The induction of multiple cell cycle events precedes target-related neuronal death

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Herrup, K.
	Articles by Busser, J. C.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Herrup, K.
	Articles by Busser, J. C.


Social Bookmarking

	What's this?

al-Ubaidi, M. R., Hollyfield, J. G., Overbeek, P. A. and Baehr, W (1992). Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice. Proc. Natl Acad. Sci. USA 89, 1194-1198.[Abstract/Free Full Text]

Bantle, J. and Hahn, W (1976). Complexity and characterization of polyadenylated RNA in the mouse brain. Cell 8, 139-150.[Medline]

Boise, L. H., Gonz\207lez-Garc\222a, M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, X., Nu\226ez, G. and Thompson, C. B (1993). bcl-x, abcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74, 597-608.[Medline]

Bowen, I. D (1993). Apoptosis or programmed cell death?. Cell Biol. Int. Rep 17, 365-380.

Bravo, R., Frank, R., Blundell, P. and MacDonald-Bravo, H (1987). PCNA is the auxiliary protein of DNA polymerase-delta. Nature 326, 515-520.[Medline]

Caddy, K. W. T. and Biscoe, T. J (1979). Structural and quantitative studies on the normal C3H and lurcher mutant mouse. Phil. Trans. Roy. Soc. (Lond.) B 287, 167-201.[Abstract/Free Full Text]

Christakos, S., Gabrielides, C. and Rhoten, W (1989). Vitamin D-dependent calcium binding proteins: chemistry, distribution, functional considerations and molecular biology. Endocrine Rev 10, 3-26.[Abstract/Free Full Text]

Clarke, A., Maandag, E., van Roon, M., van der Lugt, N., van der Valk, M., Hooper, M., Berns, A. and te Riele, H (1992). Requirement for a functional Rb-1 gene in murine development. Nature 359, 328-330.[Medline]

Driscoll, M. and Chalfie, M (1992). Developmental and abnormal cell death in C. elegans. Trends in Neurosci 15, 15-19.[Medline]

Dumesnil-Bousez, N. and Sotelo, C (1992). Early development of the Lurcher cerebellum: Purkinje cell alterations and impairment of synaptogenesis. J Neurocytol 21, 506-29.[Medline]

Earnshaw, W. C. and Pluta, A. F (1994). Mitosis. BioEssays 19, 639-643.

Freeman, R., Estus, S. and Johnson, E (1994). Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death. Neuron 12, 343-355.[Medline]

Gagliardini, V., Fernandez, P.-A., Lee, R., Drexler, H., Rotello, R., Fishman, M. and Yuan, J (1994). Prevention of vertebrate neuronal death by the crmA gene. Science 263, 826-828.[Abstract/Free Full Text]

Goodrich, D., Wang, N., Qian, Y., Lee, E. and Lee, W (1991). The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell 67, 293-302.[Medline]

Hartwell, L. H. and Weinert, T. A (1989). Checkpoints: controls that ensure the order of cell cycle events. Science 246, 629-634.[Abstract/Free Full Text]

He, X. and Rosenfeld, M (1991). Mechanisms of complex transcriptional regulation: implications for brain development. Neuron 7, 183-196.[Medline]

Heintz, N (1993). Cell death and the cell cycle: a relationship between transformation and neurodegeneration?. Trends Biochem. Sci 18, 157-159.[Medline]

Herrup, K. and Mullen, R. J (1979). Regional variation and absence of large neurons in the cerebellum of the staggerer mouse. Brain Res 172, 1-12.[Medline]

Herrup, K. and Mullen, R. J (1979). Staggerer chimeras: intrinsic nature of Purkinje cell defects and implications for normal cerebellar development. Brain Res 178, 443-457.[Medline]

Hirano, A. and Dembitzer, H (1976). The fine structure of the astrocytes in the adult staggerer. J. Neuropathol. Exp. Neurol 35, 63-74.[Medline]

Jacks, T., Fazeli, A., Schmitt, E., Bronson, R., Goodell, M. and Weinberg, R (1992). Effects of an Rb mutation in the mouse. Nature 359, 295-300.[Medline]

Landis, D. M. D. and Sidman, R. L (1978). Electron microscopic analysis of postnatal histogenesis in the cerebellar cortex of staggerer mutant mice. J. Comp. Neurol 179, 831-863.[Medline]

