al. Interleukin-27 directly induces differentiation in hematopoietic stem cells Blood, February 15, 2008; 111(4): 1903 - 1912. [Abstract] [Full Text] [PDF]

				T. Ding, H. Song, X. Wang, A. Khatua, and B. C Paria Leukemia inhibitory factor ligand-receptor signaling is important for uterine receptivity and implantation in golden hamsters (Mesocricetus auratus) Reproduction, January 1, 2008; 135(1): 41 - 53. [Abstract] [Full Text] [PDF]

				H. Wang, H. Xie, X. Sun, S. Tranguch, H. Zhang, X. Jia, D. Wang, S. K. Das, B. Desvergne, W. Wahli, et al. Stage-specific Integration of Maternal and Embryonic Peroxisome Proliferator-activated Receptor {delta} Signaling Is Critical to Pregnancy Success J. Biol. Chem., December 28, 2007; 282(52): 37770 - 37782. [Abstract] [Full Text] [PDF]

				C. A. White, J.-G. Zhang, L. A. Salamonsen, M. Baca, W. D. Fairlie, D. Metcalf, N. A. Nicola, L. Robb, and E. Dimitriadis From the Cover: Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: A nonhormonal contraceptive strategy PNAS, December 4, 2007; 104(49): 19357 - 19362. [Abstract] [Full Text] [PDF]

				T. Huyton, J.-G. Zhang, C. S. Luo, M.-Z. Lou, D. J. Hilton, N. A. Nicola, and T. P. J. Garrett An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor PNAS, July 31, 2007; 104(31): 12737 - 12742. [Abstract] [Full Text] [PDF]

				S. Kuure, A. Popsueva, M. Jakobson, K. Sainio, and H. Sariola Glycogen Synthase Kinase-3 Inactivation and Stabilization of beta-Catenin Induce Nephron Differentiation in Isolated Mouse and Rat Kidney Mesenchymes J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1130 - 1139. [Abstract] [Full Text] [PDF]

				D. Falconi, K. Oizumi, and J. E. Aubin Leukemia Inhibitory Factor Influences the Fate Choice of Mesenchymal Progenitor Cells Stem Cells, February 1, 2007; 25(2): 305 - 312. [Abstract] [Full Text] [PDF]

				R. E. Davey and P. W. Zandstra Spatial Organization of Embryonic Stem Cell Responsiveness to Autocrine Gp130 Ligands Reveals an Autoregulatory Stem Cell Niche Stem Cells, November 1, 2006; 24(11): 2538 - 2548. [Abstract] [Full Text] [PDF]

				T. Mohri, Y. Fujio, M. Maeda, T. Ito, T. Iwakura, Y. Oshima, Y. Uozumi, M. Segawa, H. Yamamoto, T. Kishimoto, et al. Leukemia Inhibitory Factor Induces Endothelial Differentiation in Cardiac Stem Cells J. Biol. Chem., March 10, 2006; 281(10): 6442 - 6447. [Abstract] [Full Text] [PDF]

				A. Forrai, K. Boyle, A. H. Hart, L. Hartley, S. Rakar, T. A. Willson, K. M. Simpson, A. W. Roberts, W. S. Alexander, A. K. Voss, et al. Absence of Suppressor of Cytokine Signalling 3 Reduces Self-Renewal and Promotes Differentiation in Murine Embryonic Stem Cells Stem Cells, March 1, 2006; 24(3): 604 - 614. [Abstract] [Full Text] [PDF]

				S. Oberle, A. Schober, V. Meyer, B. Holtmann, C. Henderson, M. Sendtner, and K. Unsicker Loss of Leukemia Inhibitory Factor Receptor beta or Cardiotrophin-1 Causes Similar Deficits in Preganglionic Sympathetic Neurons and Adrenal Medulla J. Neurosci., February 8, 2006; 26(6): 1823 - 1832. [Abstract] [Full Text] [PDF]

				E. Dimitriadis, C.A. White, R.L. Jones, and L.A. Salamonsen Cytokines, chemokines and growth factors in endometrium related to implantation Hum. Reprod. Update, November 1, 2005; 11(6): 613 - 630. [Abstract] [Full Text] [PDF]