Lee, E. Y.-H. P., Chang, C.-Y., Hu, N., Wang, Y.-C. J., Lai, C.-C., Herrup, K., Lee, W.-H. and Bradley, A (1992). Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 359, 288-294.[Medline]

Lee, E. Y.-H. P., Hu, N., Yuan, S.-S. F., Cox, L. A., Bradley, A., Lee, W.-H. and Herrup, K (1994). Dual roles of the RB protein in cell cycle regulation and neuron differentiation. Genes Dev 8, 2008-2021.[Abstract/Free Full Text]

Martin, D., Schmidt, R., DeStefano, P., Lowry, O., Carter, J. and Johnson, E (1988). Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation. J. Cell Biol 106, 829-844.[Abstract/Free Full Text]

Messer, A., Eisenberg, B. and Plummer, J (1991). The Lurcher cerebellar mutant phenotype is not expressed on a staggerer mutant background. J. Neurosci 11, 2295-302.[Abstract]

Messer, A., Plummer-Siegard, J. and Eisenberg, B (1990). Staggerer mutant mouse Purkinje cells do not contain detectable calmodulin mRNA. J. Neurochem 55, 293-302.[Medline]

Messer, A., Savage, M. and Carter, T. P (1981). Thymidine kinase activity is reduced in the developing staggerer cerebellum. J. Neurochem 37, 1610-2.[Medline]

Milner, R. and Sutcliffe, J (1983). Gene expression in rat brain. Nucleic Acids Res 11, 5497-5520.[Abstract/Free Full Text]

Miura, M., Zhu, H., Rotello, R., Hartwieg, E. and Yuan, J (1993). Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75, 653-660.[Medline]

Mullen, R., Buck, C. and Smith, A (1992). NeuN, a neuronal specific nuclear protein in vertebrates. Development 116, 201-211.[Abstract]

Oppenheim, R., Prevette, D., Tytello, M. and Homma, S (1990). Naturally occurring and induced cell death in the chick embryo in vivo requires protein and RNA synthesis. Dev. Biol 138, 104-113.[Medline]

Pittman, R. H. and Oppenheim, R. W (1978). Neuromuscular blockade increases motoneurone survival during normal cell death in the chick embryo. Nature 271, 364-366.[Medline]

Reed, J. C (1994). Bcl-2 and the regulation of programmed cell death. J. Cell Biol 124, 1-6.[Free Full Text]

Schwartz, L. M. and Osborne, B. A (1993). Programmed cell death, apoptosis and killer genes. Immunol. Today 14, 582-590.[Medline]

Schwartzman, R. A. and Cidlowski, J. A (1993). Apoptosis: The biochemistry and molecular biology of programmed cell death. Endocrin. Rev 14, 133-151.[Abstract/Free Full Text]

Scott, S. and Davies, A (1990). Inhibition of protein synthesis prevents cell death in sensory and parasympathetic neurons deprived of neurotrophic factor in vitro. J. Neurobiol 21, 630-638.[Medline]

Sherr, C (1993). Mammalian G1cyclins. Cell 73, 1059-1065.[Medline]

Smeyne, R., Vendrell, M., Hayward, M., Baker, S., Miao, G., Schilling, K., Robertson, L., Curran, T. and Morgan, J (1993). Continuous c-fos expression precedes programmed cell death in vivo. Nature 363, 166-169.[Medline]

Sotelo, C. and Changeux, J.-P (1974). Transsynaptic degeneration \324encascade' in cerebellar cortex of staggerer mutant mice. Brain Res 67, 519-526.[Medline]

Taber-Pierce, E (1973). Time of origin of neurons in the brain stem of the mouse. Prog. Brain Res 40, 53-65.[Medline]

Tano, D., Napieralski, J., Eisenman, L., Messer, A., Plummer, J. and Hawkes, R (1992). Novel developmental boundary in the cerebellum revealed by zebrin expression in the lurcher (Lc/+) mutant mouse. J. Comp. Neurol 323, 128-36.[Medline]

Vandaele, S., Nordquist, D. T., Feddersen, R. M., Tretjakoff, I., Peterson, A. C. and Orr, H. T (1991). Purkinje cell protein-2 regulatory regions and transgene expression in cerebellar compartments. Genes Dev 5, 1136-48.[Abstract/Free Full Text]

Weinert, T., Kiser, G. and Hartwell, L (1994). Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 8, 652-665.[Abstract/Free Full Text]

Wetts, R. and Herrup, K (1982). Interaction of granule, Purkinje and inferior olivary neurons in lurcher chimeric mice. II. Granule cell death. Brain Res 250, 358-362.[Medline]

Wetts, R. and Herrup, K (1982). Interaction of granule, Purkinje and olivary neurons in lurcher chimeric mice. I. Qualitative studies. J. Embryol. Exp. Morphol 68, 87-98.[Medline]

Whitaker, M. and Patel, R (1990). Calcium and cell cycle control. Development 108, 525-542.[Abstract/Free Full Text]

Williams, R. W. and Herrup, K (1988). Control of cell number in the nervous system. Ann. Rev. Neurosci 11, 423-453.[Medline]

Yonish-Rouach, E., Grunwald, D., Wilder, S., Kimchi, A., May, E., Lawrence, J. J., May, P. and Oren, M (1993). p53-Mediated cell death: Relationship to cell cycle control. Mol. Cell Biol 13, 1415-1423.[Abstract/Free Full Text]

Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M. and Horvitz, H. R (1993). The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1beta-converting enzyme. Cell 75, 641-652.[Medline]

Zanjani, H., Mariani, J. and Herrup, K (1990). Cell loss in the inferior olive of the staggerer mutant mouse is an indirect effect of the gene. J. Neurogenet 6, 229-241.[Medline]

Zhong, L., Sarafian, T., Kane, D. J., Charles, A. C., Mah, S. P., Edwards, R. H. and Bredesen, D. E (1993). bcl-2 inhibits death of central neural cells induced by multiple agents. Proc. Natl Acad. Sci. USA 90, 4533-4537.[Abstract/Free Full Text]

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

Technorati

Twitter What's this?

This article has been cited by other articles:

J. Zhang, S. A. Cicero, L. Wang, R. R. Romito-DiGiacomo, Y. Yang, and K. Herrup
Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons
PNAS, June 24, 2008; 105(25): 8772 - 8777.
[Abstract] [Full Text] [PDF]

S. A. Rimkus, R. J. Katzenberger, A. T. Trinh, G. E. Dodson, R. S. Tibbetts, and D. A. Wassarman
Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia
Genes & Dev., May 1, 2008; 22(9): 1205 - 1220.
[Abstract] [Full Text] [PDF]

L. Wang, R. Wang, and K. Herrup
E2F1 Works as a Cell Cycle Suppressor in Mature Neurons
J. Neurosci., November 14, 2007; 27(46): 12555 - 12564.
[Abstract] [Full Text] [PDF]

L. Ferraiuolo, P. R. Heath, H. Holden, P. Kasher, J. Kirby, and P. J. Shaw
Microarray Analysis of the Cellular Pathways Involved in the Adaptation to and Progression of Motor Neuron Injury in the SOD1 G93A Mouse Model of Familial ALS
J. Neurosci., August 22, 2007; 27(34): 9201 - 9219.
[Abstract] [Full Text] [PDF]

Q. Liu, J. Zhang, H. Zhu, C. Qin, Q. Chen, and B. Zhao
Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model
FASEB J, January 1, 2007; 21(1): 61 - 73.
[Abstract] [Full Text] [PDF]

Y. Yang, N. H. Varvel, B. T. Lamb, and K. Herrup
Ectopic Cell Cycle Events Link Human Alzheimer's Disease and Amyloid Precursor Protein Transgenic Mouse Models
J. Neurosci., January 18, 2006; 26(3): 775 - 784.
[Abstract] [Full Text] [PDF]

S. Bauer and P. H. Patterson
The cell cycle-apoptosis connection revisited in the adult brain
J. Cell Biol., November 21, 2005; 171(4): 641 - 650.
[Abstract] [Full Text] [PDF]

S. Cicero and K. Herrup
Cyclin-Dependent Kinase 5 Is Essential for Neuronal Cell Cycle Arrest and Differentiation
J. Neurosci., October 19, 2005; 25(42): 9658 - 9668.
[Abstract] [Full Text] [PDF]

A. Mechelli, K. J. Friston, R. S. Frackowiak, and C. J. Price
Structural Covariance in the Human Cortex
J. Neurosci., September 7, 2005; 25(36): 8303 - 8310.
[Abstract] [Full Text] [PDF]