				S. J Kimber Leukaemia inhibitory factor in implantation and uterine biology Reproduction, August 1, 2005; 130(2): 131 - 145. [Abstract] [Full Text] [PDF]

				E. D. Watson and J. C. Cross Development of Structures and Transport Functions in the Mouse Placenta Physiology, June 1, 2005; 20(3): 180 - 193. [Abstract] [Full Text] [PDF]

				B. J. Jenkins, A. W. Roberts, M. Najdovska, D. Grail, and M. Ernst The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis Blood, May 1, 2005; 105(9): 3512 - 3520. [Abstract] [Full Text] [PDF]

				T. Kuroda, M. Tada, H. Kubota, H. Kimura, S.-y. Hatano, H. Suemori, N. Nakatsuji, and T. Tada Octamer and Sox Elements Are Required for Transcriptional cis Regulation of Nanog Gene Expression Mol. Cell. Biol., March 15, 2005; 25(6): 2475 - 2485. [Abstract] [Full Text] [PDF]

				I. Dorval-Coiffec, J.-G. Delcros, H. Hakovirta, J. Toppari, B. Jegou, and C. Piquet-Pellorce Identification of the Leukemia Inhibitory Factor Cell Targets Within the Rat Testis Biol Reprod, March 1, 2005; 72(3): 602 - 611. [Abstract] [Full Text] [PDF]

				L. AGHAJANOVA Leukemia Inhibitory Factor and Human Embryo Implantation Ann. N.Y. Acad. Sci., December 1, 2004; 1034(1): 176 - 183. [Abstract] [Full Text] [PDF]

				F. L Lopes, J. A Desmarais, and B. D Murphy Embryonic diapause and its regulation Reproduction, December 1, 2004; 128(6): 669 - 678. [Abstract] [Full Text] [PDF]

				M. C. Horowitz, Y. Xi, D. L. Pflugh, D. G. T. Hesslein, D. G. Schatz, J. A. Lorenzo, and A. L. M. Bothwell Pax5-Deficient Mice Exhibit Early Onset Osteopenia with Increased Osteoclast Progenitors J. Immunol., December 1, 2004; 173(11): 6583 - 6591. [Abstract] [Full Text] [PDF]

				T. Sumi, Y. Fujimoto, N. Nakatsuji, and H. Suemori STAT3 Is Dispensable for Maintenance of Self-Renewal in Nonhuman Primate Embryonic Stem Cells Stem Cells, September 1, 2004; 22(5): 861 - 872. [Abstract] [Full Text] [PDF]

				V. P. Eswarakumar, M. C. Horowitz, R. Locklin, G. M. Morriss-Kay, and P. Lonai A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis PNAS, August 24, 2004; 101(34): 12555 - 12560. [Abstract] [Full Text] [PDF]

				R. R. Gonzalez, B. R. Rueda, M. P. Ramos, R. D. Littell, S. Glasser, and P. C. Leavis Leptin-Induced Increase in Leukemia Inhibitory Factor and Its Receptor by Human Endometrium Is Partially Mediated by Interleukin 1 Receptor Signaling Endocrinology, August 1, 2004; 145(8): 3850 - 3857. [Abstract] [Full Text] [PDF]

				R. K. Humphrey, G. M. Beattie, A. D. Lopez, N. Bucay, C. C. King, M. T. Firpo, S. Rose-John, and A. Hayek Maintenance of Pluripotency in Human Embryonic Stem Cells Is STAT3 Independent Stem Cells, July 1, 2004; 22(4): 522 - 530. [Abstract] [Full Text] [PDF]

				I. Classen-Linke, G. Muller-Newen, P.C. Heinrich, H.M. Beier, and U. von Rango The cytokine receptor gp130 and its soluble form are under hormonal control in human endometrium and decidua Mol. Hum. Reprod., July 1, 2004; 10(7): 495 - 504. [Abstract] [Full Text] [PDF]

				S. K. Dey, H. Lim, S. K. Das, J. Reese, B. C. Paria, T. Daikoku, and H. Wang Molecular Cues to Implantation Endocr. Rev., June 1, 2004; 25(3): 341 - 373. [Abstract] [Full Text] [PDF]