R. Narasimhaiah, A. Tuchman, S. L. Lin, and J. R. Naegele
Oxidative Damage and Defective DNA Repair is Linked to Apoptosis of Migrating Neurons and Progenitors During Cerebral Cortex Development in Ku70-Deficient Mice
Cereb Cortex, June 1, 2005; 15(6): 696 - 707.
[Abstract] [Full Text] [PDF]

M. Hamdane, A. Bretteville, A.-V. Sambo, K. Schindowski, S. Begard, A. Delacourte, P. Bertrand, and L. Buee
p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death
J. Cell Sci., March 15, 2005; 118(6): 1291 - 1298.
[Abstract] [Full Text] [PDF]

Y. Yang and K. Herrup
Loss of Neuronal Cell Cycle Control in Ataxia-Telangiectasia: A Unified Disease Mechanism
J. Neurosci., March 9, 2005; 25(10): 2522 - 2529.
[Abstract] [Full Text] [PDF]

K. Herrup, R. Neve, S. L. Ackerman, and A. Copani
Divide and Die: Cell Cycle Events as Triggers of Nerve Cell Death
J. Neurosci., October 20, 2004; 24(42): 9232 - 9239.
[Full Text] [PDF]

S. Marino, D. Hoogervoorst, S. Brandner, and A. Berns
Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence
Development, August 1, 2003; 130(15): 3359 - 3368.
[Abstract] [Full Text] [PDF]

Y. Yang, E. J. Mufson, and K. Herrup
Neuronal Cell Death Is Preceded by Cell Cycle Events at All Stages of Alzheimer's Disease
J. Neurosci., April 1, 2003; 23(7): 2557 - 2563.
[Abstract] [Full Text] [PDF]

L. M. Schang, A. Bantly, and P. A. Schaffer
Explant-Induced Reactivation of Herpes Simplex Virus Occurs in Neurons Expressing Nuclear cdk2 and cdk4
J. Virol., June 27, 2002; 76(15): 7724 - 7735.
[Abstract] [Full Text] [PDF]

A. Copani, D. Melchiorri, A. Caricasole, F. Martini, P. Sale, R. Carnevale, R. Gradini, M. A. Sortino, L. Lenti, R. De Maria, et al.
beta -Amyloid-Induced Synthesis of the Ganglioside Gd3 Is a Requisite for Cell Cycle Reactivation and Apoptosis in Neurons
J. Neurosci., May 15, 2002; 22(10): 3963 - 3968.
[Abstract] [Full Text] [PDF]

M. Mirjany, L. Ho, and G. M. Pasinetti
Role of Cyclooxygenase-2 in Neuronal Cell Cycle Activity and Glutamate-Mediated Excitotoxicity
J. Pharmacol. Exp. Ther., May 1, 2002; 301(2): 494 - 500.
[Abstract] [Full Text] [PDF]

H. Ino and T. Chiba
Cyclin-Dependent Kinase 4 and Cyclin D1 Are Required for Excitotoxin-Induced Neuronal Cell Death In Vivo
J. Neurosci., August 15, 2001; 21(16): 6086 - 6094.
[Abstract] [Full Text] [PDF]

J. Katchanov, C. Harms, K. Gertz, L. Hauck, C. Waeber, L. Hirt, J. Priller, R. von Harsdorf, W. Bruck, H. Hortnagl, et al.
Mild Cerebral Ischemia Induces Loss of Cyclin-Dependent Kinase Inhibitors and Activation of Cell Cycle Machinery before Delayed Neuronal Cell Death
J. Neurosci., July 15, 2001; 21(14): 5045 - 5053.
[Abstract] [Full Text] [PDF]

Y. Yang, D. S. Geldmacher, and K. Herrup
DNA Replication Precedes Neuronal Cell Death in Alzheimer's Disease
J. Neurosci., April 15, 2001; 21(8): 2661 - 2668.
[Abstract] [Full Text] [PDF]

M. T. Winkler, L. S. Schang, A. Doster, T. Holt, and C. Jones
Analysis of cyclins in trigeminal ganglia of calves infected with bovine herpesvirus-1
J. Gen. Virol., December 1, 2000; 81(12): 2993 - 2998.
[Abstract] [Full Text]

D. S. Smith, G. Leone, J. DeGregori, M. N. Ahmed, M. B. Qumsiyeh, and J. R. Nevins
Induction of DNA Replication in Adult Rat Neurons by Deregulation of the Retinoblastoma/E2F G1 Cell Cycle Pathway
Cell Growth Differ., December 1, 2000; 11(12): 625 - 633.
[Abstract] [Full Text]

Y. Chen, D. L. McPhie, J. Hirschberg, and R. L. Neve
The Amyloid Precursor Protein-binding Protein APP-BP1 Drives the Cell Cycle through the S-M Checkpoint and Causes Apoptosis in Neurons
J. Biol. Chem., March 17, 2000; 275(12): 8929 - 8935.
[Abstract] [Full Text] [PDF]

M. R. Roberts, K. Bittman, W.-W. Li, R. French, B. Mitchell, J. J. LoTurco, and S. R. D'Mello
The Flathead Mutation Causes CNS-Specific Developmental Abnormalities and Apoptosis
J. Neurosci., March 15, 2000; 20(6): 2295 - 2306.
[Abstract] [Full Text] [PDF]

F. Selimi, M. Doughty, N. Delhaye-Bouchaud, and J. Mariani
Target-Related and Intrinsic Neuronal Death in Lurcher Mutant Mice Are Both Mediated by Caspase-3 Activation
J. Neurosci., February 1, 2000; 20(3): 992 - 1000.
[Abstract] [Full Text] [PDF]

J. Frade
Unscheduled re-entry into the cell cycle induced by NGF precedes cell death in nascent retinal neurones
J. Cell Sci., January 4, 2000; 113(7): 1139 - 1148.
[Abstract] [PDF]

X. Zhu, A. K. Raina, and M. A. Smith
Cell Cycle Events in Neurons : Proliferation or Death?
Am. J. Pathol., August 1, 1999; 155(2): 327 - 329.
[Full Text] [PDF]

A. Migheli, R. Piva, S. Casolino, C. Atzori, S. R. Dlouhy, and B. Ghetti
A Cell Cycle Alteration Precedes Apoptosis of Granule Cell Precursors in the weaver Mouse Cerebellum
Am. J. Pathol., August 1, 1999; 155(2): 365 - 373.
[Abstract] [Full Text] [PDF]

K.-H. Herzog, S.-C. Chen, and J. I. Morgan
c-jun Is Dispensable for Developmental Cell Death and Axogenesis in the Retina
J. Neurosci., June 1, 1999; 19(11): 4349 - 4359.
[Abstract] [Full Text] [PDF]

V. Bruno, G. Battaglia, G. Casabona, A. Copani, F. Caciagli, and F. Nicoletti
Neuroprotection by Glial Metabotropic Glutamate Receptors Is Mediated by Transforming Growth Factor-beta
J. Neurosci., December 1, 1998; 18(23): 9594 - 9600.
[Abstract] [Full Text] [PDF]

M. P. Lambert, A. K. Barlow, B. A. Chromy, C. Edwards, R. Freed, M. Liosatos, T. E. Morgan, I. Rozovsky, B. Trommer, K. L. Viola, et al.
Diffusible, nonfibrillar ligands derived from Abeta 1-42 are potent central nervous system neurotoxins
PNAS, May 26, 1998; 95(11): 6448 - 6453.
[Abstract] [Full Text] [PDF]

J. Busser, D. S. Geldmacher, and K. Herrup
Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer's Disease Brain
J. Neurosci., April 15, 1998; 18(8): 2801 - 2807.
[Abstract] [Full Text] [PDF]

D. Thomaidou, M. C. Mione, J. F.�R. Cavanagh, and J. G. Parnavelas
Apoptosis and Its Relation to the Cell Cycle in the Developing Cerebral Cortex
J. Neurosci., February 1, 1997; 17(3): 1075 - 1085.
[Abstract] [Full Text] [PDF]

Nikitin AYu and W H Lee
Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice.
Genes & Dev., August 1, 1996; 10(15): 1870 - 1879.
[Abstract] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Herrup, K.

Articles by Busser, J. C.

Search for Related Content

PubMed

PubMed Citation

Articles by Herrup, K.

Articles by Busser, J. C.

Social Bookmarking

What's this?

				S. A. Rimkus, R. J. Katzenberger, A. T. Trinh, G. E. Dodson, R. S. Tibbetts, and D. A. Wassarman Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia Genes & Dev., May 1, 2008; 22(9): 1205 - 1220. [Abstract] [Full Text] [PDF]

				L. Wang, R. Wang, and K. Herrup E2F1 Works as a Cell Cycle Suppressor in Mature Neurons J. Neurosci., November 14, 2007; 27(46): 12555 - 12564. [Abstract] [Full Text] [PDF]

				L. Ferraiuolo, P. R. Heath, H. Holden, P. Kasher, J. Kirby, and P. J. Shaw Microarray Analysis of the Cellular Pathways Involved in the Adaptation to and Progression of Motor Neuron Injury in the SOD1 G93A Mouse Model of Familial ALS J. Neurosci., August 22, 2007; 27(34): 9201 - 9219. [Abstract] [Full Text] [PDF]

				Q. Liu, J. Zhang, H. Zhu, C. Qin, Q. Chen, and B. Zhao Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model FASEB J, January 1, 2007; 21(1): 61 - 73. [Abstract] [Full Text] [PDF]

				Y. Yang, N. H. Varvel, B. T. Lamb, and K. Herrup Ectopic Cell Cycle Events Link Human Alzheimer's Disease and Amyloid Precursor Protein Transgenic Mouse Models J. Neurosci., January 18, 2006; 26(3): 775 - 784. [Abstract] [Full Text] [PDF]

				S. Bauer and P. H. Patterson The cell cycle-apoptosis connection revisited in the adult brain J. Cell Biol., November 21, 2005; 171(4): 641 - 650. [Abstract] [Full Text] [PDF]

				S. Cicero and K. Herrup Cyclin-Dependent Kinase 5 Is Essential for Neuronal Cell Cycle Arrest and Differentiation J. Neurosci., October 19, 2005; 25(42): 9658 - 9668. [Abstract] [Full Text] [PDF]

				A. Mechelli, K. J. Friston, R. S. Frackowiak, and C. J. Price Structural Covariance in the Human Cortex J. Neurosci., September 7, 2005; 25(36): 8303 - 8310. [Abstract] [Full Text] [PDF]

				R. Narasimhaiah, A. Tuchman, S. L. Lin, and J. R. Naegele Oxidative Damage and Defective DNA Repair is Linked to Apoptosis of Migrating Neurons and Progenitors During Cerebral Cortex Development in Ku70-Deficient Mice Cereb Cortex, June 1, 2005; 15(6): 696 - 707. [Abstract] [Full Text] [PDF]

				M. Hamdane, A. Bretteville, A.-V. Sambo, K. Schindowski, S. Begard, A. Delacourte, P. Bertrand, and L. Buee p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death J. Cell Sci., March 15, 2005; 118(6): 1291 - 1298. [Abstract] [Full Text] [PDF]

				Y. Yang and K. Herrup Loss of Neuronal Cell Cycle Control in Ataxia-Telangiectasia: A Unified Disease Mechanism J. Neurosci., March 9, 2005; 25(10): 2522 - 2529. [Abstract] [Full Text] [PDF]

				K. Herrup, R. Neve, S. L. Ackerman, and A. Copani Divide and Die: Cell Cycle Events as Triggers of Nerve Cell Death J. Neurosci., October 20, 2004; 24(42): 9232 - 9239. [Full Text] [PDF]

				S. Marino, D. Hoogervoorst, S. Brandner, and A. Berns Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence Development, August 1, 2003; 130(15): 3359 - 3368. [Abstract] [Full Text] [PDF]

				Y. Yang, E. J. Mufson, and K. Herrup Neuronal Cell Death Is Preceded by Cell Cycle Events at All Stages of Alzheimer's Disease J. Neurosci., April 1, 2003; 23(7): 2557 - 2563. [Abstract] [Full Text] [PDF]

				L. M. Schang, A. Bantly, and P. A. Schaffer Explant-Induced Reactivation of Herpes Simplex Virus Occurs in Neurons Expressing Nuclear cdk2 and cdk4 J. Virol., June 27, 2002; 76(15): 7724 - 7735. [Abstract] [Full Text] [PDF]

				A. Copani, D. Melchiorri, A. Caricasole, F. Martini, P. Sale, R. Carnevale, R. Gradini, M. A. Sortino, L. Lenti, R. De Maria, et al. beta -Amyloid-Induced Synthesis of the Ganglioside Gd3 Is a Requisite for Cell Cycle Reactivation and Apoptosis in Neurons J. Neurosci., May 15, 2002; 22(10): 3963 - 3968. [Abstract] [Full Text] [PDF]

				M. Mirjany, L. Ho, and G. M. Pasinetti Role of Cyclooxygenase-2 in Neuronal Cell Cycle Activity and Glutamate-Mediated Excitotoxicity J. Pharmacol. Exp. Ther., May 1, 2002; 301(2): 494 - 500. [Abstract] [Full Text] [PDF]

				H. Ino and T. Chiba Cyclin-Dependent Kinase 4 and Cyclin D1 Are Required for Excitotoxin-Induced Neuronal Cell Death In Vivo J. Neurosci., August 15, 2001; 21(16): 6086 - 6094. [Abstract] [Full Text] [PDF]

				J. Katchanov, C. Harms, K. Gertz, L. Hauck, C. Waeber, L. Hirt, J. Priller, R. von Harsdorf, W. Bruck, H. Hortnagl, et al. Mild Cerebral Ischemia Induces Loss of Cyclin-Dependent Kinase Inhibitors and Activation of Cell Cycle Machinery before Delayed Neuronal Cell Death J. Neurosci., July 15, 2001; 21(14): 5045 - 5053. [Abstract] [Full Text] [PDF]

				Y. Yang, D. S. Geldmacher, and K. Herrup DNA Replication Precedes Neuronal Cell Death in Alzheimer's Disease J. Neurosci., April 15, 2001; 21(8): 2661 - 2668. [Abstract] [Full Text] [PDF]

				M. T. Winkler, L. S. Schang, A. Doster, T. Holt, and C. Jones Analysis of cyclins in trigeminal ganglia of calves infected with bovine herpesvirus-1 J. Gen. Virol., December 1, 2000; 81(12): 2993 - 2998. [Abstract] [Full Text]

				D. S. Smith, G. Leone, J. DeGregori, M. N. Ahmed, M. B. Qumsiyeh, and J. R. Nevins Induction of DNA Replication in Adult Rat Neurons by Deregulation of the Retinoblastoma/E2F G1 Cell Cycle Pathway Cell Growth Differ., December 1, 2000; 11(12): 625 - 633. [Abstract] [Full Text]

				Y. Chen, D. L. McPhie, J. Hirschberg, and R. L. Neve The Amyloid Precursor Protein-binding Protein APP-BP1 Drives the Cell Cycle through the S-M Checkpoint and Causes Apoptosis in Neurons J. Biol. Chem., March 17, 2000; 275(12): 8929 - 8935. [Abstract] [Full Text] [PDF]

				M. R. Roberts, K. Bittman, W.-W. Li, R. French, B. Mitchell, J. J. LoTurco, and S. R. D'Mello The Flathead Mutation Causes CNS-Specific Developmental Abnormalities and Apoptosis J. Neurosci., March 15, 2000; 20(6): 2295 - 2306. [Abstract] [Full Text] [PDF]

				F. Selimi, M. Doughty, N. Delhaye-Bouchaud, and J. Mariani Target-Related and Intrinsic Neuronal Death in Lurcher Mutant Mice Are Both Mediated by Caspase-3 Activation J. Neurosci., February 1, 2000; 20(3): 992 - 1000. [Abstract] [Full Text] [PDF]

				J. Frade Unscheduled re-entry into the cell cycle induced by NGF precedes cell death in nascent retinal neurones J. Cell Sci., January 4, 2000; 113(7): 1139 - 1148. [Abstract] [PDF]

				X. Zhu, A. K. Raina, and M. A. Smith Cell Cycle Events in Neurons : Proliferation or Death? Am. J. Pathol., August 1, 1999; 155(2): 327 - 329. [Full Text] [PDF]

				A. Migheli, R. Piva, S. Casolino, C. Atzori, S. R. Dlouhy, and B. Ghetti A Cell Cycle Alteration Precedes Apoptosis of Granule Cell Precursors in the weaver Mouse Cerebellum Am. J. Pathol., August 1, 1999; 155(2): 365 - 373. [Abstract] [Full Text] [PDF]

				K.-H. Herzog, S.-C. Chen, and J. I. Morgan c-jun Is Dispensable for Developmental Cell Death and Axogenesis in the Retina J. Neurosci., June 1, 1999; 19(11): 4349 - 4359. [Abstract] [Full Text] [PDF]

				V. Bruno, G. Battaglia, G. Casabona, A. Copani, F. Caciagli, and F. Nicoletti Neuroprotection by Glial Metabotropic Glutamate Receptors Is Mediated by Transforming Growth Factor-beta J. Neurosci., December 1, 1998; 18(23): 9594 - 9600. [Abstract] [Full Text] [PDF]